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NCT02538744 · ClinicalTrials.gov registry record · Phase 1

Complementary Combination Therapy for Cocaine Dependence

A Phase 1 study of Cocaine Dependence, sponsored by Baylor College of Medicine.

Completed
Registry status
Phase 1
Development phase
45
Enrollment target
1
Study location

NCT02538744 is a Phase 1 study of Cocaine Dependence that has completed, run by Baylor College of Medicine. The registered enrollment target is 45 participants, below the 297-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT02538744, a Phase 1 study of Cocaine Dependence, has completed, sponsored by Baylor College of Medicine.

COMPLETED
Registry status
Phase 1
Development phase
45 participants
Enrollment target
1
Study location

Study Summary

The investigators will assess the impact of treatment with doxazosin and modafinil, alone and in combination, on the subjective and reinforcing effects of cocaine in non-treatment-seeking, cocaine-dependent volunteers. The investigators will use a hybrid design in which participants will be randomized into two groups: placebo and doxazosin 8 mg/d. They will remain in their assigned group for the duration of the study. After titrating doxazosin to the target dose, study procedures will be completed three times, once during treatment with each dose of modafinil (0, 200, and 300 mg/d), in pseudo-random order such that 200 mg precedes 300 mg).

Conditions Studied

Cocaine Dependence

Interventions

  • DRUG Placebo
  • DRUG Doxazosin
  • DRUG Modafinil
  • DRUG cocaine

Study Locations (1)

Texas

  • Michael Debakey VA Medical Center - Houston

Trial Details

FieldValue
Enrollment Target 45 participants
Start Date 2015-08
Est. Completion 2018-08-21
Phase Phase 1

Sponsor

Baylor College of Medicine

616 total trials

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What the Registry Record Tells You About NCT02538744

The ClinicalTrials.gov registry entry for NCT02538744 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 297-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (85% lower). The listed sponsor is Baylor College of Medicine, which has 616 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Cocaine Dependence appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.

NCT02538744 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT02538744 about?

NCT02538744 is a clinical study titled "Complementary Combination Therapy for Cocaine Dependence". The investigators will assess the impact of treatment with doxazosin and modafinil, alone and in combination, on the subjective and reinforcing effects of cocaine in non-treatment-seeking, cocaine-dependent volunteers. The investigators will use a hybrid design in which participants will be randomiz...

What is the current status of trial NCT02538744?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 45 participants. The study started on 2015-08. Estimated completion is 2018-08-21.

What conditions does trial NCT02538744 study?

This clinical trial studies the following conditions: Cocaine Dependence.

What interventions are being tested in trial NCT02538744?

The interventions under investigation include: Placebo (DRUG), Doxazosin (DRUG), Modafinil (DRUG), cocaine (DRUG).

Who is sponsoring clinical trial NCT02538744?

This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT02538744 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.