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ClinicalTrials.gov 57 recruiting now official registry

Coronary Artery Disease clinical trials

57 of 220 indexed Coronary Artery Disease trials are currently recruiting.

220 US clinical trials · 57 currently recruiting

Coronary Artery Disease is the subject of 220 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 42 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 17 of these trials.

The research picture

Coronary Artery Disease has 220 registered US clinical trials, 57 of them open to new participants right now, about 26% of the total.

57
recruiting participants now
26%
of trials open to enrollment
42
in Phase 3–4 (later-stage)
17
top sponsor: University of Florida
Phase 16Phase 29Phase 317Phase 425

Active & Recent Trials

220 total, page 1 of 5

RECRUITING NA 5,100 participants

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

Population Health Research Institute

NCT05701358

RECRUITING 5,000 participants

Factors Affect Outcomes in Cardiovascular Surgery

University of California, Davis

NCT01932411

RECRUITING 4,000 participants

Progress Bifurcation Global Registry

Minneapolis Heart Institute Foundation

NCT05100992

RECRUITING 4,000 participants

Progress Complication

Minneapolis Heart Institute Foundation

NCT05100940

RECRUITING NA 4,000 participants

Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

University of British Columbia

NCT04634240

RECRUITING NA 2,500 participants

Assessment of Patients With suspeCted Coronary Artery Disease by Coronary calciUm fiRst strATegy vErsus Usual Care Approach.

Intermountain Health Care

NCT03972774

RECRUITING NA 2,300 participants

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

Weill Medical College of Cornell University

NCT04124120

RECRUITING NA 1,605 participants

MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels

Concept Medical

NCT06271590

RECRUITING NA 1,500 participants

AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

Brigham and Women's Hospital

NCT06235112

RECRUITING NA 1,205 participants

Prevail Global Study

Medtronic Vascular

NCT06535854

RECRUITING 1,000 participants

Cardiovascular Innovation & Research Institute 's NEXUS Registry, the Whole is Greater Than the Parts.

Cardiovascular Innovation and Research Institute

NCT03428048

RECRUITING 1,000 participants

Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure

Semmelweis University

NCT07016477

RECRUITING NA 1,000 participants

A Randomized Comparison of Personalized Therapy Mgmt Based On Coronary Atherosclerotic Plaque Vs. Usual Care for Symptomatic Patients With Suspicion of CAD

Cleerly

NCT06713239

RECRUITING NA 960 participants

SELUTION 4 De Novo Small Vessel IDE Trial

M.A. Med Alliance S.A.

NCT05946629

RECRUITING NA 842 participants

CTSN Embolic Protection Trial

Icahn School of Medicine at Mount Sinai

NCT06027788

RECRUITING NA 824 participants

RADIQAL Study (Radiation Dose and Image Quality Trial)

Philips Clinical & Medical Affairs Global

NCT06944509

RECRUITING NA 754 participants

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

Sunnybrook Health Sciences Centre

NCT05427370

RECRUITING NA 740 participants

Virtue® SAB in the Treatment of Coronary ISR Trial

Orchestra BioMed

NCT07045194

RECRUITING Phase 4 700 participants

The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial

VA Office of Research and Development

NCT05618353

RECRUITING NA 700 participants

A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

Fundación EPIC

NCT07286578

RECRUITING Phase 3 600 participants

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women

Weill Medical College of Cornell University

NCT06399692

RECRUITING Phase 3 600 participants

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

Weill Medical College of Cornell University

NCT06399705

RECRUITING NA 516 participants

MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation

University of California, San Francisco

NCT05933083

RECRUITING NA 500 participants

Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health

Massachusetts General Hospital

NCT07087431

RECRUITING 500 participants

A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction

University of Florida

NCT05332262

RECRUITING NA 492 participants

MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

Concept Medical

NCT05908331

RECRUITING NA 450 participants

Clinical Impact of Cardiac Photon Counting CT

Mayo Clinic

NCT05240807

RECRUITING NA 388 participants

Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

University of Tennessee

NCT06374277

RECRUITING NA 335 participants

TECTONIC CAD IVL IDE Study

Abbott Medical Devices

NCT06885177

RECRUITING NA 310 participants

PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

Kardion

NCT06445608

RECRUITING Phase 3 300 participants

A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque

NewAmsterdam Pharma

NCT06305559

RECRUITING 300 participants

South Asians and Coronary Plaque Registry

University of Texas Southwestern Medical Center

NCT05367297

RECRUITING Phase 4 300 participants

Etomidate Versus Propofol in CABG Surgery

Hartford Hospital

NCT06068764

RECRUITING Phase 2 242 participants

Prevent Cardiac Surgery Associated AKI Trial

George Washington University

NCT06620523

RECRUITING Phase 3 215 participants

RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)

MedTrace Pharma A/S

NCT05134012

RECRUITING NA 200 participants

Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health

Massachusetts General Hospital

NCT05819814

RECRUITING Phase 4 200 participants

Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine

Massachusetts General Hospital

NCT05850091

RECRUITING NA 200 participants

Digital Monitoring for Patients Post Coronary Interventions to Reduce Risk for Recurrent Adverse Cardiovascular Events

University of California, Davis

NCT06114615

RECRUITING 189 participants

PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG

Aventusoft

NCT06567795

RECRUITING NA 176 participants

The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial

Ottawa Heart Institute Research Corporation

NCT03447938

RECRUITING NA 150 participants

Safety and Effectiveness of the Orsiro Mission 48-mm Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

Teleflex

NCT06779630

RECRUITING NA 120 participants

Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment

Annapoorna Kini

NCT07000045

RECRUITING NA 120 participants

Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia

Mayo Clinic

NCT05111288

RECRUITING 107 participants

Physiological Assessment of Severe Coronary Stenosis for Informing Planned PCI

Beth Israel Deaconess Medical Center

NCT05491668

RECRUITING Phase 2 106 participants

Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.

XyloCor Therapeutics

NCT07048808

RECRUITING Phase 4 90 participants

Tailoring Bleeding Reduction Approaches in Patients Undergoing PCI

University of Florida

NCT05681702

RECRUITING Phase 4 78 participants

Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI: The Switching Antiplatelet-8 (SWAP-8) Study

University of Florida

NCT06821191

RECRUITING 50 participants

Study of Hepatitis Eradication Receiving Protease Inhibitor Administration

Sentara Norfolk General Hospital

NCT03886077

RECRUITING Phase 4 50 participants

Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention

University of Florida

NCT06228456

RECRUITING Phase 4 48 participants

Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors

University of Florida

NCT06691191

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 9
Phase 3 17
Phase 4 25

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Coronary Artery Disease Trial Landscape

220 indexed Coronary Artery Disease studies · 57 recruiting (26%).

Phase mix: 42 late (III/IV) vs 15 early (I/II).

Top sponsor: University of Florida (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Coronary Artery Disease?

PlainTrial tracks 220 US clinical trials for Coronary Artery Disease, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Coronary Artery Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.