Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 155 recruiting now official registry

Alzheimer Disease clinical trials

155 of 312 indexed Alzheimer Disease trials are currently recruiting.

312 US clinical trials · 155 currently recruiting

Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.

The research picture

Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.

155
recruiting participants now
50%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
13
top sponsor: Eli Lilly and Company
Phase 153Phase 251Phase 318Phase 48

Active & Recent Trials

312 total, page 4 of 7

RECRUITING NA 15 participants

Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease

MMI (Medical Microinstruments, Inc.)

NCT07178210

RECRUITING Early Phase 1 12 participants

Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia

Mclean Hospital

NCT04075435

RECRUITING Phase 1 10 participants

A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

University College, London

NCT06372821

RECRUITING Phase 1 8 participants

Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042

NeuroPro Therapeutics

NCT07222878

RECRUITING Phase 2 8 participants

Human Mesenchymal Stem Cells (hMSC) in Behavioral Problems Due to Alzheimer's Disease.

Bernard (Barry) Baumel

NCT06781333

ACTIVE NOT RECRUITING NA 19,200 participants

ED-LEAD: Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care

NYU Langone Health

NCT06079203

ACTIVE NOT RECRUITING 13,435 participants

Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias

Anne Murray

NCT07224139

ACTIVE NOT RECRUITING NA 5,043 participants

Changing Talk Online Training (CHATO) National Trial

University of Kansas Medical Center

NCT04610944

ACTIVE NOT RECRUITING NA 3,417 participants

The Brain Health Study: A Pragmatic, Patient-Centered Trial

Kaiser Permanente

NCT05356702

ACTIVE NOT RECRUITING Phase 3 2,996 participants

A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)

Eli Lilly and Company

NCT05026866

ACTIVE NOT RECRUITING Phase 3 1,736 participants

A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)

Eli Lilly and Company

NCT04437511

ACTIVE NOT RECRUITING Phase 3 1,535 participants

Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)

AriBio Co.

NCT05531526

ACTIVE NOT RECRUITING 1,423 participants

Davos Alzheimer's Collaborative Study: Sequential Administration of Digital Testing To Screen For Cognitive Impairment Followed By Blood Based Biomarkers To Assist With Timely Detection And Accurate Diagnosis Of Alzheimer's Disease

AdventHealth Translational Research Institute

NCT05379348

ACTIVE NOT RECRUITING 1,400 participants

A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)

Eli Lilly and Company

NCT02951598

ACTIVE NOT RECRUITING Phase 1 822 participants

Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease

Tharick Pascoal

NCT05361382

ACTIVE NOT RECRUITING NA 760 participants

Minnesota Inclusive LTSS for LGBTQ Seniors

University of Minnesota

NCT05530590

ACTIVE NOT RECRUITING NA 670 participants

A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011)

Cognito Therapeutics

NCT05637801

ACTIVE NOT RECRUITING 600 participants

BRINK (BRain In Kidney Disease) Memory Study 2.0

Anne Murray

NCT04975464

ACTIVE NOT RECRUITING Phase 2 542 participants

A Study to Evaluate Efficacy and Safety of Intravenous Sabirnetug in Participants With Early Alzheimer's Disease (ALTITUDE-AD)

Acumen Pharmaceuticals

NCT06335173

ACTIVE NOT RECRUITING Phase 2 523 participants

A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease

Janssen Research & Development

NCT04619420

ACTIVE NOT RECRUITING NA 450 participants

Returning Research Results That Indicate Risk of Alzheimer Disease Dementia to Healthy Participants in Longitudinal Studies

Washington University School of Medicine

NCT04699786

ACTIVE NOT RECRUITING 400 participants

Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey

C2N Diagnostics

NCT06025877

ACTIVE NOT RECRUITING NA 355 participants

A Study of Caregiver Connections Via Technology in Dementia

Mayo Clinic

NCT05779839

ACTIVE NOT RECRUITING Phase 2 350 participants

A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia (MK-1167-008)

