Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
NCT03447938 · View on ClinicalTrials.gov ↗
Study Summary
MICS CABG (Minimally invasive coronary surgery), where coronary artery bypass grafting (CABG) is completed through a small incision over the left chest, has evolved to become a safe and less invasive alternative to conventional sternotomy CABG. Several observational studies have suggested significantly shorter time to return to physical activity for MICS CABG patients compared to sternotomy CABG patients. A randomized study is warranted to validate these findings, provide higher level of evidence, and potentially lead to changes in practice. The MIST Trial is a multi-centre, prospective, open label, randomized control trial comparing quality of life and recovery in the early post-operative period, between patients undergoing MICS CABG versus patients undergoing sternotomy CABG. Patients referred for isolated CABG for multi-vessel coronary artery disease and deemed technically suitable for sternotomy CABG as well as for MICS CABG are considered for enrollment into the trial. Quality of life questionnaires (The SF-36, Seattle Angina Questionnaire and EQ-5D-5L) will be used to assess the quality of life and recovery in patients undergoing sternotomy CABG or MICS CABG at 1 month, 3 months, 6 months and 12 months follow up.
Conditions Studied
Interventions
- PROCEDURE MICS CABG
- PROCEDURE Conventional CABG
Study Locations (13)
Other
- Universitaire Ziekenhuizen Leuven — Leuven
- Robert-Bosch-Hospital — Stuttgart
- National University Hospital (NUH) - Singapore — Singapore
- Far-Eastern Memorial Hospital — Taipei
Ontario
- Division of Cardiac Surgery, University of Ottawa Heart Institute — Ottawa
- University Health Network — Toronto
Pennsylvania
- University of Pittsburgh Medical Center — Pittsburgh
Wisconsin
- Gundersen Lutheran Medical Center — La Crosse
Jilin
- Jilin Heart Hospital — Jilin
Saxony
- Leipzig Heart Institute GmbH — Leipzig
Karnataka
- Apollo Hospital, Bangalore — Bangalore
National Capital Territory of Delhi
- Manipal Hospitals — New Delhi
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 176 participants |
| Start Date | 2018-09-01 |
| Est. Completion | 2028-03-01 |
| Phase | NA |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03447938
The ClinicalTrials.gov registry entry for NCT03447938 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 176 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ottawa Heart Institute Research Corporation, which has 34 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Coronary Artery Disease appearing as the primary indexed condition, and to 2 interventions — of which MICS CABG is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03447938 reports 13 study locations spanning 9 distinct geographic areas — top geographies include Other, Ontario, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03447938 about?
NCT03447938 is a clinical study titled "The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial". MICS CABG (Minimally invasive coronary surgery), where coronary artery bypass grafting (CABG) is completed through a small incision over the left chest, has evolved to become a safe and less invasive alternative to conventional sternotomy CABG. Several observational studies have suggested significan...
What is the current status of trial NCT03447938?
This trial is currently recruiting. It is a NA study. The enrollment target is 176 participants. The study started on 2018-09-01. Estimated completion is 2028-03-01.
What conditions does trial NCT03447938 study?
This clinical trial studies the following conditions: Coronary Artery Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03447938?
The interventions under investigation include: MICS CABG (PROCEDURE), Conventional CABG (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03447938?
This trial is sponsored by Ottawa Heart Institute Research Corporation, which has 34 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03447938 being conducted?
This trial has 13 study locations across Pennsylvania, Wisconsin, Ontario, Jilin, Saxony. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.