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Diabetes Mellitus, Type 2 clinical trials
63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.
351 US clinical trials · 63 currently recruiting
Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.
The research picture
Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.
- 63
- recruiting participants now
- 18%
- of trials open to enrollment
- 100
- in Phase 3–4 (later-stage)
- 48
- top sponsor: Novo Nordisk A/S
Active & Recent Trials
351 total, page 1 of 8
Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)
Stanford University
NCT06251323
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
Boehringer Ingelheim
NCT07064473
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
Cleerly
NCT06112418
Blood Markers of Early Pancreas Cancer
University of Nebraska
NCT03568630
Improving Diabetes Care With Strategies For Addressing Health-Related Social Needs and Community Partnerships
Boston Medical Center
NCT07043426
Promoting Preconception Care and Diabetes Self-Management Among Reproductive-Aged Women With Diabetes
Northwestern University
NCT04976881
Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)
The University of Texas Health Science Center at San Antonio
NCT02969798
Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)
Ohio State University
NCT05472441
Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads
University of South Carolina
NCT05370014
Healthy Communities Through CHW Initiatives
The University of Texas Medical Branch, Galveston
NCT05965869
Safer Aging With Diabetes Monitoring
Kaiser Permanente
NCT06296485
DETERMINE: Detemir vs NPH
University of California, Los Angeles
NCT05124457
Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus
Medical College of Wisconsin
NCT05692388
Increasing CGM Use Among Patients With T2D
San Diego State University
NCT06638099
Sleep for Health Study on the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk
Kaiser Permanente
NCT06067139
Effect of Continuing Versus Holding Metformin During Hospitalizations.
University of Illinois at Chicago
NCT06296836
Family Model DSME in FBOs in the RMI
University of Arkansas
NCT05502016
Boosting Emotional Well-being and Happiness in Outpatients Living With Diabetes
Massachusetts General Hospital
NCT05420051
Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes
Endogenex
NCT06267391
Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery
University of Colorado, Denver
NCT07011147
Care Navigator Support for Younger Latinx Adults With Type 2 Diabetes
Kaiser Permanente
NCT05754008
Food as Medicine for HIV and Diabetes
University of North Carolina, Chapel Hill
NCT05026723
A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes
Eli Lilly and Company
NCT07215559
Transformative Research in Diabetic Nephropathy 2.0
University of Pennsylvania
NCT07444203
PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG
Aventusoft
NCT06567795
Food Insecurity Reduction & Strategy Team
Stanford University
NCT06329375
Drug Interaction Potential of Pro-Inflammatory Conditions
Indiana University
NCT07360938
Strategies to Improve Well-Being and Diabetes Management
Elizabeth Scharnetzki
NCT06348238
Diabetes Learning in Virtual Environments Just in Time for Community Reentry
Louise Reagan
NCT05286892
Diabetes Toolkit at Discharge
Northwestern University
NCT05663931
Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes
University of Kansas Medical Center
NCT06478186
HOPE Intervention for Fitness
University of California, Irvine
NCT07114822
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Stanford University
NCT05165706
Phenotyping Genetic Risk for Type 2 Diabetes
University of Pennsylvania
NCT04024631
MANAGe-DM: Novel Nurse Case Management to Improve Diabetes Outcomes in Formerly Incarcerated Black Men
Medical College of Wisconsin
NCT06031428
Post Prandial Individual Responses to Different Foods
Stanford University
NCT06989164
A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin
Eli Lilly and Company
NCT07215312
Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes
Seattle Children's Hospital
NCT06936670
Gemini Study: A Prospective, Multicenter Evaluation of Performance and Safety of the Eversense Gemini System With Flash Glucose Measurement Feature
Senseonics
NCT07386340
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
University of Michigan
NCT06574035
Use of CGM in Kidney Transplant Recipients
University of California, Davis
NCT04783441
OASIS: Peer Support for T2DM in Appalachia (Peer Participant)
University of Kentucky
NCT06336122
Promoting Intergenerational Health in Rural Kentuckians With Diabetes (PIHRK'D)
The University of Texas Medical Branch, Galveston
NCT06080425
Impact of a Diabetes Education Mobile Web Application on Patients With Uncontrolled Type 2 Diabetes
The Reading Hospital and Medical Center
NCT05893927
Multiple Dose Study of MK-2828 in Participants With Type 2 Diabetes (MK-2828-003)
Merck Sharp & Dohme
NCT07089784
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
Bettina Mittendorfer
NCT06571474
Time-Restricted Eating for Type II Diabetes: TRE-T2D
University of California, San Diego
NCT05365529
In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes
Cornell University
NCT06557317
A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)
Merck Sharp & Dohme
NCT07242469
Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes
Samita Garg
NCT06046833
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 42 |
| Phase 2 | 38 |
| Phase 3 | 74 |
| Phase 4 | 26 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 2 Trial Landscape
351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).
Phase mix: 100 late (III/IV) vs 80 early (I/II).
Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 2?
PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 2?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.