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NCT01640288 · ClinicalTrials.gov registry record · Phase 1
Imaging Regional Lung Defect Severity
A Phase 1 study of COPD, sponsored by Hal C Charles.
- Completed
- Registry status
- Phase 1
- Development phase
- 171
- Enrollment target
- 1
- Study location
NCT01640288: Completed Phase 1 study of COPD, sponsored by Hal C Charles.
NCT01640288 is a Phase 1 study of COPD that has completed, run by Hal C Charles. The registered enrollment target is 171 participants, below the 2,416-participant average among 85 other COPD trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01640288, a Phase 1 study of COPD, has completed, sponsored by Hal C Charles.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 171 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to develop and evaluate the usefulness of magnetic resonance imaging (MRI) using inert perfluorinated gases mixed with oxygen for regional assessment of pulmonary function. The proposed study seeks to determine regional qualitative and quantitative lung function information in the context of the clinical trajectory of chronic obstructive pulmonary disease (COPD) defined by the cross sectional cohort component. In the case of these perfluorinated (PFx)/oxygen mixtures, the availability of multi-liter quantities allows for wash-in/wash-out image acquisition and analysis allowing direct measures of gas trapping in a manner not easily achieved with any existing modality.
Primary Outcome
Determine quantitative measures of lung ventilation performance in terms of direct measures of gas trapping measured during washout of the perfluorinated gas mixture. Measurement of 'gas trapping' was accomplished using fractional lung volume fast and slow filling compartments. Fractional lung volumes are derived from the MRI (lung volume with fast or slow filling/total MR volume elements in the lung field defined by the gas imaging). All data is normalized per subject to the total lung volume o
Conditions Studied
Interventions
- DRUG Perfluorinated Gas/Oxygen Mixture
- OTHER High Resolution CT of the Chest
Study Locations (1)
North Carolina
- Duke Image Analysis Laboratory - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 171 participants |
| Start Date | 2013-01 |
| Est. Completion | 2018-08-10 |
| Phase | Phase 1 |
What the finished NCT01640288 record still lists
NCT01640288 is an interventional study that assigns participants to a tested intervention. The registered 171 participants enrollment target is mid-sized for trials with a published cap, below the 2,416-participant average among 85 other COPD trials with a reported enrollment target (93% lower).
The record links to 1 condition, with COPD appearing as the primary indexed condition, and to 2 interventions - of which Perfluorinated Gas/Oxygen Mixture is the first listed.
NCT01640288 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT01640288 about?
NCT01640288 is a clinical study titled "Imaging Regional Lung Defect Severity". The purpose of this study is to develop and evaluate the usefulness of magnetic resonance imaging (MRI) using inert perfluorinated gases mixed with oxygen for regional assessment of pulmonary function. The proposed study seeks to determine regional qualitative and quantitative lung function informat...
What is the current status of trial NCT01640288?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 171 participants. The study started on 2013-01. Estimated completion is 2018-08-10.
What conditions does trial NCT01640288 study?
This clinical trial studies the following conditions: COPD.
What interventions are being tested in trial NCT01640288?
The interventions under investigation include: Perfluorinated Gas/Oxygen Mixture (DRUG), High Resolution CT of the Chest (OTHER).
Who is sponsoring clinical trial NCT01640288?
This trial is sponsored by Hal C Charles, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01640288 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for COPD
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01640288's enrollment target sits among peer trials
171 32nd of 85 higher than 53 of 85 other COPD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COPD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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