Merck Sharp & Dohme

NCT06721156

ACTIVE NOT RECRUITING NA 342 participants

The PorchLight Project

University of Minnesota

NCT05550727

ACTIVE NOT RECRUITING Phase 2 300 participants

A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease

Eli Lilly and Company

NCT06538116

ACTIVE NOT RECRUITING NA 293 participants

Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults

Northwestern University

NCT03960476

ACTIVE NOT RECRUITING NA 270 participants

A Spanish-language Caregiver-Enabled Care Program

Ceresti Health

NCT06631144

ACTIVE NOT RECRUITING NA 250 participants

Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients

Rush University Medical Center

NCT04337255

ACTIVE NOT RECRUITING Phase 2 247 participants

Effect of 10 mg Xanamem on Dementia Due to Alzheimer's Disease

Actinogen Medical

NCT06125951

ACTIVE NOT RECRUITING Phase 2 240 participants

A Study of ONO-2020 in Participants With Mild to Moderate Alzheimer's Disease

Ono Pharmaceutical Co.

NCT06881836

ACTIVE NOT RECRUITING Phase 2 196 participants

Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)

NYU Langone Health

NCT04784416

ACTIVE NOT RECRUITING Phase 2 180 participants

The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's

Weill Medical College of Cornell University

NCT03649724

ACTIVE NOT RECRUITING NA 165 participants

Effects of Dance and Music Appreciation on Brain Health and Fitness in People at Risk for Alzheimer's Disease

Wake Forest University Health Sciences

NCT05507905

ACTIVE NOT RECRUITING 158 participants

Sleep Aging and Risk for Alzheimer's 2.0

NYU Langone Health

NCT03278119

ACTIVE NOT RECRUITING 111 participants

Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study

University of Pennsylvania

NCT05393388

ACTIVE NOT RECRUITING Phase 2 103 participants

Phase 2 Estimation Study of Fixed Dose Drugs Combination Type of Polypill

Noah Pharmaceuticals

NCT06597058

ACTIVE NOT RECRUITING NA 100 participants

Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure

University of Michigan

NCT05584241

ACTIVE NOT RECRUITING 100 participants

Plasma Hydrogen Sulfide as a Biomarker for Alzheimer's Disease and Related Dementias

Louisiana State University Health Sciences Center Shreveport

NCT05060848

ACTIVE NOT RECRUITING NA 90 participants

Developing a Communication Intervention for People With Memory Challenges and Their Care Partners

Weill Medical College of Cornell University

NCT05143255

ACTIVE NOT RECRUITING NA 80 participants

High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease

Massachusetts Institute of Technology

NCT04042922

ACTIVE NOT RECRUITING NA 80 participants

Music, Social Attention, and Dementia

University of California, San Francisco

NCT06768996

ACTIVE NOT RECRUITING Phase 2 70 participants

Preventing Medication Mismanagement in People Living with Dementia Through Automated Medication Dispensing with Facial Recognition and Video Observation

HiDO Technologies

NCT06691256

ACTIVE NOT RECRUITING NA 61 participants

A Scalable Nutrition Adherence Intervention

Florida State University

NCT06121986

ACTIVE NOT RECRUITING 60 participants

Fluselenamyl - Beta Amyloid PET Imaging for Alzheimer Disease

Washington University School of Medicine

NCT05731440

ACTIVE NOT RECRUITING NA 60 participants

Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study

Mayo Clinic

NCT02740634

ACTIVE NOT RECRUITING NA 60 participants

Multi-Center Study of Sensory Stimulation to Improve Brain Function

Cognito Therapeutics

NCT03556280

ACTIVE NOT RECRUITING 60 participants

Investigation of Inflammation Using [C-11]-CS1P1

Tammie L. S. Benzinger, MD, PhD

NCT04517552

ACTIVE NOT RECRUITING Early Phase 1 57 participants

Multi-Center Development of a Novel Diagnostic Test for Alzheimer's Disease

Boston University

NCT03560960

ACTIVE NOT RECRUITING Phase 4 53 participants

Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease

University of California, San Diego

NCT03703856

← Previous Page 4 of 7 Next →

Phase Distribution

PhaseTrial count
Phase 1 53
Phase 2 51
Phase 3 18
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alzheimer Disease Trial Landscape

312 indexed Alzheimer Disease studies · 155 recruiting (50%).

Phase mix: 26 late (III/IV) vs 104 early (I/II).

Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alzheimer Disease?

PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alzheimer Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.