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ClinicalTrials.gov 10 recruiting now official registry

Human Papilloma Virus clinical trials

10 of 27 indexed Human Papilloma Virus trials are currently recruiting.

27 US clinical trials · 10 currently recruiting

Human Papilloma Virus is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is UNC Lineberger Comprehensive Cancer Center, running 2 of these trials.

The research picture

Human Papilloma Virus has 27 registered US clinical trials, 10 of them open to new participants right now, about 37% of the total.

10
recruiting participants now
37%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: UNC Lineberger Comprehensive Cancer Center
Phase 16Phase 25Phase 41

Active & Recent Trials

27 total, page 1 of 1

RECRUITING 5,000 participants

Prevention of Cervical Cancer Using the Genotyping Screening and Same-day Self-sampling

Atila Biosystems

NCT07232355

RECRUITING NA 1,000 participants

Educate and Improve Underserved Populations' Uptake and Completion of the HPV Vaccine

University of Colorado, Denver

NCT04611022

RECRUITING 1,000 participants

Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma

Stanford University

NCT05880797

RECRUITING NA 365 participants

Advancing HPV Vaccination Among HIV Positive Adults: The CHAMPS Study

Emory University

NCT05065840

RECRUITING Phase 2 121 participants

A Study of Reduced Radiation Therapy and Standard-of-Care Chemotherapy in People With HPV-Positive Throat Cancer

Memorial Sloan Kettering Cancer Center

NCT05491512

RECRUITING Phase 2 120 participants

Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV

University of Maryland, Baltimore

NCT06624839

RECRUITING NA 120 participants

PopSci CHW4CervixHealth

Thomas Jefferson University

NCT07336134

RECRUITING Phase 1 98 participants

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

University of Chicago

NCT05108870

RECRUITING Phase 1 30 participants

Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery

Ryan Carey

NCT06747390

RECRUITING Early Phase 1 20 participants

Merck IIT: RRP Pembro and Lenvatinib

Yale University

NCT04645602

ACTIVE NOT RECRUITING 1,500 participants

Men and Women Offering Understanding of Throat HPV

Johns Hopkins University

NCT03644563

ACTIVE NOT RECRUITING Phase 4 767 participants

GARDASIL 9: 3 Dose vs. 2 Dose With Delayed 3rd Dose

The University of Texas Medical Branch, Galveston

NCT03943875

ACTIVE NOT RECRUITING NA 235 participants

Development of a Self-collection Device for Cervical Cancer Screening

Teal Health

NCT05669911

ACTIVE NOT RECRUITING Early Phase 1 155 participants

Immunogenicity of the 9vHPV Vaccination 2-dose Regimen Among Children 4 to 8 Years Old

Boston Medical Center

NCT05329961

ACTIVE NOT RECRUITING NA 150 participants

TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck

Abramson Cancer Center at Penn Medicine

NCT03729518

ACTIVE NOT RECRUITING NA 34 participants

Impact of Financial Incentives

UNC Lineberger Comprehensive Cancer Center

NCT05744960

ACTIVE NOT RECRUITING NA 28 participants

Impact of Standing Orders Optimization

UNC Lineberger Comprehensive Cancer Center

NCT05742386

COMPLETED NA 3,812 participants

Text Reminders to Immunize in a Managed Care Organization

University of Rochester

NCT01806714

COMPLETED NA 1,043 participants

HPV Message Testing and Social Media Campaign

Dartmouth-Hitchcock Medical Center

NCT03747302

COMPLETED NA 225 participants

High and Low Resource Interventions to Promote HPV Vaccines

Children's Mercy Hospital Kansas City

NCT03824093

COMPLETED NA 168 participants

PreTeenVax Evaluation

Emory University

NCT03186430

COMPLETED NA 112 participants

The Sinai Robotic Surgery Trial in HPV Positive Oropharyngeal Squamous Cell Carcinoma (SCCA) (SIRS TRIAL)

Icahn School of Medicine at Mount Sinai

NCT02072148

COMPLETED Phase 2 39 participants

Candin Safety & Efficacy Study for the Treatment of Warts

Nielsen BioSciences

NCT01757392

COMPLETED Phase 1 35 participants

Safety and Efficacy of MEDI0457 and Durvalumab in Participants With Human Papilloma Virus (HPV) Associated Recurrent/Metastatic Head and Neck Cancer

MedImmune

NCT03162224

COMPLETED Phase 2 35 participants

De-Escalation Therapy for Human Papillomavirus Negative Disease

University of Chicago

NCT03944915

COMPLETED Phase 2 13 participants

Avelumab for People With Recurrent Respiratory Papillomatosis

National Cancer Institute (NCI)

NCT02859454

COMPLETED Phase 1 2 participants

Intralesional HPV Vaccine for Condylomata

University of California, San Francisco

NCT05087849

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 5
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Human Papilloma Virus Trial Landscape

27 indexed Human Papilloma Virus studies · 10 recruiting (37%).

Phase mix: 1 late (III/IV) vs 11 early (I/II).

Top sponsor: UNC Lineberger Comprehensive Cancer Center (2 trials), 9 others listed. 27 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Human Papilloma Virus?

PlainTrial tracks 27 US clinical trials for Human Papilloma Virus, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Human Papilloma Virus?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.