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ClinicalTrials.gov 29 recruiting now official registry

Chronic Obstructive Pulmonary Disease clinical trials

29 of 87 indexed Chronic Obstructive Pulmonary Disease trials are currently recruiting.

87 US clinical trials · 29 currently recruiting

Chronic Obstructive Pulmonary Disease is the subject of 87 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most active sponsor is Sanofi, running 6 of these trials.

The research picture

Chronic Obstructive Pulmonary Disease has 87 registered US clinical trials, 29 of them open to new participants right now, about 33% of the total.

29
recruiting participants now
33%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
6
top sponsor: Sanofi
Phase 19Phase 218Phase 315Phase 44

Active & Recent Trials

87 total, page 2 of 2

COMPLETED Phase 3 440 participants

NVA237 Versus Placebo 12-week Efficacy Study

Novartis Pharmaceuticals

NCT01709864

COMPLETED Phase 3 357 participants

Efficacy and Safety Study of QVA149 in COPD Patients

Novartis Pharmaceuticals

NCT02487446

COMPLETED 336 participants

Audio Data Collection for Identification and Classification of Coughing

HealthMode

NCT04326309

COMPLETED 330 participants

HIV-related Accelerated Aging of the Airway Epithelium

Weill Medical College of Cornell University

NCT01974219

COMPLETED Phase 2 237 participants

PT003 MDI Cardiovascular Safety Study

Pearl Therapeutics

NCT01349803

COMPLETED NA 200 participants

Anxiety and COPD Evaluation

NYU Langone Health

NCT02740465

COMPLETED NA 182 participants

Active for Life: Chronic Obstructive Pulmonary Disease

University of Michigan

NCT03201198

COMPLETED NA 172 participants

Remote Physician Care for Home Hospital Patients

Brigham and Women's Hospital

NCT04080570

COMPLETED NA 142 participants

Video vs. TTG Respiratory Inhaler Technique Assessment and InstructioN (V-TRaIN)

University of Chicago

NCT02611531

COMPLETED NA 139 participants

Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA

Peter Lindenauer, MD

NCT05562037

COMPLETED Phase 2 118 participants

Study to Evaluate the Efficacy, Safety and Pharmacokinetics of PT001, PT003, and PT005 Following Chronic Dosing (7 Days) in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)

Pearl Therapeutics

NCT01085045

COMPLETED 100 participants

Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease

University of North Carolina, Chapel Hill

NCT00903955

COMPLETED NA 97 participants

Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions

Treatment Research Institute

NCT02059005

COMPLETED NA 91 participants

Vibratory PEP Device and Hospital Length of Stay for Acute Exacerbation of COPD

New York Presbyterian Brooklyn Methodist Hospital

NCT03094806

COMPLETED 75 participants

Vibration Response Imaging in Chronic Obstructive Pulmonary Disease and Asthma

Deep Breeze

NCT00542282

COMPLETED Phase 4 70 participants

Nebulized Hypertonic Saline for Inpatient Use in COPD

OhioHealth

NCT02266875

COMPLETED Phase 3 68 participants

A Crossover Study to Determine the 24 Hour Lung Function Profile of Indacaterol in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

Novartis Pharmaceuticals

NCT00622635

COMPLETED Phase 2 64 participants

A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

Mylan

NCT02109172

COMPLETED Phase 2 57 participants

Confirmatory Dose Finding Study of 2 Dosages of CHF 4226 pMDI (Carmoterol) in Patients With COPD

Chiesi Farmaceutici S.p.A.

NCT00640484

COMPLETED NA 56 participants

COPD Assessment and Management Bundle Versus Usual Care

University of Illinois at Chicago

NCT01833026

COMPLETED NA 52 participants

Indoor Air Quality and Respiratory Symptoms in Former Smokers

Intermountain Health Care

NCT02956213

COMPLETED Phase 2 46 participants

A Phase IIb Study of Glycopyrrolate Inhalation Solution Over 1 Week in Subjects With COPD

Verona Pharma

NCT06545500

COMPLETED Phase 2 33 participants

A Phase II Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Single Inhaled Doses of Ensifentrine-glycopyrrolate Fixed Dose Combination, Ensifentrine, and Glycopyrrolate in Subjects With Chronic Obstructive Pulmonary Disease

Verona Pharma

NCT07132983

COMPLETED 33 participants

Modifying Exercise for the COPD Patient

Angela N Fellner PhD CCRP

NCT02143206

COMPLETED Phase 1 26 participants

Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease

Kimera Society

NCT02216630

COMPLETED Phase 2 25 participants

A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00094562

COMPLETED Phase 2 24 participants

Inhaled Iloprost, Dynamic Hyperinflation, and Oxidative Stress in COPD Patients

Louisiana State University Health Sciences Center in New Orleans

NCT01941225

COMPLETED Phase 1 20 participants

Mindfulness Based Stress Reduction in COPD

Mayo Clinic

NCT01058499

COMPLETED NA 20 participants

Efficacy of Inhaling Bronchodilator Medications in Chronic Obstructive Pulmonary Disease

Dartmouth-Hitchcock Medical Center

NCT01391559

COMPLETED Phase 2 17 participants

Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies

University of Alabama at Birmingham

NCT03244059

COMPLETED NA 15 participants

Effects of the Breathe Technologies Ventilation System in Subjects With Chronic Obstructive Pulmonary Disease

Breathe Technologies

NCT01372462

COMPLETED Phase 1 15 participants

Mesenchymal Stem Cells in the Treatment of Subjects With Advance Chronic Obstructive Pulmonary Disease (COPD)

Mayo Clinic

NCT04047810

COMPLETED Phase 4 14 participants

The Effect of STIOLTO™ RESPIMAT® on Fatigue in Chronic Obstructive Pulmonary Disease

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

NCT02845752

COMPLETED NA 12 participants

Hydrolyzed Casein and Whey Protein Supplementation and the Addition of Leucine to Induce Protein Anabolism in Malnourished COPD Patients

Texas A&M University

NCT01154400

COMPLETED Phase 1 11 participants

Safety, Tolerability, and Pharmacokinetics of Andecaliximab in Adults With Chronic Obstructive Pulmonary Disease (COPD)

Gilead Sciences

NCT02077465

COMPLETED NA 8 participants

Uphill Walking as Exercise for COPD Patients

VA Office of Research and Development

NCT04026529

COMPLETED NA 7 participants

Rural Home Hospital: Proof of Concept

Brigham and Women's Hospital

NCT04531280

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Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 18
Phase 3 15
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Obstructive Pulmonary Disease Trial Landscape

87 indexed Chronic Obstructive Pulmonary Disease studies · 29 recruiting (33%).

Phase mix: 19 late (III/IV) vs 27 early (I/II).

Top sponsor: Sanofi (6 trials), 9 others listed. 37 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Obstructive Pulmonary Disease?

PlainTrial tracks 87 US clinical trials for Chronic Obstructive Pulmonary Disease, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Obstructive Pulmonary Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.