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NCT02141620 · ClinicalTrials.gov registry record · Early Phase 1
n-Acetylcysteine and Cocaine
A Early Phase 1 study of Cocaine Dependence and Cocaine Abuse, sponsored by University of Kentucky.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT02141620: Completed Early Phase 1 study of Cocaine Dependence and Cocaine Abuse, sponsored by University of Kentucky.
NCT02141620 is a Early Phase 1 study of Cocaine Dependence and Cocaine Abuse that has completed, run by University of Kentucky. The registered enrollment target is 15 participants, below the 298-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02141620, a Early Phase 1 study of Cocaine Dependence and Cocaine Abuse, has completed, sponsored by University of Kentucky.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and n-acetylcysteine.
Primary Outcome
The reinforcing effects of cocaine were determined using a modified progressive ratio procedure (Stoops et al., 2010) in which subjects made 6 choices between available each available cocaine dose and money (US$0.25). Reinforcing effects are measured for each cocaine dose during both buspirone and placebo maintenance.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Cocaine
- DRUG n-Acetylcysteine
Study Locations (1)
Kentucky
- University of Kentucky Laboratory of Human Behavioral Pharmacology - Lexington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2014-05 |
| Est. Completion | 2016-04 |
| Phase | Early Phase 1 |
What the finished NCT02141620 record still lists
NCT02141620 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 298-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (95% lower).
The record links to 2 conditions, with Cocaine Dependence appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT02141620 reports a single indexed study location in Kentucky.
Frequently Asked Questions
What is clinical trial NCT02141620 about?
NCT02141620 is a clinical study titled "n-Acetylcysteine and Cocaine". This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maint...
What is the current status of trial NCT02141620?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 15 participants. The study started on 2014-05. Estimated completion is 2016-04.
What conditions does trial NCT02141620 study?
This clinical trial studies the following conditions: Cocaine Dependence, Cocaine Abuse.
What interventions are being tested in trial NCT02141620?
The interventions under investigation include: Placebo (DRUG), Cocaine (DRUG), n-Acetylcysteine (DRUG).
Who is sponsoring clinical trial NCT02141620?
This trial is sponsored by University of Kentucky, which has 54 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02141620 being conducted?
This trial has 1 study location across Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02141620's enrollment target sits among peer trials
15 37th of 38 higher than 2 of 38 other Cocaine Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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