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Transformative Research in Diabetic Nephropathy 2.0
NCT07444203 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this observational study is to learn more about kidney health in adults with diabetic kidney disease and other groups. Researchers will study kidney tissue and other samples. They want to learn how sodium-glucose cotransporter-2 (SGLT2) inhibitors, a type of diabetes medicine, may affect the kidneys. People can join only if they are already having a kidney biopsy or kidney surgery as part of their regular medical care. The main questions this study aims to answer are: * Do people who take SGLT2 inhibitors show different biological patterns in kidney tissue than similar people who do not take them? * Are these kidney tissue patterns linked with how kidney health changes over time? Researchers will compare participants who take SGLT2 inhibitors with similar participants who do not take these medicines. Participants will: Let researchers use one stored slide of kidney tissue from their regular care (no extra research biopsy) Give a blood sample and a urine sample Let researchers review medical record information over time
Conditions Studied
Interventions
- DRUG Sodium-glucose cotransporter 2 inhibitors (SGLT2i)
- DRUG Renin-angiotensin-aldosterone system blockade
- DRUG Glucagon-like peptide-1 receptor agonists (GLP 1 RA)
- DRUG Mineralocorticoid Receptor Antagonists(MRAs)
Study Locations (1)
Pennsylvania
- Penn Presbyterian Medical Center — Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2025-11-12 |
| Est. Completion | 2028-11-12 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07444203
The ClinicalTrials.gov registry entry for NCT07444203 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pennsylvania, which has 1,457 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Diabetes Mellitus, Type 2 appearing as the primary indexed condition, and to 4 interventions — of which Sodium-glucose cotransporter 2 inhibitors (SGLT2i) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07444203 reports 1 study location spanning 1 distinct geographic area — top geographies include Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07444203 about?
NCT07444203 is a clinical study titled "Transformative Research in Diabetic Nephropathy 2.0". The goal of this observational study is to learn more about kidney health in adults with diabetic kidney disease and other groups. Researchers will study kidney tissue and other samples. They want to learn how sodium-glucose cotransporter-2 (SGLT2) inhibitors, a type of diabetes medicine, may affect...
What is the current status of trial NCT07444203?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2025-11-12. Estimated completion is 2028-11-12.
What conditions does trial NCT07444203 study?
This clinical trial studies the following conditions: Diabetes Mellitus, Type 2, Kidney Diseases, Renal Insufficiency, Chronic, Diabetic Nephropathies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07444203?
The interventions under investigation include: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) (DRUG), Renin-angiotensin-aldosterone system blockade (DRUG), Glucagon-like peptide-1 receptor agonists (GLP 1 RA) (DRUG), Mineralocorticoid Receptor Antagonists(MRAs) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07444203?
This trial is sponsored by University of Pennsylvania, which has 1,457 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07444203 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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