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Coronary Artery Disease
Open-data reference.
220 US clinical trials · 57 currently recruiting
Active & Recent Trials
Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
Population Health Research Institute
NCT05701358
Factors Affect Outcomes in Cardiovascular Surgery
University of California, Davis
NCT01932411
Progress Bifurcation Global Registry
Minneapolis Heart Institute Foundation
NCT05100992
Progress Complication
Minneapolis Heart Institute Foundation
NCT05100940
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
University of British Columbia
NCT04634240
Assessment of Patients With suspeCted Coronary Artery Disease by Coronary calciUm fiRst strATegy vErsus Usual Care Approach.
Intermountain Health Care
NCT03972774
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Weill Medical College of Cornell University
NCT04124120
MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels
Concept Medical
NCT06271590
AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention
Brigham and Women's Hospital
NCT06235112
Prevail Global Study
Medtronic Vascular
NCT06535854
Cardiovascular Innovation & Research Institute 's NEXUS Registry, the Whole is Greater Than the Parts.
Cardiovascular Innovation and Research Institute
NCT03428048
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure
Semmelweis University
NCT07016477
A Randomized Comparison of Personalized Therapy Mgmt Based On Coronary Atherosclerotic Plaque Vs. Usual Care for Symptomatic Patients With Suspicion of CAD
Cleerly
NCT06713239
SELUTION 4 De Novo Small Vessel IDE Trial
M.A. Med Alliance S.A.
NCT05946629
CTSN Embolic Protection Trial
Icahn School of Medicine at Mount Sinai
NCT06027788
RADIQAL Study (Radiation Dose and Image Quality Trial)
Philips Clinical & Medical Affairs Global
NCT06944509
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
Sunnybrook Health Sciences Centre
NCT05427370
Virtue® SAB in the Treatment of Coronary ISR Trial
Orchestra BioMed
NCT07045194
The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial
VA Office of Research and Development
NCT05618353
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
Fundación EPIC
NCT07286578
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women
Weill Medical College of Cornell University
NCT06399692
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities
Weill Medical College of Cornell University
NCT06399705
MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation
University of California, San Francis
NCT05933083
Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health
Massachusetts General Hospital
NCT07087431
A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction
University of Florida
NCT05332262
MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions
Concept Medical
NCT05908331
Clinical Impact of Cardiac Photon Counting CT
Mayo Clinic
NCT05240807
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
University of Tennessee
NCT06374277
TECTONIC CAD IVL IDE Study
Abbott Medical Devices
NCT06885177
PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm
Kardion
NCT06445608
A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque
NewAmsterdam Pharma
NCT06305559
South Asians and Coronary Plaque Registry
University of Texas Southwestern Medical Center
NCT05367297
Etomidate Versus Propofol in CABG Surgery
Hartford Hospital
NCT06068764
Prevent Cardiac Surgery Associated AKI Trial
George Washington University
NCT06620523
RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)
MedTrace Pharma A/S
NCT05134012
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
Massachusetts General Hospital
NCT05819814
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine
Massachusetts General Hospital
NCT05850091
Digital Monitoring for Patients Post Coronary Interventions to Reduce Risk for Recurrent Adverse Cardiovascular Events
University of California, Davis
NCT06114615
PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG
Aventusoft
NCT06567795
The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
Ottawa Heart Institute Research Corporation
NCT03447938
Safety and Effectiveness of the Orsiro Mission 48-mm Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions
Teleflex
NCT06779630
Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment
Annapoorna Kini
NCT07000045
Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia
Mayo Clinic
NCT05111288
Physiological Assessment of Severe Coronary Stenosis for Informing Planned PCI
Beth Israel Deaconess Medical Center
NCT05491668
Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.
XyloCor Therapeutics
NCT07048808
Tailoring Bleeding Reduction Approaches in Patients Undergoing PCI
University of Florida
NCT05681702
Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI: The Switching Antiplatelet-8 (SWAP-8) Study
University of Florida
NCT06821191
Study of Hepatitis Eradication Receiving Protease Inhibitor Administration
Sentara Norfolk General Hospital
NCT03886077
Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention
University of Florida
NCT06228456
Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors
University of Florida
NCT06691191
PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]
Johns Hopkins University
NCT05994014
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
University of Texas Southwestern Medical Center
NCT06047028
Clinical and Biochemical Effects of a Defined Plant-Based Diet on Heart Disease
Georgia State University
NCT06994624
Acceptance and Commitment Therapy for Patients Undergoing Coronary Artery Bypass Graft Surgery
University of Iowa
NCT06207318
Evaluating Infrasonic Hemodynography
Scripps Health
NCT04636892
Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function
University of Florida
NCT04920799
Hyperpolarized 13C Pyruvate-MRI and FDG-PET in a Single Exam for the Prognosis of Ischemic Cardiomyopathy
University of Texas Southwestern Medical Center
NCT06814587
Database Registry of the Intermountain Heart Collaborative Study
Intermountain Health Care
NCT00406185
AI DErived Plaque Quantification: CCTA and AI-QCPA for Determining Effective CAD Management
HeartFlow
NCT06376851
Genomic Investigation of Cardiovascular Diseases
Scripps Translational Science Institute
NCT00722748
PRE-DETERMINE Cohort Study
Brigham and Women's Hospital
NCT01114269
Randomization of Single vs Multiple Arterial Grafts
Weill Medical College of Cornell University
NCT03217006
Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD
University of Florida
NCT03417388
Mediators of Atherosclerosis in South Asians Living in America
University of California, San Francis
NCT01207167
Firehawk Rapamycin Target Eluting Coronary Stent North American Trial
Shanghai MicroPort Medical (Group) Co.
