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Diabetes Mellitus, Type 2 clinical trials
63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.
351 US clinical trials · 63 currently recruiting
Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.
The research picture
Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.
- 63
- recruiting participants now
- 18%
- of trials open to enrollment
- 100
- in Phase 3–4 (later-stage)
- 48
- top sponsor: Novo Nordisk A/S
Active & Recent Trials
351 total, page 2 of 8
Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes
University of Washington
NCT05780905
Project Dulce for Arab Americans With Type 2 Diabetes
Scripps Whittier Diabetes Institute
NCT05580536
Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes
Pennington Biomedical Research Center
NCT05958368
Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population
San Diego State University
NCT05279729
Trial to Assess Continuous Glucose Monitoring in Asian Americans With Type 2 Diabetes
Joslin Diabetes Center
NCT05826678
Efficacy of Using Mobile Health Applications for Health
San Diego State University
NCT05589155
Pilot-Testing Real-Time Engagement for Learning to Effectively Control Type 2 Diabetes
University of Pittsburgh
NCT07270016
Exercise and Time of Day in Type 2 Diabetes
Rutgers, The State University of New Jersey
NCT05108987
Improvement of Hyperglycemia/Diabetes in Patients to Improve Safety
Northwestern University
NCT06096311
OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)
Brittany L Smalls
NCT06003634
Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)
Yale University
NCT05776563
The Acute T-Rex (Timing of Resistance Exercise) Study
University of Utah
NCT06366399
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
University of Nebraska
NCT06480786
Comparative Effectiveness of Empagliflozin in the US
Boehringer Ingelheim
NCT03363464
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
Weight Loss Clinical Decision Support
HealthPartners Institute
NCT05198765
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
Novo Nordisk A/S
NCT03811561
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
Eli Lilly and Company
NCT06260722
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans
Massachusetts General Hospital
NCT01762046
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both
Novo Nordisk A/S
NCT06534411
Kaiser Permanente Evaluating Nutritional Interventions in Food-Insecure High-Risk Adults Study
Kaiser Permanente
NCT06061861
A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight
Boehringer Ingelheim
NCT06066528
Integrating Abbott Point-of-Care Technologies and the Community Scientist Model to Support HbA1c Testing Per ADA
Sansum Diabetes Research Institute
NCT05000840
Empowering Veterans to Actively Communicate and Engage in Shared Decision Making in Medical Visits, A Randomized Controlled Trial
VA Office of Research and Development
NCT05169359
Biological Sample Repository for Gastrointestinal Disorders
Pichamol Jirapinyo, MD, MPH
NCT05874726
Addressing Basic Needs to Improve Diabetes Outcomes in Medicaid Beneficiaries
Washington University School of Medicine
NCT03940209
Decreasing Cardiovascular Risk for Patients With Diabetes
Michigan State University
NCT04874116
Glucose Monitoring Comparison in Primary Care
HealthPartners Institute
NCT05222815
Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology
Pennington Biomedical Research Center
NCT05523375
Using Early Time Restricted Feeding and Timed Light Therapy to Improve Glycemic Control in Adults With Type 2 Diabetes
University of Alabama at Birmingham
NCT04155619
Evaluating Telementoring for CHW-centered Diabetes Initiatives
The University of Texas Medical Branch, Galveston
NCT04835493
A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus
University of California, Los Angeles
NCT04897945
Food Delivery, Remote Monitoring, and Coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)
University of Alabama at Birmingham
NCT05288452
Continuous Glucose Monitoring Devices in Hospitalized Veterans With Diabetes
VA Office of Research and Development
NCT03508934
A Family Dyad-focused Diabetes Self-Management Intervention for African American Adults
Ohio State University
NCT05905575
Food As MedicinE for Diabetes
University of North Carolina, Chapel Hill
NCT04828785
The Dietary Guidelines 3 Diet Patterns Study (DG3D): Phase 2
University of South Carolina
NCT05254496
The HIV, Adipose Tissue Immunology, and Metabolism Study
Vanderbilt University Medical Center
NCT04451980
Lowering Food Insecurity and Improving Diabetes With Financial Incentives
State University of New York at Buffalo
NCT05352022
A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy
Novo Nordisk A/S
NCT06797869
Diabetes Discharge Transitional CGM Study (DDT-CGM)
Intermountain Health Care
NCT04729985
Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes
University of Alabama at Birmingham
NCT04542148
Precision Diets for Diabetes Prevention
Stanford University
NCT03919877
Mastering Diabetes Study
Ohio University
NCT04454957
Surgical or Medical Treatment
Children's Hospital Medical Center, Cincinnati
NCT04128995
Electronic Diabetes Tune-Up Group (eDTU) for African Americans
Indiana University
NCT06321029
Study of Subcutaneously Administered ENT-03 for the Treatment of Obesity and Diabetes
Metabolics Pharma
NCT05925920
Michigan Men's Diabetes Project 2
University of Michigan
NCT05370781
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans
University of Pittsburgh
NCT02710370
Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics
Washington University School of Medicine
NCT03348280
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 42 |
| Phase 2 | 38 |
| Phase 3 | 74 |
| Phase 4 | 26 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 2 Trial Landscape
351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).
Phase mix: 100 late (III/IV) vs 80 early (I/II).
Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 2?
PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 2?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.