Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05004987 · ClinicalTrials.gov registry record · Phase 4
Aβ Dynamics in LLMD
A Phase 4 study of Alzheimer Disease and Major Depressive Disorder, sponsored by NYU Langone Health.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 60
- Enrollment target
- 2
- Study locations
NCT05004987: Recruiting Phase 4 study of Alzheimer Disease and Major Depressive Disorder, sponsored by NYU Langone Health.
NCT05004987 is a Phase 4 study of Alzheimer Disease and Major Depressive Disorder that is actively recruiting participants, run by NYU Langone Health. The registered enrollment target is 60 participants, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (98% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05004987, a Phase 4 study of Alzheimer Disease and Major Depressive Disorder, is actively recruiting participants, sponsored by NYU Langone Health.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 60 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study will examine the biological factors that may modulate the relationship between depression and the development of Alzheimer's disease (AD). Since the direction of causation between depression and the biological factors associated with AD is unknown, the only way to understand cause and associated risk is to treat the depressive symptoms and examine the effects on AD biomarkers. The study involves an FDA-approved treatment for major depressive disorder. It will compare the SSRI antidepressant escitalopram with placebo. The hypothesis is that a reduction in depressive symptoms will be associated with a normalization of CSF AD biomarkers as well as peripheral inflammatory markers. This research would contribute to fundamental knowledge about potentially modifiable risks of Alzheimer's disease (AD).
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Escitalopram Oxalate
Study Locations (2)
New York
- NYU Langone Health - New York
- Nathan S. Kline Institute for Psychiatric Research - Orangeburg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2022-02-04 |
| Est. Completion | 2027-01-29 |
| Phase | Phase 4 |
What NCT05004987 shows while recruiting
NCT05004987 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05004987 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05004987 about?
NCT05004987 is a clinical study titled "Aβ Dynamics in LLMD". This study will examine the biological factors that may modulate the relationship between depression and the development of Alzheimer's disease (AD). Since the direction of causation between depression and the biological factors associated with AD is unknown, the only way to understand cause and ass...
What is the current status of trial NCT05004987?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 60 participants. The study started on 2022-02-04. Estimated completion is 2027-01-29.
What conditions does trial NCT05004987 study?
This clinical trial studies the following conditions: Alzheimer Disease, Major Depressive Disorder.
What interventions are being tested in trial NCT05004987?
The interventions under investigation include: Placebo (DRUG), Escitalopram Oxalate (DRUG).
Who is sponsoring clinical trial NCT05004987?
This trial is sponsored by NYU Langone Health, which has 1,164 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05004987 being conducted?
This trial has 2 study locations across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05004987's enrollment target sits among peer trials
60 187th of 306 higher than 108 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease
RECRUITING · Phase 4
-
Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease
RECRUITING · Phase 4
-
Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease
ACTIVE NOT RECRUITING · Phase 4
-
The Depression in Alzheimer's Disease Study (DIADS)
COMPLETED · Phase 4
-
Antipsychotic Discontinuation in Alzheimer's Disease
COMPLETED · Phase 4
-
Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease
COMPLETED · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00576069 · 60 participants
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma
- NCT01297400 · 60 participants · Phase 2
Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns
- NCT01734122 · 60 participants
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
- NCT01804634 · 60 participants · Phase 2
Reduced Intensity Haploidentical BMT for High Risk Solid Tumors
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI