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NCT00685178 · ClinicalTrials.gov registry record · Phase 2
Clinical Trial of Topiramate for Cocaine Addiction
A Phase 2 study of Cocaine Dependence, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Phase 2
- Development phase
- 250
- Enrollment target
- 1
- Study location
NCT00685178: Completed Phase 2 study of Cocaine Dependence, sponsored by Johns Hopkins University.
NCT00685178 is a Phase 2 study of Cocaine Dependence that has completed, run by Johns Hopkins University. The registered enrollment target is 250 participants, below the 292-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (14% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00685178, a Phase 2 study of Cocaine Dependence, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 250 participants
- Enrollment target
- 1
- Study location
Study Summary
This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment. The study aims to answer whether topiramate 1. is safe and acceptable to methadone patients 2. reduces cocaine use 3. helps with collateral problems such as alcohol abuse, tobacco dependence, anxiety, PTSD and/or pain symptoms. The study will also evaluate topiramate effect on neuro-cognitive performance.
Primary Outcome
Percentage of cocaine positive urine samples as measured by Preston new use rule (50% reduction in cocaine metabolites from previous urine)
Conditions Studied
Interventions
- DRUG topiramate
- BEHAVIORAL Contingency Reinforcement
- DRUG placebo + NonCR
Study Locations (1)
Maryland
- Behavioral Pharmacology Research Unit - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2007-02 |
| Est. Completion | 2011-09 |
| Phase | Phase 2 |
What the finished NCT00685178 record still lists
NCT00685178 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 292-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (14% lower).
The record links to 1 condition, with Cocaine Dependence appearing as the primary indexed condition, and to 3 interventions - of which topiramate is the first listed.
NCT00685178 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00685178 about?
NCT00685178 is a clinical study titled "Clinical Trial of Topiramate for Cocaine Addiction". This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment. The study aims to answer whether topiramate 1. is safe and acceptable to methadone patients 2. reduce...
What is the current status of trial NCT00685178?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 250 participants. The study started on 2007-02. Estimated completion is 2011-09.
What conditions does trial NCT00685178 study?
This clinical trial studies the following conditions: Cocaine Dependence.
What interventions are being tested in trial NCT00685178?
The interventions under investigation include: topiramate (DRUG), Contingency Reinforcement (BEHAVIORAL), placebo + NonCR (DRUG).
Who is sponsoring clinical trial NCT00685178?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00685178 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00685178's enrollment target sits among peer trials
250 3rd of 38 higher than 36 of 38 other Cocaine Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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