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NCT03312686 · ClinicalTrials.gov registry record
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study
A clinical trial of Eosinophilic Esophagitis, sponsored by Indiana University.
- Recruiting
- Registry status
- 10
- Enrollment target
- 2
- Study locations
NCT03312686: Recruiting study of Eosinophilic Esophagitis, sponsored by Indiana University.
NCT03312686 is a study of Eosinophilic Esophagitis that is actively recruiting participants, run by Indiana University. The registered enrollment target is 10 participants, below the 864-participant average among 44 other Eosinophilic Esophagitis trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03312686, a study of Eosinophilic Esophagitis, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- 10 participants
- Enrollment target
- 2
- Study locations
Study Summary
This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esophagus using EndoFlip only measured distensibility of the distal esophagus, specifically the distal esophagus and esophagogastric junction. Eosinophilia in EoE has been demonstrated to affect both upper, middle and lower esophagus. The aim is to measure distensibility both proximal and distal, before and after treatment.
Primary Outcome
1\. Measure the changes in esophageal distensibility before and after treatment with PPI in patients with esophageal eosinophilia
Conditions Studied
Interventions
- DIAGNOSTIC_TEST endoflip
Study Locations (2)
Indiana
- Indiana University Health University Hospital - Indianapolis
- Indiana University - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2016-11 |
| Est. Completion | 2026-12-31 |
What NCT03312686 shows while recruiting
NCT03312686 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 864-participant average among 44 other Eosinophilic Esophagitis trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Eosinophilic Esophagitis appearing as the primary indexed condition, and to 1 intervention - of which endoflip is the first listed.
NCT03312686 reports a single indexed study location in Indiana.
Frequently Asked Questions
What is clinical trial NCT03312686 about?
NCT03312686 is a clinical study titled "Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study". This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esophagus using EndoFlip only measured distensibility of the distal esophagus, specifically the distal es...
What is the current status of trial NCT03312686?
This trial is currently recruiting. The enrollment target is 10 participants. The study started on 2016-11. Estimated completion is 2026-12-31.
What conditions does trial NCT03312686 study?
This clinical trial studies the following conditions: Eosinophilic Esophagitis.
What interventions are being tested in trial NCT03312686?
The interventions under investigation include: endoflip (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT03312686?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03312686 being conducted?
This trial has 2 study locations across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Eosinophilic Esophagitis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03312686's enrollment target sits among peer trials
10 43rd of 44 higher than 2 of 44 other Eosinophilic Esophagitis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Eosinophilic Esophagitis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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