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NCT04660929 · ClinicalTrials.gov registry record · Phase 1
CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors
A Phase 1 study of Breast Cancer and Cancer, sponsored by Carisma Therapeutics.
- Active
- Registry status
- Phase 1
- Development phase
- 48
- Enrollment target
- 7
- Study locations
NCT04660929 is a Phase 1 study of Breast Cancer and Cancer that is active but no longer recruiting, run by Carisma Therapeutics. The registered enrollment target is 48 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (98% lower). The trial reports 7 study locations across 7 states.
The verdict
NCT04660929, a Phase 1 study of Breast Cancer and Cancer, is active but no longer recruiting, sponsored by Carisma Therapeutics.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 48 participants
- Enrollment target
- 7
- Study locations
Study Summary
Phase 1, first-in-human, open label study of CAR macrophages in HER2 overexpressing solid tumors.
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
- BIOLOGICAL CT-0508
Study Locations (7)
California
- City of Hope National Medical Center - Duarte
North Carolina
- UNC Lineberger Comprehensive Cancer Center - Chapel Hill
Oregon
- OHSU Knight Cancer Institute - Portland
Pennsylvania
- Abramson Cancer Center - Philadelphia
Tennessee
- Tennessee Oncology / Sarah Cannon Research Institute - Nashville
Texas
- M D Anderson Cancer Center - Houston
Washington
- Fred Hutchinson Cancer Center - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2021-02-02 |
| Est. Completion | 2024-12-31 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04660929
The ClinicalTrials.gov registry entry for NCT04660929 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (98% lower). The listed sponsor is Carisma Therapeutics, which has 2 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT04660929 reports 7 study locations spanning 7 distinct geographic areas - top geographies include California, North Carolina, Oregon.
Frequently Asked Questions
What is clinical trial NCT04660929 about?
NCT04660929 is a clinical study titled "CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors". Phase 1, first-in-human, open label study of CAR macrophages in HER2 overexpressing solid tumors.
What is the current status of trial NCT04660929?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 48 participants. The study started on 2021-02-02. Estimated completion is 2024-12-31.
What conditions does trial NCT04660929 study?
This clinical trial studies the following conditions: Breast Cancer, Cancer, Bladder Cancer, Biliary Tract Cancer, Carcinoma, Hepatocellular.
What interventions are being tested in trial NCT04660929?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL), CT-0508 (BIOLOGICAL).
Who is sponsoring clinical trial NCT04660929?
This trial is sponsored by Carisma Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04660929 being conducted?
This trial has 7 study locations across California, North Carolina, Oregon, Pennsylvania, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.