Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03527485 · ClinicalTrials.gov registry record · NA
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
A NA study of Cocaine Dependence and Opiate Dependence, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 41
- Enrollment target
- 1
- Study location
NCT03527485 is a NA study of Cocaine Dependence and Opiate Dependence that has completed, run by Yale University. The registered enrollment target is 41 participants, below the 297-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state.
The verdict
NCT03527485, a NA study of Cocaine Dependence and Opiate Dependence, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to measure synaptic density in the brains (including in ventral striatum \[VS\] and medial prefrontal cortex \[mPFC\]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to healthy control (HC) subjects using 11C-UCB-J PET. Subjects will undergo a single 11C-UCB-J (also known as 11C-APP311) PET scan. This would be the very first to image synaptic density in human cocaine and opiate users, thereby testing whether altered synaptic density in the rodent brain is recapitulated in CUD and OUD humans. If confirmed, the current study would provide compelling clinical-translational support for an important pathophysiological mechanism of addiction - aberrant structural synaptic plasticity. As such, the current study has considerable potential for advancing the neurobiological understanding of human cocaine and opiate addiction.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST 11UCB-J PET Scan
Study Locations (1)
Connecticut
- CT Mental Health Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2019-01-01 |
| Est. Completion | 2023-03-28 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03527485
The ClinicalTrials.gov registry entry for NCT03527485 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 41 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 297-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (86% lower). The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Cocaine Dependence appearing as the primary indexed condition, and to 1 intervention - of which 11UCB-J PET Scan is the first listed.
NCT03527485 reports 1 study location spanning 1 distinct geographic area - top geographies include Connecticut.
Frequently Asked Questions
What is clinical trial NCT03527485 about?
NCT03527485 is a clinical study titled "Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET". This study aims to measure synaptic density in the brains (including in ventral striatum \[VS\] and medial prefrontal cortex \[mPFC\]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to healthy control (HC) subjects using 11C-UCB-J PET. Subjects will un...
What is the current status of trial NCT03527485?
This trial is currently completed. It is a NA study. The enrollment target is 41 participants. The study started on 2019-01-01. Estimated completion is 2023-03-28.
What conditions does trial NCT03527485 study?
This clinical trial studies the following conditions: Cocaine Dependence, Opiate Dependence.
What interventions are being tested in trial NCT03527485?
The interventions under investigation include: 11UCB-J PET Scan (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT03527485?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03527485 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder
RECRUITING · NA
-
Vouchers vs. Prizes for Cocaine-Dependent Methadone Patients - 2
COMPLETED · NA
-
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
COMPLETED · NA
-
Exercise as a Behavioral Treatment for Cocaine Dependence
COMPLETED · NA
-
Modafinil, Sleep, and Cognition in Cocaine Dependence
COMPLETED · NA
-
Effectiveness of Extended Treatments for Drug Dependence
COMPLETED · NA
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.