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2026 data Public-data reference. official source

Gastroparesis

Open-data reference.

45 US clinical trials · 24 currently recruiting

Active & Recent Trials

RECRUITING 5,000 participants

Indiana University Gastrointestinal Motility Diagnosis Registry

Indiana University

NCT04506593

RECRUITING 3,000 participants

Gastroparesis Outcome Longitudinal Database Enrolled Numerically

University of Louisville

NCT03876288

RECRUITING 685 participants

BSGM to Evaluate Patients With GI Symptoms

Children's Hospital of Philadelphia

NCT05880199

RECRUITING 600 participants

Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders

AdventHealth

NCT05905016

RECRUITING 400 participants

IVIG for Drug and Device Refractory Gastrointestinal Auto-Immune Neuropathy

University of Louisville

NCT04208828

RECRUITING Phase 2 320 participants

Different Doses of Naronapride Vs. Placebo in Gastroparesis

Dr. Falk Pharma

NCT05621811

RECRUITING 300 participants

GI Neuromuscular Pathology Prospective Registry

Indiana University

NCT02165059

RECRUITING 250 participants

Gastroparesis Registry 4

Johns Hopkins Bloomberg School of Public Health

NCT05846802

RECRUITING 216 participants

GpCRC Pediatric Gastroparesis Registry 2

Johns Hopkins Bloomberg School of Public Health

NCT05981300

RECRUITING Phase 3 200 participants

Domperidone in Treating Patients With Gastrointestinal Disorders

M.D. Anderson Cancer Center

NCT01696734

RECRUITING 150 participants

Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms

Johns Hopkins Bloomberg School of Public Health

NCT04661215

RECRUITING 75 participants

Gastric Per-Oral Endoscopic Myotomy (G-POEM) for the Treatment of Gastroparesis

Indiana University

NCT04434781

RECRUITING NA 65 participants

Vagal Nerve Stimulation for Functional Dyspepsia and Gastroparesis

Massachusetts General Hospital

NCT03603730

RECRUITING NA 50 participants

Study of Enhanced Programming Stimulation with the Enterra® Therapy System

Enterra Medical

NCT06560307

RECRUITING NA 50 participants

Study of Enterra Programming with Nocturnal Cycling in Gastroparetics

Enterra Medical

NCT05980455

RECRUITING NA 40 participants

Impact of Per Oral Pyloromyotomy (POP) on Glycemic Control in Diabetes

Matthew Allemang

NCT04696159

RECRUITING NA 36 participants

Transpyloric Stenting As a Predictor for G-POEM for Refractory Gastroparesis

Northwestern University

NCT04287647

RECRUITING 30 participants

Study of Gastric Motility in Eosinophilic Gastritis

Children's Hospital Medical Center, Cincinnati

NCT05229432

RECRUITING NA 29 participants

Central and Peripheral Effects of Cognitive Behavioral Therapy on Brain-Gut Axis Signaling in Gastroparetic Patients

Massachusetts General Hospital

NCT03531450

RECRUITING NA 20 participants

The Use of Body Surface Gastric Mapping in Assessing the Clinical Success of G-POEM

Indiana University

NCT06493032

RECRUITING NA 20 participants

Compassionate Use of Domperidone for Refractory Gastroparesis

Children's Mercy Hospital Kansas City

NCT04699591

RECRUITING Phase 1 16 participants

TENS in Scleroderma

University of Michigan

NCT06646913

RECRUITING NA 10 participants

Brain-Gut Yoga for Functional Dyspepsia and Gastroparesis (FD-GP)

Wake Forest University Health Sciences

NCT06732453

RECRUITING Early Phase 1 10 participants

Growth Hormone for the Treatment of Gastroparesis

Mayo Clinic

NCT06803589

ACTIVE NOT RECRUITING 300 participants

Cardiac Vagal Effects of GES in Patients With Gastroparesis and Vagal Nerve Action Potentials in Vagus Nerve

