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ClinicalTrials.gov 28 recruiting now official registry

COPD clinical trials

28 of 86 indexed COPD trials are currently recruiting.

86 US clinical trials · 28 currently recruiting

COPD is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.

The research picture

COPD has 86 registered US clinical trials, 28 of them open to new participants right now, about 33% of the total.

28
recruiting participants now
33%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
6
top sponsor: VA Office of Research and Development
Phase 16Phase 26Phase 33Phase 48

Active & Recent Trials

86 total, page 2 of 2

COMPLETED 117 participants

Alpha-1 Carrier Genomics Study

Medical University of South Carolina

NCT02810327

COMPLETED 100 participants

Healthy At Home Pilot

University of Massachusetts, Worcester

NCT06000696

COMPLETED Phase 4 89 participants

Effect of Nebulized Bronchodilators on Heart Rate

Fahim Khorfan, MD

NCT01151579

COMPLETED 88 participants

A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).

Centocor

NCT00380796

COMPLETED NA 74 participants

Monitoring Metered Dose Inhalation (MDI) Volume and Timing With a Respimetrix Device in Obstructive Lung Disease.

Pulmonary Critical Care Associates of Baltimore

NCT05495256

COMPLETED 72 participants

Functional Proteomics of Alveolar Macrophages

Ohio State University

NCT00806091

COMPLETED NA 71 participants

At Home Spirometry and Video Module Education for COPD Patients

University of Chicago

NCT03834350

COMPLETED Phase 2 64 participants

A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

Mylan

NCT02109172

COMPLETED Phase 2 58 participants

MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects

Xemed

NCT01833390

COMPLETED NA 52 participants

Pathogenesis and Outcomes of Sleep Disordered Breathing in Chronic Obstructive Pulmonary Disease (COPD)

Johns Hopkins University

NCT01764165

COMPLETED Phase 4 50 participants

Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

Johns Hopkins University

NCT00181207

COMPLETED NA 50 participants

Nurse Coach-Led Early Palliative Care for Older Adults With COPD and Their Care Partners: The Project EPIC Pilot RCT

University of Alabama at Birmingham

NCT05040386

COMPLETED Phase 1 44 participants

Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen

Hal C Charles

NCT01710449

COMPLETED 42 participants

Integrative-omics of the Disordered COPD Small Airway Epithelium

Weill Medical College of Cornell University

NCT02183818

COMPLETED NA 42 participants

Vector Engineering Clinical

Philips Clinical & Medical Affairs Global

NCT04725500

COMPLETED NA 42 participants

Capnography-Assisted Learned Monitored (CALM) Breathing Therapy for COPD

Columbia University

NCT04786184

COMPLETED NA 40 participants

Randomized Controlled Eight-Week Study of the Safety and Efficacy of the Lung Flute

Medical Acoustics

NCT00560105

COMPLETED NA 32 participants

Rehabilitation of Patients With COPD Using Electrical Muscle Stimulation

Yale University

NCT01799330

COMPLETED NA 31 participants

A Phase I Study of iPS Cell Generation From Patients With COPD

Mayo Clinic

NCT01860898

COMPLETED Phase 4 30 participants

Peak Inspiratory Flow and Dry Powder Inhaler Performance in COPD

Pulmonary Research Institute of Southeast Michigan

NCT04606394

COMPLETED Phase 1 30 participants

Effect of Statin Therapy on C-reactive Protein Levels in Patients With Chronic Obstructive Lung Disease (COPD)

VA Loma Linda Health Care System

NCT00655993

COMPLETED NA 30 participants

Evaluation of Muscle Activation Efficiency in Challenging Subjects

Niveus Medical

NCT01811446

COMPLETED NA 27 participants

A Placebo-controlled Trial of Daliresp on Chronic Obstructive Pulmonary Disease (COPD)

University of Alabama at Birmingham

NCT01572948

COMPLETED 21 participants

The Trajectory of Physical Activity Following Pulmonary Rehabilitation

Trinity Health Of New England

NCT02399254

COMPLETED NA 20 participants

Interleukin-5 Receptor Expression in COPD

University of Virginia

NCT03984799

COMPLETED Phase 4 20 participants

Effect of Brovana and Tiotropium in Chronic Obstructive Pulmonary Disease (COPD)

Trinity Health Of New England

NCT00773786

COMPLETED Phase 1 20 participants

Mindfulness Based Stress Reduction in COPD

Mayo Clinic

NCT01058499

COMPLETED Phase 1 17 participants

Real-Time Support for Exercise Persistence in COPD

University of Washington

NCT00373932

COMPLETED Phase 4 15 participants

Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients

Gary L. Pierce

NCT03611699

COMPLETED NA 12 participants

Innovative Pulmonary Rehabilitation Telehealth Program for Improving COPD Patient Outcomes

University of Kansas Medical Center

NCT03489642

COMPLETED NA 12 participants

Use of Dexmedetomidine for Sedation During Flexible Bronchoscopy in Patients With COPD: A Descriptive Study

The Cooper Health System

NCT00401206

COMPLETED NA 12 participants

Respiratory Disorders Non-invasive Monitoring of Work of Breathing in Outpatients

Stanford University

NCT04003415

COMPLETED NA 11 participants

Device-guided Breathing for Shortness of Breath in COPD

Mayo Clinic

NCT01286181

COMPLETED 9 participants

BRAIN, Symptoms, and Physical Activity in COPD

VA Office of Research and Development

NCT04291131

COMPLETED Phase 2 6 participants

Study to Assess the Safety and Tolerability of Incremental Doses of QAB149 in Adults With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD)

Novartis

NCT00129831

COMPLETED NA 6 participants

A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients

Mayo Clinic

NCT03814980

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 6
Phase 3 3
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the COPD Trial Landscape

86 indexed COPD studies · 28 recruiting (33%).

Phase mix: 11 late (III/IV) vs 12 early (I/II).

Top sponsor: VA Office of Research and Development (6 trials), 9 others listed. 36 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for COPD?

PlainTrial tracks 86 US clinical trials for COPD, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for COPD?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.