NCT04562532
Precision PCI Registry
University of Florida
NCT06143709
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 3 Extended
Stanford University
NCT07308860
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
Abiomed
NCT04763200
Precise Procedural and PCI Plan (P4)
CoreAalst
NCT05253677
Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease
The University of Texas Health Science Center, Houston
NCT00756379
PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients
Beth Israel Deaconess Medical Center
NCT04093219
Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health
American College of Radiology
NCT06055972
Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
Novartis Pharmaceuticals
NCT05360446
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients
University of Sao Paulo General Hospital
NCT02338947
Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)
Bolt Medical
NCT06181240
Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease
Shockwave Medical
NCT05755711
Long Term Follow Up for CTSN Mitral Valve Repair Studies
Icahn School of Medicine at Mount Sinai
NCT03066050
The Precision CAD Trial
Emory University
NCT04755413
Reducing Metabolic Dysregulation in Obese Latina Breast Cancer Survivors Using Physical Activity
Dana-Farber Cancer Institute
NCT04717050
XIENCE Skypoint Large Vessel Post Approval Study
Abbott Medical Devices
NCT05423379
Vis-Rx Prime Micro-Imaging Catheter Study
Gentuity
NCT06685783
Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
University of Cincinnati
NCT01719016
The Young Heart Study
Northwell Health
NCT04462159
A Sugar-Sweetened Beverage Reduction Intervention for Native American Men
Roswell Park Cancer Institute
NCT06029517
Intraoperative Echocardiography in Low-Risk CABG Surgery
University of Pennsylvania
NCT06154265
Short Interval Resveratrol Trial in Cardiovascular Surgery
MaineHealth
NCT03762096
Impact of Time Restricted Eating on Patients With Coronary Artery Disease (CAD) Undergoing Cardiac Rehabilitation
University of California, San Diego
NCT05014880
The xDAPT External Validation Study
Icahn School of Medicine at Mount Sinai
NCT06736626
Patient Centered Machine Learning Model for Bleeding and Ischemic Risk
Abbott Medical Devices
NCT06089304
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
University of Colorado, Denver
NCT03973931
Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents
Cardiovascular Research Foundation, New York
NCT00638794
Physicians International Coronary Computed Tomography Angiography (CCTA) Utilization Registry
MDDX
NCT00932958
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
NYU Langone Health
NCT01471522
XIENCE V® Everolimus Eluting Coronary Stent System USA Post-Approval Study (XIENCE V® USA Long Term Follow-up Cohort)
Abbott Medical Devices
NCT01120379
Personalized Risk Evaluation and Diagnosis (Using Corus CAD or ASGES) in the Coronary Tree
CardioDx
NCT00500617
Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II)
Alexion Pharmaceuticals
NCT00088179
SPIRIT IV Clinical Trial: Clinical Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System
Abbott Medical Devices
NCT00307047
Improving Quality With Outpatient Decision Support
Agency for Healthcare Research and Quality (AHRQ)
NCT00225628
TC-WYRE: TAXUS Express Stent vs. Cypher Stent - What's Your Real Life Experience?
Boston Scientific Corporation
NCT00344630
Inclusive Invasive Physiological Assessment in Angina Syndromes Registry
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT04485234
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 6 |
| Phase 2 | 9 |
| Phase 3 | 17 |
| Phase 4 | 25 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Coronary Artery Disease Trial Landscape
ClinicalTrials.gov lists 220 US studies indexed under Coronary Artery Disease, and 57 of those are currently open to recruitment — roughly 26% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Coronary Artery Disease shows 42 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Coronary Artery Disease is led by University of Florida with 17 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Coronary Artery Disease?
PlainTrial tracks 220 US clinical trials for Coronary Artery Disease, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Coronary Artery Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.