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NCT03822325 · ClinicalTrials.gov registry record
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
A clinical trial of Eosinophilic Esophagitis, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- Active
- Registry status
- 88
- Enrollment target
- 2
- Study locations
NCT03822325: Active study of Eosinophilic Esophagitis, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
NCT03822325 is a study of Eosinophilic Esophagitis that is active but no longer recruiting, run by Ann & Robert H Lurie Children's Hospital of Chicago. The registered enrollment target is 88 participants, below the 862-participant average among 44 other Eosinophilic Esophagitis trials with a reported enrollment target (90% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03822325, a study of Eosinophilic Esophagitis, is active but no longer recruiting, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- ACTIVE NOT RECRUITING
- Registry status
- 88 participants
- Enrollment target
- 2
- Study locations
Study Summary
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine the presence of active Eosinophilic Esophagitis. For these purposes, the investigators will correlate esophageal inflammatory mediators measured in blood and urine with histological findings identified on esophageal mucosal biopsies. Additionally, biopsies associated mediators will be assessed relative to clinical phenotype and outcome.
Primary Outcome
Frozen biopsies and archived slides from EoE patients and controls will be used in testing molecules released by or expressed on the cell surface of inflammatory cells. The molecules will be assessed using RNA sequencing, ELISA, and immunohistochemistry. This information will be correlated with eosinophil counts along with endoscopy findings, treatment outcomes and clinical measures of the disease such as symptoms, atopic co-morbidities, and demographics.
Conditions Studied
Study Locations (2)
Illinois
- Ann & Robert H Lurie Children's Hospital of Chicago - Chicago
- University of Illinois at Chicago (UIC) - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 88 participants |
| Start Date | 2011-02 |
| Est. Completion | 2025-11 |
What the registry record for NCT03822325 still lists
NCT03822325 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 88 participants, a relatively small participant target, below the 862-participant average among 44 other Eosinophilic Esophagitis trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Eosinophilic Esophagitis appearing as the primary indexed condition, and to 0 interventions.
NCT03822325 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT03822325 about?
NCT03822325 is a clinical study titled "Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis". The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine the presence of active Eosinophilic Esophagitis. For these purposes, th...
What is the current status of trial NCT03822325?
This trial is currently active not recruiting. The enrollment target is 88 participants. The study started on 2011-02. Estimated completion is 2025-11.
What conditions does trial NCT03822325 study?
This clinical trial studies the following conditions: Eosinophilic Esophagitis.
Who is sponsoring clinical trial NCT03822325?
This trial is sponsored by Ann & Robert H Lurie Children's Hospital of Chicago, which has 159 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03822325 being conducted?
This trial has 2 study locations across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Eosinophilic Esophagitis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03822325's enrollment target sits among peer trials
88 22nd of 44 higher than 23 of 44 other Eosinophilic Esophagitis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Eosinophilic Esophagitis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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