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ClinicalTrials.gov 63 recruiting now official registry

Diabetes Mellitus, Type 2 clinical trials

63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.

351 US clinical trials · 63 currently recruiting

Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.

The research picture

Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.

63
recruiting participants now
18%
of trials open to enrollment
100
in Phase 3–4 (later-stage)
48
top sponsor: Novo Nordisk A/S
Phase 142Phase 238Phase 374Phase 426

Active & Recent Trials

351 total, page 2 of 8

RECRUITING Phase 4 50 participants

Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes

University of Washington

NCT05780905

RECRUITING NA 48 participants

Project Dulce for Arab Americans With Type 2 Diabetes

Scripps Whittier Diabetes Institute

NCT05580536

RECRUITING NA 48 participants

Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes

Pennington Biomedical Research Center

NCT05958368

RECRUITING NA 45 participants

Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population

San Diego State University

NCT05279729

RECRUITING NA 30 participants

Trial to Assess Continuous Glucose Monitoring in Asian Americans With Type 2 Diabetes

Joslin Diabetes Center

NCT05826678

RECRUITING NA 30 participants

Efficacy of Using Mobile Health Applications for Health

San Diego State University

NCT05589155

RECRUITING NA 30 participants

Pilot-Testing Real-Time Engagement for Learning to Effectively Control Type 2 Diabetes

University of Pittsburgh

NCT07270016

RECRUITING NA 30 participants

Exercise and Time of Day in Type 2 Diabetes

Rutgers, The State University of New Jersey

NCT05108987

RECRUITING 30 participants

Improvement of Hyperglycemia/Diabetes in Patients to Improve Safety

Northwestern University

NCT06096311

RECRUITING NA 25 participants

OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)

Brittany L Smalls

NCT06003634

RECRUITING NA 24 participants

Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)

Yale University

NCT05776563

RECRUITING NA 20 participants

The Acute T-Rex (Timing of Resistance Exercise) Study

University of Utah

NCT06366399

RECRUITING NA 15 participants

SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

University of Nebraska

NCT06480786

ACTIVE NOT RECRUITING 230,000 participants

Comparative Effectiveness of Empagliflozin in the US

Boehringer Ingelheim

NCT03363464

ACTIVE NOT RECRUITING NA 20,000 participants

Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)

Signos

NCT05874635

ACTIVE NOT RECRUITING NA 10,120 participants

Weight Loss Clinical Decision Support

HealthPartners Institute

NCT05198765

ACTIVE NOT RECRUITING Phase 3 1,500 participants

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

Novo Nordisk A/S

NCT03811561

ACTIVE NOT RECRUITING Phase 3 1,250 participants

Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)

Eli Lilly and Company

NCT06260722

ACTIVE NOT RECRUITING Phase 1 1,033 participants

Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans

Massachusetts General Hospital

NCT01762046

ACTIVE NOT RECRUITING Phase 3 1,023 participants

A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both

Novo Nordisk A/S

NCT06534411

ACTIVE NOT RECRUITING NA 1,007 participants

Kaiser Permanente Evaluating Nutritional Interventions in Food-Insecure High-Risk Adults Study

Kaiser Permanente

NCT06061861

ACTIVE NOT RECRUITING Phase 3 755 participants

A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight

Boehringer Ingelheim

NCT06066528

ACTIVE NOT RECRUITING 750 participants

Integrating Abbott Point-of-Care Technologies and the Community Scientist Model to Support HbA1c Testing Per ADA

Sansum Diabetes Research Institute

NCT05000840

ACTIVE NOT RECRUITING NA 512 participants

Empowering Veterans to Actively Communicate and Engage in Shared Decision Making in Medical Visits, A Randomized Controlled Trial

