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NCT05427370 · ClinicalTrials.gov registry record · NA

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

A NA study of Coronary Artery Disease and Heart Failure, Systolic, sponsored by Sunnybrook Health Sciences Centre.

Recruiting
Registry status
NA
Development phase
754
Enrollment target
20
Study locations

NCT05427370 is a NA study of Coronary Artery Disease and Heart Failure, Systolic that is actively recruiting participants, run by Sunnybrook Health Sciences Centre. The registered enrollment target is 754 participants, below the 1,284-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (41% lower). The trial reports 20 study locations across 11 states.

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The verdict

NCT05427370, a NA study of Coronary Artery Disease and Heart Failure, Systolic, is actively recruiting participants, sponsored by Sunnybrook Health Sciences Centre.

RECRUITING
Registry status
NA
Development phase
754 participants
Enrollment target
20
Study locations

Study Summary

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether CABG compared to PCI is associated with a reduction in all-cause death, stroke, spontaneous myocardial infarction (MI), urgent repeat revascularization (RR), or heart failure (HF) readmission over a median follow-up of 5 years in patients with multivessel/LM CAD and ischemic left ventricular dysfunction (iLVSD). Eligible patients are considered by the local Heart Team appropriate and amenable for non-emergent revascularization by both modes of revascularization. The secondary objectives are to describe the early risks of both procedures, and a comprehensive set of patient-reported outcomes longitudinally.

Conditions Studied

Coronary Artery Disease Heart Failure, Systolic

Interventions

  • PROCEDURE Revascularization by PCI
  • PROCEDURE Revascularization by CABG

Study Locations (20)

Ontario

  • Hamilton General Hospital - Hamilton
  • London Health Sciences Center, University Hospital - London
  • Southlake Regional HC - Newmarket
  • Ottawa Heart Institute - Ottawa
  • Sunnybrook Health Sciences Center - Toronto
  • St. Michael's - Toronto
  • Toronto General Hospital - Toronto

Other

  • Medical University of Vienna - Vienna
  • Heart Institute, Medical School of the University of Sao Paulo_INCOR - São Paulo

Alberta

  • University of Calgary; Libin Cardiovascular Institute - Calgary
  • Mackenzie Health Sciences Center - Edmonton

British Columbia

  • Fraser Health; Royal Columbian Hospital - New Westminster
  • Providence Health - Vancouver

California

  • Cedars-Sinai - Los Angeles

Connecticut

  • Yale University - New Haven

Kentucky

  • UofL Health, Inc - Louisville

Maryland

  • John Hopkins Hospital - Baltimore

Trial Details

FieldValue
Enrollment Target 754 participants
Start Date 2023-06-22
Est. Completion 2029-12
Phase NA

Sponsor

Sunnybrook Health Sciences Centre

7 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05427370

The ClinicalTrials.gov registry entry for NCT05427370 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 754 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,284-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (41% lower). The listed sponsor is Sunnybrook Health Sciences Centre, which has 7 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Coronary Artery Disease appearing as the primary indexed condition, and to 2 interventions - of which Revascularization by PCI is the first listed.

NCT05427370 reports 20 study locations spanning 11 distinct geographic areas - top geographies include Ontario, Other, Alberta.

Frequently Asked Questions

What is clinical trial NCT05427370 about?

NCT05427370 is a clinical study titled "The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)". The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery ...

What is the current status of trial NCT05427370?

This trial is currently recruiting. It is a NA study. The enrollment target is 754 participants. The study started on 2023-06-22. Estimated completion is 2029-12.

What conditions does trial NCT05427370 study?

This clinical trial studies the following conditions: Coronary Artery Disease, Heart Failure, Systolic.

What interventions are being tested in trial NCT05427370?

The interventions under investigation include: Revascularization by PCI (PROCEDURE), Revascularization by CABG (PROCEDURE).

Who is sponsoring clinical trial NCT05427370?

This trial is sponsored by Sunnybrook Health Sciences Centre, which has 7 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05427370 being conducted?

This trial has 20 study locations across California, Connecticut, Kentucky, Maryland, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.