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Alzheimer Disease clinical trials
155 of 312 indexed Alzheimer Disease trials are currently recruiting.
312 US clinical trials · 155 currently recruiting
Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.
The research picture
Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.
- 155
- recruiting participants now
- 50%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Eli Lilly and Company
Active & Recent Trials
312 total, page 4 of 7
Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease
MMI (Medical Microinstruments, Inc.)
NCT07178210
Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia
Mclean Hospital
NCT04075435
A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK
University College, London
NCT06372821
Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042
NeuroPro Therapeutics
NCT07222878
Human Mesenchymal Stem Cells (hMSC) in Behavioral Problems Due to Alzheimer's Disease.
Bernard (Barry) Baumel
NCT06781333
ED-LEAD: Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care
NYU Langone Health
NCT06079203
Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias
Anne Murray
NCT07224139
Changing Talk Online Training (CHATO) National Trial
University of Kansas Medical Center
NCT04610944
The Brain Health Study: A Pragmatic, Patient-Centered Trial
Kaiser Permanente
NCT05356702
A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
Eli Lilly and Company
NCT05026866
A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
Eli Lilly and Company
NCT04437511
Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
AriBio Co.
NCT05531526
Davos Alzheimer's Collaborative Study: Sequential Administration of Digital Testing To Screen For Cognitive Impairment Followed By Blood Based Biomarkers To Assist With Timely Detection And Accurate Diagnosis Of Alzheimer's Disease
AdventHealth Translational Research Institute
NCT05379348
A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
Eli Lilly and Company
NCT02951598
Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease
Tharick Pascoal
NCT05361382
Minnesota Inclusive LTSS for LGBTQ Seniors
University of Minnesota
NCT05530590
A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011)
Cognito Therapeutics
NCT05637801
BRINK (BRain In Kidney Disease) Memory Study 2.0
Anne Murray
NCT04975464
A Study to Evaluate Efficacy and Safety of Intravenous Sabirnetug in Participants With Early Alzheimer's Disease (ALTITUDE-AD)
Acumen Pharmaceuticals
NCT06335173
A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease
Janssen Research & Development
NCT04619420
Returning Research Results That Indicate Risk of Alzheimer Disease Dementia to Healthy Participants in Longitudinal Studies
Washington University School of Medicine
NCT04699786
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
C2N Diagnostics
NCT06025877
A Study of Caregiver Connections Via Technology in Dementia
Mayo Clinic
NCT05779839
A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia (MK-1167-008)
Merck Sharp & Dohme
NCT06721156
The PorchLight Project
University of Minnesota
NCT05550727
A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease
Eli Lilly and Company
NCT06538116
Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults
Northwestern University
NCT03960476
A Spanish-language Caregiver-Enabled Care Program
Ceresti Health
NCT06631144
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
Rush University Medical Center
NCT04337255
Effect of 10 mg Xanamem on Dementia Due to Alzheimer's Disease
Actinogen Medical
NCT06125951
A Study of ONO-2020 in Participants With Mild to Moderate Alzheimer's Disease
Ono Pharmaceutical Co.
NCT06881836
Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)
NYU Langone Health
NCT04784416
The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's
Weill Medical College of Cornell University
NCT03649724
Effects of Dance and Music Appreciation on Brain Health and Fitness in People at Risk for Alzheimer's Disease
Wake Forest University Health Sciences
NCT05507905
Sleep Aging and Risk for Alzheimer's 2.0
NYU Langone Health
NCT03278119
Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study
University of Pennsylvania
NCT05393388
Phase 2 Estimation Study of Fixed Dose Drugs Combination Type of Polypill
Noah Pharmaceuticals
NCT06597058
Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure
University of Michigan
NCT05584241
Plasma Hydrogen Sulfide as a Biomarker for Alzheimer's Disease and Related Dementias
Louisiana State University Health Sciences Center Shreveport
NCT05060848
Developing a Communication Intervention for People With Memory Challenges and Their Care Partners
Weill Medical College of Cornell University
NCT05143255
High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease
Massachusetts Institute of Technology
NCT04042922
Music, Social Attention, and Dementia
University of California, San Francisco
NCT06768996
Preventing Medication Mismanagement in People Living with Dementia Through Automated Medication Dispensing with Facial Recognition and Video Observation
HiDO Technologies
NCT06691256
A Scalable Nutrition Adherence Intervention
Florida State University
NCT06121986
Fluselenamyl - Beta Amyloid PET Imaging for Alzheimer Disease
Washington University School of Medicine
NCT05731440
Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study
Mayo Clinic
NCT02740634
Multi-Center Study of Sensory Stimulation to Improve Brain Function
Cognito Therapeutics
NCT03556280
Investigation of Inflammation Using [C-11]-CS1P1
Tammie L. S. Benzinger, MD, PhD
NCT04517552
Multi-Center Development of a Novel Diagnostic Test for Alzheimer's Disease
Boston University
NCT03560960
Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease
University of California, San Diego
NCT03703856
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 53 |
| Phase 2 | 51 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alzheimer Disease Trial Landscape
312 indexed Alzheimer Disease studies · 155 recruiting (50%).
Phase mix: 26 late (III/IV) vs 104 early (I/II).
Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alzheimer Disease?
PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alzheimer Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.