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NCT04289779 · ClinicalTrials.gov registry record · Phase 2
Study of CAbozantinib in Combination with AtezolizumaB for Muscle-Invasive BladdEr Cancer
A Phase 2 study of Bladder Cancer, sponsored by Deepak Kilari.
- Active
- Registry status
- Phase 2
- Development phase
- 46
- Enrollment target
- 6
- Study locations
NCT04289779 is a Phase 2 study of Bladder Cancer that is active but no longer recruiting, run by Deepak Kilari. The registered enrollment target is 46 participants, below the 12,753-participant average among 175 other Bladder Cancer trials with a reported enrollment target (100% lower). The trial reports 6 study locations across 6 states.
The verdict
NCT04289779, a Phase 2 study of Bladder Cancer, is active but no longer recruiting, sponsored by Deepak Kilari.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 46 participants
- Enrollment target
- 6
- Study locations
Study Summary
This is an open-label phase II study assessing the activity of cabozantinib combined with atezolizumab in patients with resectable muscle-invasive urothelial carcinoma who are ineligible for cisplatin-based therapy or decline cisplatin-based therapy. Each cycle equals 21 days. The dose of atezolizumab is 1200 mg IV flat dose every 3 weeks (Day 1) plus cabozantinib 40 mg orally daily (Day 1 through Day 21). Patients will receive three cycles of treatment prior to cystectomy unless they discontinue treatment for unacceptable toxicity or progressive disease by RECIST v1.1 or withdraw consent.
Conditions Studied
Interventions
- DRUG Atezolizumab
- DRUG Cabozantinib
- PROCEDURE Cystectomy
Study Locations (6)
Missouri
- Washington University School of Medicine - St Louis
New Jersey
- John Theurer Cancer Center - Hackensack
New York
- University of Rochester Medical Center - Rochester
Tennessee
- Vanderbilt-Ingram Cancer Center - Nashville
Virginia
- Virginia Commonwealth University - Richmond
Wisconsin
- Froedtert and The Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2020-05-21 |
| Est. Completion | 2025-12 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04289779
The ClinicalTrials.gov registry entry for NCT04289779 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 46 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 12,753-participant average among 175 other Bladder Cancer trials with a reported enrollment target (100% lower). The listed sponsor is Deepak Kilari, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Bladder Cancer appearing as the primary indexed condition, and to 3 interventions - of which Atezolizumab is the first listed.
NCT04289779 reports 6 study locations spanning 6 distinct geographic areas - top geographies include Missouri, New Jersey, New York.
Frequently Asked Questions
What is clinical trial NCT04289779 about?
NCT04289779 is a clinical study titled "Study of CAbozantinib in Combination with AtezolizumaB for Muscle-Invasive BladdEr Cancer". This is an open-label phase II study assessing the activity of cabozantinib combined with atezolizumab in patients with resectable muscle-invasive urothelial carcinoma who are ineligible for cisplatin-based therapy or decline cisplatin-based therapy. Each cycle equals 21 days. The dose of atezolizum...
What is the current status of trial NCT04289779?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 46 participants. The study started on 2020-05-21. Estimated completion is 2025-12.
What conditions does trial NCT04289779 study?
This clinical trial studies the following conditions: Bladder Cancer.
What interventions are being tested in trial NCT04289779?
The interventions under investigation include: Atezolizumab (DRUG), Cabozantinib (DRUG), Cystectomy (PROCEDURE).
Who is sponsoring clinical trial NCT04289779?
This trial is sponsored by Deepak Kilari, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04289779 being conducted?
This trial has 6 study locations across Missouri, New Jersey, New York, Tennessee, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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