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COPD clinical trials
28 of 86 indexed COPD trials are currently recruiting.
86 US clinical trials · 28 currently recruiting
COPD is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
The research picture
COPD has 86 registered US clinical trials, 28 of them open to new participants right now, about 33% of the total.
- 28
- recruiting participants now
- 33%
- of trials open to enrollment
- 11
- in Phase 3–4 (later-stage)
- 6
- top sponsor: VA Office of Research and Development
Active & Recent Trials
86 total, page 2 of 2
Alpha-1 Carrier Genomics Study
Medical University of South Carolina
NCT02810327
Healthy At Home Pilot
University of Massachusetts, Worcester
NCT06000696
Effect of Nebulized Bronchodilators on Heart Rate
Fahim Khorfan, MD
NCT01151579
A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
Centocor
NCT00380796
Monitoring Metered Dose Inhalation (MDI) Volume and Timing With a Respimetrix Device in Obstructive Lung Disease.
Pulmonary Critical Care Associates of Baltimore
NCT05495256
Functional Proteomics of Alveolar Macrophages
Ohio State University
NCT00806091
At Home Spirometry and Video Module Education for COPD Patients
University of Chicago
NCT03834350
A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
Mylan
NCT02109172
MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects
Xemed
NCT01833390
Pathogenesis and Outcomes of Sleep Disordered Breathing in Chronic Obstructive Pulmonary Disease (COPD)
Johns Hopkins University
NCT01764165
Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
Johns Hopkins University
NCT00181207
Nurse Coach-Led Early Palliative Care for Older Adults With COPD and Their Care Partners: The Project EPIC Pilot RCT
University of Alabama at Birmingham
NCT05040386
Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen
Hal C Charles
NCT01710449
Integrative-omics of the Disordered COPD Small Airway Epithelium
Weill Medical College of Cornell University
NCT02183818
Vector Engineering Clinical
Philips Clinical & Medical Affairs Global
NCT04725500
Capnography-Assisted Learned Monitored (CALM) Breathing Therapy for COPD
Columbia University
NCT04786184
Randomized Controlled Eight-Week Study of the Safety and Efficacy of the Lung Flute
Medical Acoustics
NCT00560105
Rehabilitation of Patients With COPD Using Electrical Muscle Stimulation
Yale University
NCT01799330
A Phase I Study of iPS Cell Generation From Patients With COPD
Mayo Clinic
NCT01860898
Peak Inspiratory Flow and Dry Powder Inhaler Performance in COPD
Pulmonary Research Institute of Southeast Michigan
NCT04606394
Effect of Statin Therapy on C-reactive Protein Levels in Patients With Chronic Obstructive Lung Disease (COPD)
VA Loma Linda Health Care System
NCT00655993
Evaluation of Muscle Activation Efficiency in Challenging Subjects
Niveus Medical
NCT01811446
A Placebo-controlled Trial of Daliresp on Chronic Obstructive Pulmonary Disease (COPD)
University of Alabama at Birmingham
NCT01572948
The Trajectory of Physical Activity Following Pulmonary Rehabilitation
Trinity Health Of New England
NCT02399254
Interleukin-5 Receptor Expression in COPD
University of Virginia
NCT03984799
Effect of Brovana and Tiotropium in Chronic Obstructive Pulmonary Disease (COPD)
Trinity Health Of New England
NCT00773786
Mindfulness Based Stress Reduction in COPD
Mayo Clinic
NCT01058499
Real-Time Support for Exercise Persistence in COPD
University of Washington
NCT00373932
Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients
Gary L. Pierce
NCT03611699
Innovative Pulmonary Rehabilitation Telehealth Program for Improving COPD Patient Outcomes
University of Kansas Medical Center
NCT03489642
Use of Dexmedetomidine for Sedation During Flexible Bronchoscopy in Patients With COPD: A Descriptive Study
The Cooper Health System
NCT00401206
Respiratory Disorders Non-invasive Monitoring of Work of Breathing in Outpatients
Stanford University
NCT04003415
Device-guided Breathing for Shortness of Breath in COPD
Mayo Clinic
NCT01286181
BRAIN, Symptoms, and Physical Activity in COPD
VA Office of Research and Development
NCT04291131
Study to Assess the Safety and Tolerability of Incremental Doses of QAB149 in Adults With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD)
Novartis
NCT00129831
A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients
Mayo Clinic
NCT03814980
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 6 |
| Phase 3 | 3 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the COPD Trial Landscape
86 indexed COPD studies · 28 recruiting (33%).
Phase mix: 11 late (III/IV) vs 12 early (I/II).
Top sponsor: VA Office of Research and Development (6 trials), 9 others listed. 36 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for COPD?
PlainTrial tracks 86 US clinical trials for COPD, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for COPD?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.