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RECRUITING Phase 3

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

NCT07190222 · View on ClinicalTrials.gov ↗

Study Summary

This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COPD) characterized by an eosinophilic phenotype. Participation to the study consists of 3 periods: * Screening period of up to 4 weeks * Randomized intervention period of approximately 48 weeks * Follow-up period: Approximately 8 weeks The study duration will be up to 60 weeks.

Interventions

  • DRUG Placebo
  • DRUG Lunsekimig

Study Locations (20)

Florida

  • Hillcrest Medical Research- Site Number : 8400082 — DeLand
  • Finlay Medical Research - Greenacres- Site Number : 8400107 — Greenacres City
  • Direct Helpers Research Center- Site Number : 8400057 — Hialeah
  • Pulmonary Specialists of the Palm Beaches- Site Number : 8400017 — Loxahatchee Groves
  • DL Research Solutions- Site Number : 8400140 — Miami
  • Phoenix Medical Research - Miami - 24th Street- Site Number : 8400027 — Miami
  • Professional Research Center- Site Number : 8400046 — Miami
  • Research Institute of South Florida- Site Number : 8400028 — Miami
  • Innovations Biotech- Site Number : 8400019 — Miami
  • Heuer M.D. Research- Site Number : 8400018 — Orlando
  • Florida Institute for Clinical Research- Site Number : 8400001 — Orlando
  • Avanza Medical Research Center- Site Number : 8400015 — Pensacola
  • Hull and Hull Medical Specialists- Site Number : 8400002 — Plantation

California

  • Ark Clinical Research- Site Number : 8400113 — Long Beach
  • Alliance Clinical - West Hills- Site Number : 8400067 — Los Angeles
  • California Medical Research Associates - Northridge- Site Number : 8400089 — Northridge

Colorado

  • Alpine Clinical Research Center - Boulder - 47th Street- Site Number : 8400005 — Boulder
  • Critical Care Pulmonary & Sleep Associates- Site Number : 8400081 — Lakewood

Arizona

  • Tucson Clinical Research Institute- Site Number : 8400006 — Tucson

Georgia

  • Appalachian Clinical Research- Site Number : 8400060 — Adairsville

Trial Details

FieldValue
Enrollment Target 942 participants
Start Date 2025-09-17
Est. Completion 2030-01-22
Phase Phase 3

Sponsor

Sanofi

275 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07190222

The ClinicalTrials.gov registry entry for NCT07190222 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 942 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sanofi, which has 275 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Chronic Obstructive Pulmonary Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07190222 reports 20 study locations spanning 5 distinct geographic areas — top geographies include Florida, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07190222 about?

NCT07190222 is a clinical study titled "Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype". This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COPD...

What is the current status of trial NCT07190222?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 942 participants. The study started on 2025-09-17. Estimated completion is 2030-01-22.

What conditions does trial NCT07190222 study?

This clinical trial studies the following conditions: Chronic Obstructive Pulmonary Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07190222?

The interventions under investigation include: Placebo (DRUG), Lunsekimig (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07190222?

This trial is sponsored by Sanofi, which has 275 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07190222 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial