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NCT00566969 · ClinicalTrials.gov registry record · NA
Cocaine Withdrawal and Pharmacotherapy Response
A NA study of Cocaine Dependence and Opiate Dependence, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 106
- Enrollment target
- 1
- Study location
NCT00566969: Completed NA study of Cocaine Dependence and Opiate Dependence, sponsored by Yale University.
NCT00566969 is a NA study of Cocaine Dependence and Opiate Dependence that has completed, run by Yale University. The registered enrollment target is 106 participants, below the 296-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00566969, a NA study of Cocaine Dependence and Opiate Dependence, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 106 participants
- Enrollment target
- 1
- Study location
Study Summary
A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day) in methadone stabilized patients. The design will have two phases: 1) a four-week "treatment " phase; and 2) a 4 week " taper and detoxification or transfer" phase. Subjects will be cocaine users who are on stable doses of methadone (60 to 140 mg/day). Carvedilol dose will be increased from 12.5mg/day to the target dose of either 25 or 50 mg/day as tolerated. At the end of the treatment-phase, subjects will undergo detoxification from methadone over a 2 to 4-week period based on an individual's needs, and they will concurrently be tapered off carvedilol.
Primary Outcome
Percent Self reported days of abstinence from any cocaine use during the 11 week trial.
Conditions Studied
Interventions
- DRUG sugar pill
- DRUG Carvedilol 25 mg
- DRUG Carvedilol 50 mg
Study Locations (1)
Connecticut
- Veterans Hospital - West Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 106 participants |
| Start Date | 2007-09 |
| Est. Completion | 2013-01 |
| Phase | NA |
What the finished NCT00566969 record still lists
NCT00566969 is an interventional study that assigns participants to a tested intervention. The registered 106 participants enrollment target is mid-sized for trials with a published cap, below the 296-participant average among 38 other Cocaine Dependence trials with a reported enrollment target (64% lower).
The record links to 2 conditions, with Cocaine Dependence appearing as the primary indexed condition, and to 3 interventions - of which sugar pill is the first listed.
NCT00566969 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT00566969 about?
NCT00566969 is a clinical study titled "Cocaine Withdrawal and Pharmacotherapy Response". A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day) in methadone stabilized patients. The design will have two phases: 1) ...
What is the current status of trial NCT00566969?
This trial is currently completed. It is a NA study. The enrollment target is 106 participants. The study started on 2007-09. Estimated completion is 2013-01.
What conditions does trial NCT00566969 study?
This clinical trial studies the following conditions: Cocaine Dependence, Opiate Dependence.
What interventions are being tested in trial NCT00566969?
The interventions under investigation include: sugar pill (DRUG), Carvedilol 25 mg (DRUG), Carvedilol 50 mg (DRUG).
Who is sponsoring clinical trial NCT00566969?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00566969 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00566969's enrollment target sits among peer trials
106 20th of 38 higher than 19 of 38 other Cocaine Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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