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ClinicalTrials.gov 57 recruiting now official registry

Coronary Artery Disease clinical trials

57 of 220 indexed Coronary Artery Disease trials are currently recruiting.

220 US clinical trials · 57 currently recruiting

Coronary Artery Disease is the subject of 220 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 42 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 17 of these trials.

The research picture

Coronary Artery Disease has 220 registered US clinical trials, 57 of them open to new participants right now, about 26% of the total.

57
recruiting participants now
26%
of trials open to enrollment
42
in Phase 3–4 (later-stage)
17
top sponsor: University of Florida
Phase 16Phase 29Phase 317Phase 425

Active & Recent Trials

220 total, page 2 of 5

RECRUITING NA 33 participants

PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]

Johns Hopkins University

NCT05994014

RECRUITING 30 participants

Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability

University of Texas Southwestern Medical Center

NCT06047028

RECRUITING NA 30 participants

Clinical and Biochemical Effects of a Defined Plant-Based Diet on Heart Disease

Georgia State University

NCT06994624

RECRUITING NA 30 participants

Acceptance and Commitment Therapy for Patients Undergoing Coronary Artery Bypass Graft Surgery

University of Iowa

NCT06207318

RECRUITING NA 25 participants

Evaluating Infrasonic Hemodynography

Scripps Health

NCT04636892

RECRUITING NA 24 participants

Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function

University of Florida

NCT04920799

RECRUITING 15 participants

Hyperpolarized 13C Pyruvate-MRI and FDG-PET in a Single Exam for the Prognosis of Ischemic Cardiomyopathy

University of Texas Southwestern Medical Center

NCT06814587

ACTIVE NOT RECRUITING 30,000 participants

Database Registry of the Intermountain Heart Collaborative Study

Intermountain Health Care

NCT00406185

ACTIVE NOT RECRUITING 20,000 participants

AI DErived Plaque Quantification: CCTA and AI-QCPA for Determining Effective CAD Management

HeartFlow

NCT06376851

ACTIVE NOT RECRUITING 15,000 participants

Genomic Investigation of Cardiovascular Diseases

Scripps Translational Science Institute

NCT00722748

ACTIVE NOT RECRUITING 5,764 participants

PRE-DETERMINE Cohort Study

Brigham and Women's Hospital

NCT01114269

ACTIVE NOT RECRUITING NA 4,300 participants

Randomization of Single vs Multiple Arterial Grafts

Weill Medical College of Cornell University

NCT03217006

ACTIVE NOT RECRUITING Phase 4 2,476 participants

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

University of Florida

NCT03417388

ACTIVE NOT RECRUITING 2,314 participants

Mediators of Atherosclerosis in South Asians Living in America

University of California, San Francisco

NCT01207167

ACTIVE NOT RECRUITING NA 1,720 participants

Firehawk Rapamycin Target Eluting Coronary Stent North American Trial

Shanghai MicroPort Medical (Group) Co.

NCT04562532

ACTIVE NOT RECRUITING 1,643 participants

Precision PCI Registry

University of Florida

NCT06143709

ACTIVE NOT RECRUITING 1,500 participants

Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 3 Extended

Stanford University

NCT07308860

ACTIVE NOT RECRUITING NA 1,252 participants

Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

Abiomed

NCT04763200

ACTIVE NOT RECRUITING NA 1,090 participants

Precise Procedural and PCI Plan (P4)

CoreAalst

NCT05253677

ACTIVE NOT RECRUITING NA 1,085 participants

Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease

The University of Texas Health Science Center, Houston

NCT00756379

ACTIVE NOT RECRUITING Phase 3 900 participants

PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients

Beth Israel Deaconess Medical Center

NCT04093219

ACTIVE NOT RECRUITING NA 800 participants

Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health

American College of Radiology

NCT06055972

ACTIVE NOT RECRUITING Phase 3 610 participants

Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events

Novartis Pharmaceuticals

NCT05360446

ACTIVE NOT RECRUITING NA 440 participants

Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients

University of Sao Paulo General Hospital

NCT02338947

ACTIVE NOT RECRUITING NA 420 participants

Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)

