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NCT06705387 · ClinicalTrials.gov registry record · Phase 2
Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoE
A Phase 2 study of Eosinophilic Esophagitis, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 72
- Enrollment target
- 1
- Study location
NCT06705387: Recruiting Phase 2 study of Eosinophilic Esophagitis, sponsored by University of Colorado, Denver.
NCT06705387 is a Phase 2 study of Eosinophilic Esophagitis that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 72 participants, below the 862-participant average among 44 other Eosinophilic Esophagitis trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06705387, a Phase 2 study of Eosinophilic Esophagitis, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 72 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to \[primary purpose: e.g., learn if intervention or health behavior can treat, prevent, diagnose etc.\] in \[describe participant population/primary condition; could include any of the following: sex/gender, age groups, healthy volunteers\]. The main question\[s\] it aims to answer \[is/are\]: Does dupilumab or swallowed topical fluticasone improve the diameter of the esophagus more? Does dupilumab or swallowed topical fluticasone reduce inflammation in the esophagus more? Are comparative effective clinical trials feasible in this patient population? Researchers will compare dupilumab 300 mg weekly compared to swallowed fluticasone to see if there is a difference in treatment response. Participants will be asked to: * Be randomized to either dupilumab sq weekly or swallowed topical fluticasone twice daily. * Participate in 8 study visits over 52 weeks * Complete questionnaires * Have an endoscopy with biopsies and EndoFLIP measurements. * Swallow an Esophageal String Test
Primary Outcome
Change in distensibility (mm) from baseline to end of treatment (continuous). This is measured by EndoFLIP.
Conditions Studied
Interventions
- BIOLOGICAL Dupilumab
- DRUG Fluticasone
Study Locations (1)
Colorado
- Children's Hospital Colorado/University of Colorado School of Medicine - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2024-12-23 |
| Est. Completion | 2027-03 |
| Phase | Phase 2 |
What NCT06705387 shows while recruiting
NCT06705387 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 72 participants, a relatively small participant target, below the 862-participant average among 44 other Eosinophilic Esophagitis trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Eosinophilic Esophagitis appearing as the primary indexed condition, and to 2 interventions - of which Dupilumab is the first listed.
NCT06705387 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT06705387 about?
NCT06705387 is a clinical study titled "Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoE". The goal of this clinical trial is to \[primary purpose: e.g., learn if intervention or health behavior can treat, prevent, diagnose etc.\] in \[describe participant population/primary condition; could include any of the following: sex/gender, age groups, healthy volunteers\]. The main question\[s\]...
What is the current status of trial NCT06705387?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 72 participants. The study started on 2024-12-23. Estimated completion is 2027-03.
What conditions does trial NCT06705387 study?
This clinical trial studies the following conditions: Eosinophilic Esophagitis.
What interventions are being tested in trial NCT06705387?
The interventions under investigation include: Dupilumab (BIOLOGICAL), Fluticasone (DRUG).
Who is sponsoring clinical trial NCT06705387?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06705387 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Eosinophilic Esophagitis
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Where NCT06705387's enrollment target sits among peer trials
72 24th of 44 higher than 21 of 44 other Eosinophilic Esophagitis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Eosinophilic Esophagitis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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