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RECRUITING Phase 2

A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

NCT06851559 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of this study is to assess the efficacy of vonoprazan 20 mg once daily (QD) compared to placebo QD in the number of participants with a peak eosinophilic histologic response \<15 eosinophils per high-power field (eos/hpf) after 12 weeks of therapy.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Vonoprazan

Study Locations (20)

Florida

  • Nature Coast Clinical Research — Inverness
  • Encore Borland-Groover Clinical Research — Jacksonville
  • International Center for Research — Tampa

California

  • GW Research, Inc — Chula Vista
  • Southern California Research Institute Medical Group — Los Angeles

Colorado

  • Rocky Mountain Gastroenterology — Lakewood
  • Western States Clinical Research, Inc. — Wheat Ridge

Idaho

  • Treasure Valley Medical Research — Boise
  • Grand Teton Research Group — Idaho Falls

Illinois

  • Northwestern Medicine Digestive Health Center — Chicago
  • GI Alliance - Gurnee — Gurnee

Louisiana

  • Combined Gastro, LLC — Lafayette
  • Tandem Clinical Research GI, LLC — Marrero

Arkansas

  • Preferred Research Partners, Inc — Little Rock

Connecticut

  • Connecticut Clinical Research Institute — Bristol

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2025-10-30
Est. Completion 2027-03
Phase Phase 2

Sponsor

Phathom Pharmaceuticals

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06851559

The ClinicalTrials.gov registry entry for NCT06851559 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Phathom Pharmaceuticals, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Eosinophilic Esophagitis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06851559 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Florida, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06851559 about?

NCT06851559 is a clinical study titled "A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks". The primary objective of this study is to assess the efficacy of vonoprazan 20 mg once daily (QD) compared to placebo QD in the number of participants with a peak eosinophilic histologic response \<15 eosinophils per high-power field (eos/hpf) after 12 weeks of therapy.

What is the current status of trial NCT06851559?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2025-10-30. Estimated completion is 2027-03.

What conditions does trial NCT06851559 study?

This clinical trial studies the following conditions: Eosinophilic Esophagitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06851559?

The interventions under investigation include: Placebo (DRUG), Vonoprazan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06851559?

This trial is sponsored by Phathom Pharmaceuticals, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06851559 being conducted?

This trial has 20 study locations across Arkansas, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial