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NCT05741853 · ClinicalTrials.gov registry record · NA
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
A NA study of Alzheimer Disease and Dementia, sponsored by University of Texas at Austin.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 3
- Study locations
NCT05741853 is a NA study of Alzheimer Disease and Dementia that is actively recruiting participants, run by University of Texas at Austin. The registered enrollment target is 60 participants, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (98% lower). The trial reports 3 study locations across 2 states.
The verdict
NCT05741853, a NA study of Alzheimer Disease and Dementia, is actively recruiting participants, sponsored by University of Texas at Austin.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 3
- Study locations
Study Summary
Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA. The overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how "strong" each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA (60 individuals will be recruited). The investigators will conduct an assessment before treatment, after treatment and at two follow-ups (6 and 12-months post-treatment) in both languages. When possible, a structural scan of the brain (magnetic resonance image) will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment. In addition to the intervention described herein, 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention. Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA.
Conditions Studied
Interventions
- BEHAVIORAL Video-Implemented Script Training for Aphasia (VISTA)
- BEHAVIORAL Lexical Retrieval Training (LRT)
Study Locations (3)
Other
- Hospital de la Santa Creu i Sant Pau - Barcelona
- Hospital Clínic de Barcelona - Barcelona
Texas
- University of Texas at Austin - Austin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2023-05-01 |
| Est. Completion | 2027-11-30 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05741853
The ClinicalTrials.gov registry entry for NCT05741853 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (98% lower). The listed sponsor is University of Texas at Austin, which has 257 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 2 interventions - of which Video-Implemented Script Training for Aphasia (VISTA) is the first listed.
NCT05741853 reports 3 study locations spanning 2 distinct geographic areas - top geographies include Other, Texas.
Frequently Asked Questions
What is clinical trial NCT05741853 about?
NCT05741853 is a clinical study titled "Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia". Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need...
What is the current status of trial NCT05741853?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2023-05-01. Estimated completion is 2027-11-30.
What conditions does trial NCT05741853 study?
This clinical trial studies the following conditions: Alzheimer Disease, Dementia, Primary Progressive Aphasia, Neurodegenerative Diseases, Dysarthria.
What interventions are being tested in trial NCT05741853?
The interventions under investigation include: Video-Implemented Script Training for Aphasia (VISTA) (BEHAVIORAL), Lexical Retrieval Training (LRT) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05741853?
This trial is sponsored by University of Texas at Austin, which has 257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05741853 being conducted?
This trial has 3 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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