Bolt Medical

NCT06181240

ACTIVE NOT RECRUITING 399 participants

Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease

Shockwave Medical

NCT05755711

ACTIVE NOT RECRUITING 368 participants

Long Term Follow Up for CTSN Mitral Valve Repair Studies

Icahn School of Medicine at Mount Sinai

NCT03066050

ACTIVE NOT RECRUITING NA 276 participants

The Precision CAD Trial

Emory University

NCT04755413

ACTIVE NOT RECRUITING NA 160 participants

Reducing Metabolic Dysregulation in Obese Latina Breast Cancer Survivors Using Physical Activity

Dana-Farber Cancer Institute

NCT04717050

ACTIVE NOT RECRUITING 102 participants

XIENCE Skypoint Large Vessel Post Approval Study

Abbott Medical Devices

NCT05423379

ACTIVE NOT RECRUITING 70 participants

Vis-Rx Prime Micro-Imaging Catheter Study

Gentuity

NCT06685783

ACTIVE NOT RECRUITING 68 participants

Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics

University of Cincinnati

NCT01719016

ACTIVE NOT RECRUITING NA 60 participants

The Young Heart Study

Northwell Health

NCT04462159

ACTIVE NOT RECRUITING NA 48 participants

A Sugar-Sweetened Beverage Reduction Intervention for Native American Men

Roswell Park Cancer Institute

NCT06029517

ACTIVE NOT RECRUITING NA 40 participants

Intraoperative Echocardiography in Low-Risk CABG Surgery

University of Pennsylvania

NCT06154265

ACTIVE NOT RECRUITING NA 40 participants

Short Interval Resveratrol Trial in Cardiovascular Surgery

MaineHealth

NCT03762096

ACTIVE NOT RECRUITING NA 28 participants

Impact of Time Restricted Eating on Patients With Coronary Artery Disease (CAD) Undergoing Cardiac Rehabilitation

University of California, San Diego

NCT05014880

COMPLETED 30,000 participants

The xDAPT External Validation Study

Icahn School of Medicine at Mount Sinai

NCT06736626

COMPLETED 19,000 participants

Patient Centered Machine Learning Model for Bleeding and Ischemic Risk

Abbott Medical Devices

NCT06089304

COMPLETED NA 9,501 participants

Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications

University of Colorado, Denver

NCT03973931

COMPLETED 8,575 participants

Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents

Cardiovascular Research Foundation, New York

NCT00638794

COMPLETED 6,000 participants

Physicians International Coronary Computed Tomography Angiography (CCTA) Utilization Registry

MDDX

NCT00932958

COMPLETED NA 5,179 participants

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

NYU Langone Health

NCT01471522

COMPLETED 5,034 participants

XIENCE V® Everolimus Eluting Coronary Stent System USA Post-Approval Study (XIENCE V® USA Long Term Follow-up Cohort)

Abbott Medical Devices

NCT01120379

COMPLETED 4,350 participants

Personalized Risk Evaluation and Diagnosis (Using Corus CAD or ASGES) in the Coronary Tree

CardioDx

NCT00500617

COMPLETED Phase 3 4,000 participants

Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II)

Alexion Pharmaceuticals

NCT00088179

COMPLETED Phase 3 3,687 participants

SPIRIT IV Clinical Trial: Clinical Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System

Abbott Medical Devices

NCT00307047

COMPLETED NA 3,000 participants

Improving Quality With Outpatient Decision Support

Agency for Healthcare Research and Quality (AHRQ)

NCT00225628

COMPLETED NA 2,500 participants

TC-WYRE: TAXUS Express Stent vs. Cypher Stent - What's Your Real Life Experience?

Boston Scientific Corporation

NCT00344630

COMPLETED 2,322 participants

Inclusive Invasive Physiological Assessment in Angina Syndromes Registry

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

NCT04485234

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 9
Phase 3 17
Phase 4 25

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Coronary Artery Disease Trial Landscape

220 indexed Coronary Artery Disease studies · 57 recruiting (26%).

Phase mix: 42 late (III/IV) vs 15 early (I/II).

Top sponsor: University of Florida (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Coronary Artery Disease?

PlainTrial tracks 220 US clinical trials for Coronary Artery Disease, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Coronary Artery Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.