Indiana University

NCT02159586

ACTIVE NOT RECRUITING 250 participants

Prospective Evaluation of the Efficacy and Safety of Submucosal Endoscopy

University of Colorado, Denver

NCT03626350

ACTIVE NOT RECRUITING NA 131 participants

ABVN Phase 2-Studying the Effect of Stimulation on the Auricular Branch of the Vagal Nerve

Indiana University

NCT06491758

ACTIVE NOT RECRUITING NA 100 participants

Endoscopic Myotomy of the Pylorus To Improve Emptying and Symptoms Trial

Matthew Allemang

NCT05039424

ACTIVE NOT RECRUITING 40 participants

Vagus Nerve Response in Gastroparesis Patients

Indiana University

NCT04207996

ACTIVE NOT RECRUITING NA 31 participants

Magnetic Resonance Imaging of the Brain and Stomach in Healthy Volunteers and Gastroparesis

Indiana University School of Medicine

NCT04282317

ACTIVE NOT RECRUITING NA 17 participants

Magnetically Controlled Capsule Endoscopy Feasibility Study in Gastric Motility

University of California, Los Angeles

NCT05004012

COMPLETED NA 182 participants

Establishing a Pediatric Reference Range for the 13C-Spirulina Gastric Emptying Breath Test (GEBT)

Cairn Diagnostics

NCT06004596

COMPLETED Phase 2 152 participants

Study to Assess the Efficacy of VLY-686 in Relieving Symptoms of Gastroparesis

Vanda Pharmaceuticals

NCT02970968

COMPLETED 148 participants

A Comparison of SmartPill Capsule With Scintigraphy for Determining Gastric Residence Time

The SmartPill Corporation

NCT00128284

COMPLETED 108 participants

Using Point-of-Care-Ultrasound (POCUS) to Assess Gastric Contents Among Fasting Pre-operative Patients Taking GLP-1 Agonists.

University of North Carolina, Chapel Hill

NCT06038734

COMPLETED Phase 2 79 participants

Dose Response of 28 Days of Dosing of GSK962040 in Type I and II Diabetic Male and Female Subjects With Gastroparesis

GlaxoSmithKline

NCT01262898

COMPLETED Phase 4 69 participants

Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy

The Cleveland Clinic

NCT06533527

COMPLETED Phase 1 24 participants

Modulation of Heme Oxygenase 1 by Nizatidine and Lisinopril in Healthy Subjects

Adil Bharucha

NCT02232308

COMPLETED NA 23 participants

Transcutaneous Electroacupuncture for Gastric Complications of Scleroderma

Johns Hopkins University

NCT03294616

COMPLETED Phase 1 20 participants

Study to Assess Pharmacodynamics of RM-131 in Patients With Diabetic Gastroparesis

Motus Therapeutics

NCT01394055

COMPLETED Phase 3 14 participants

Sancuso® for Gastroparesis: An Open Label Study.

Temple University

NCT01989221

COMPLETED Early Phase 1 14 participants

Pioglitazone for Idiopathic Gastroparesis

Johns Hopkins University

NCT04300127

COMPLETED NA 10 participants

Validation of Plant-Based Vegan Meal for Gastric Emptying Testing in 10 Healthy Subjects

Mayo Clinic

NCT06991036

COMPLETED Phase 1 8 participants

Safety and Pharmacokinetic Study of C13-URA in Healthy Volunteers

Otsuka Pharmaceutical Co.

NCT01074710

COMPLETED NA 3 participants

Endoscopic Full Thickness Biopsy, Gastric Wall.

Mayo Clinic

NCT01650714

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 3
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gastroparesis Trial Landscape

ClinicalTrials.gov lists 45 US studies indexed under Gastroparesis, and 24 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Gastroparesis shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Gastroparesis is led by Indiana University with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 45 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gastroparesis?

PlainTrial tracks 45 US clinical trials for Gastroparesis, of which 24 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gastroparesis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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