VA Office of Research and Development

NCT05169359

ACTIVE NOT RECRUITING 500 participants

Biological Sample Repository for Gastrointestinal Disorders

Pichamol Jirapinyo, MD, MPH

NCT05874726

ACTIVE NOT RECRUITING Phase 2 473 participants

Addressing Basic Needs to Improve Diabetes Outcomes in Medicaid Beneficiaries

Washington University School of Medicine

NCT03940209

ACTIVE NOT RECRUITING NA 378 participants

Decreasing Cardiovascular Risk for Patients With Diabetes

Michigan State University

NCT04874116

ACTIVE NOT RECRUITING NA 360 participants

Glucose Monitoring Comparison in Primary Care

HealthPartners Institute

NCT05222815

ACTIVE NOT RECRUITING NA 352 participants

Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology

Pennington Biomedical Research Center

NCT05523375

ACTIVE NOT RECRUITING NA 344 participants

Using Early Time Restricted Feeding and Timed Light Therapy to Improve Glycemic Control in Adults With Type 2 Diabetes

University of Alabama at Birmingham

NCT04155619

ACTIVE NOT RECRUITING NA 320 participants

Evaluating Telementoring for CHW-centered Diabetes Initiatives

The University of Texas Medical Branch, Galveston

NCT04835493

ACTIVE NOT RECRUITING NA 310 participants

A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus

University of California, Los Angeles

NCT04897945

ACTIVE NOT RECRUITING NA 304 participants

Food Delivery, Remote Monitoring, and Coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)

University of Alabama at Birmingham

NCT05288452

ACTIVE NOT RECRUITING NA 218 participants

Continuous Glucose Monitoring Devices in Hospitalized Veterans With Diabetes

VA Office of Research and Development

NCT03508934

ACTIVE NOT RECRUITING Phase 1 208 participants

A Family Dyad-focused Diabetes Self-Management Intervention for African American Adults

Ohio State University

NCT05905575

ACTIVE NOT RECRUITING NA 200 participants

Food As MedicinE for Diabetes

University of North Carolina, Chapel Hill

NCT04828785

ACTIVE NOT RECRUITING NA 198 participants

The Dietary Guidelines 3 Diet Patterns Study (DG3D): Phase 2

University of South Carolina

NCT05254496

ACTIVE NOT RECRUITING 172 participants

The HIV, Adipose Tissue Immunology, and Metabolism Study

Vanderbilt University Medical Center

NCT04451980

ACTIVE NOT RECRUITING NA 150 participants

Lowering Food Insecurity and Improving Diabetes With Financial Incentives

State University of New York at Buffalo

NCT05352022

ACTIVE NOT RECRUITING Phase 2 142 participants

A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy

Novo Nordisk A/S

NCT06797869

ACTIVE NOT RECRUITING NA 120 participants

Diabetes Discharge Transitional CGM Study (DDT-CGM)

Intermountain Health Care

NCT04729985

ACTIVE NOT RECRUITING Phase 2 120 participants

Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes

University of Alabama at Birmingham

NCT04542148

ACTIVE NOT RECRUITING NA 100 participants

Precision Diets for Diabetes Prevention

Stanford University

NCT03919877

ACTIVE NOT RECRUITING NA 100 participants

Mastering Diabetes Study

Ohio University

NCT04454957

ACTIVE NOT RECRUITING Phase 4 88 participants

Surgical or Medical Treatment

Children's Hospital Medical Center, Cincinnati

NCT04128995

ACTIVE NOT RECRUITING NA 60 participants

Electronic Diabetes Tune-Up Group (eDTU) for African Americans

Indiana University

NCT06321029

ACTIVE NOT RECRUITING Phase 1 49 participants

Study of Subcutaneously Administered ENT-03 for the Treatment of Obesity and Diabetes

Metabolics Pharma

NCT05925920

ACTIVE NOT RECRUITING NA 48 participants

Michigan Men's Diabetes Project 2

University of Michigan

NCT05370781

ACTIVE NOT RECRUITING 46 participants

Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans

University of Pittsburgh

NCT02710370

ACTIVE NOT RECRUITING 40 participants

Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics

Washington University School of Medicine

NCT03348280

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 38
Phase 3 74
Phase 4 26

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus, Type 2 Trial Landscape

351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).

Phase mix: 100 late (III/IV) vs 80 early (I/II).

Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus, Type 2?

PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus, Type 2?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.