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NCT06891755 · ClinicalTrials.gov registry record · NA
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
A NA study of COPD and Emphysema, sponsored by Apreo Health.
- Recruiting
- Registry status
- NA
- Development phase
- 250
- Enrollment target
- 19
- Study locations
NCT06891755: Recruiting NA study of COPD and Emphysema, sponsored by Apreo Health.
NCT06891755 is a NA study of COPD and Emphysema that is actively recruiting participants, run by Apreo Health. The registered enrollment target is 250 participants, below the 2,415-participant average among 85 other COPD trials with a reported enrollment target (90% lower). The trial reports 19 study locations across 13 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06891755, a NA study of COPD and Emphysema, is actively recruiting participants, sponsored by Apreo Health.
- RECRUITING
- Registry status
- NA
- Development phase
- 250 participants
- Enrollment target
- 19
- Study locations
Study Summary
The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphysema suffering from dyspnea due to hyperinflation despite optimal medical treatment. The Apreo BREATHE Airway Scaffold is a permanent implant designed to tent open native airways. The study will include up to 250 participants at up to 25 study centers located in the United States and Europe. Study subjects will be followed for 3 years. The main questions it aims to answer are: Is it safe? Does it work?
Primary Outcome
Defined as a subject who experiences a reduction from baseline in post-bronchodilator FEV1 of ≥12%
Interventions
- DEVICE Apreo BREATHE Airway Scaffold
- OTHER Optimal Medical Management (OMM)
Study Locations (19)
Pennsylvania
- Clinical Research Associates of Central Pennsylvania - DuBois
- Temple University - Philadelphia
- University of Pittsburgh Medical Center - Pittsburgh
Florida
- Mayo Clinic - Jacksonville
- Orlando Health - Orlando
Illinois
- University of Chicago - Chicago
- OSF St Francis Medical Center - Peoria
Ohio
- Cleveland Clinic Foundation - Cleveland
- The Ohio State University - Columbus
Other
- University Medical Center Groningen - Groningen
- Royal Brompton Hospital - London
Alabama
- University of Alabama at Birmingham - Birmingham
Arizona
- Banner Health - Gilbert
California
- University of California at Davis - Sacramento
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2025-07-15 |
| Est. Completion | 2029-12-31 |
| Phase | NA |
What NCT06891755 shows while recruiting
NCT06891755 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 2,415-participant average among 85 other COPD trials with a reported enrollment target (90% lower).
The record links to 2 conditions, with COPD appearing as the primary indexed condition, and to 2 interventions - of which Apreo BREATHE Airway Scaffold is the first listed.
NCT06891755 lists 19 locations in 13 states (Pennsylvania, Florida, Illinois).
Frequently Asked Questions
What is clinical trial NCT06891755 about?
NCT06891755 is a clinical study titled "Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3". The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphysema suffering from dyspnea due to hyperinflation despite optimal medical treatment. The Apreo BREATH...
What is the current status of trial NCT06891755?
This trial is currently recruiting. It is a NA study. The enrollment target is 250 participants. The study started on 2025-07-15. Estimated completion is 2029-12-31.
What conditions does trial NCT06891755 study?
This clinical trial studies the following conditions: COPD, Emphysema.
What interventions are being tested in trial NCT06891755?
The interventions under investigation include: Apreo BREATHE Airway Scaffold (DEVICE), Optimal Medical Management (OMM) (OTHER).
Who is sponsoring clinical trial NCT06891755?
This trial is sponsored by Apreo Health, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06891755 being conducted?
This trial has 19 study locations across Alabama, Arizona, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06891755's enrollment target sits among peer trials
250 28th of 85 higher than 58 of 85 other COPD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COPD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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