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NCT02546219 · ClinicalTrials.gov registry record
a4b7 Integrin in Eosinophilic Esophagitis
A clinical trial of Eosinophilic Esophagitis, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- 16
- Enrollment target
- 1
- Study location
NCT02546219: Completed study of Eosinophilic Esophagitis, sponsored by Massachusetts General Hospital.
NCT02546219 is a study of Eosinophilic Esophagitis that has completed, run by Massachusetts General Hospital. The registered enrollment target is 16 participants, below the 864-participant average among 44 other Eosinophilic Esophagitis trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02546219, a study of Eosinophilic Esophagitis, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- 16 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall objective of this preclinical study is to further the investigators mechanistic understanding of the role that the α4β7 and mucosal addressin cell adhesion molecule (MAdCAM-1) pathway plays in mediating eosinophil recruitment in EoE. To accomplish this, the investigators aim to (1) determine the baseline and dynamic patterns of α4β7 integrin expression on circulating and tissue eosinophils in EoE and in the setting of non-EoE esophageal eosinophilia (e.g., reflux esophagitis) and (2) determine the complete profile of eosinophil integrin molecules that may play a role in active EoE.
Primary Outcome
Eosinophil expression levels of a4b7 integrin will be assessed on peripheral and esophageal eosinophils during active EoE and after treatment-induced remission.
Conditions Studied
Interventions
- OTHER Eosinophil isolation and characterization.
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2016-03 |
| Est. Completion | 2018-12-31 |
What the finished NCT02546219 record still lists
NCT02546219 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 864-participant average among 44 other Eosinophilic Esophagitis trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Eosinophilic Esophagitis appearing as the primary indexed condition, and to 1 intervention - of which Eosinophil isolation and characterization. is the first listed.
NCT02546219 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT02546219 about?
NCT02546219 is a clinical study titled "a4b7 Integrin in Eosinophilic Esophagitis". The overall objective of this preclinical study is to further the investigators mechanistic understanding of the role that the α4β7 and mucosal addressin cell adhesion molecule (MAdCAM-1) pathway plays in mediating eosinophil recruitment in EoE. To accomplish this, the investigators aim to (1) deter...
What is the current status of trial NCT02546219?
This trial is currently completed. The enrollment target is 16 participants. The study started on 2016-03. Estimated completion is 2018-12-31.
What conditions does trial NCT02546219 study?
This clinical trial studies the following conditions: Eosinophilic Esophagitis.
What interventions are being tested in trial NCT02546219?
The interventions under investigation include: Eosinophil isolation and characterization. (OTHER).
Who is sponsoring clinical trial NCT02546219?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02546219 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Eosinophilic Esophagitis
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Where NCT02546219's enrollment target sits among peer trials
16 40th of 44 higher than 4 of 44 other Eosinophilic Esophagitis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Eosinophilic Esophagitis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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