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NCT04274998 · ClinicalTrials.gov registry record · Early Phase 1

Neuroinflammation Imaging in AD

A Early Phase 1 study of Alzheimer Disease and Healthy Volunteer, sponsored by University of Pennsylvania.

Recruiting
Registry status
Early Phase 1
Development phase
20
Enrollment target
1
Study location

NCT04274998 is a Early Phase 1 study of Alzheimer Disease and Healthy Volunteer that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 20 participants, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04274998, a Early Phase 1 study of Alzheimer Disease and Healthy Volunteer, is actively recruiting participants, sponsored by University of Pennsylvania.

RECRUITING
Registry status
Early Phase 1
Development phase
20 participants
Enrollment target
1
Study location

Study Summary

This research study is being done to learn more about inflammation in the brain using Positron Emission Tomography/Computed Tomography (PET/CT) imaging in people with Alzheimer's Disease/Mild Cognitive Impairment or healthy controls. If the subject agrees to be in this study, she/ he will have a PET/CT scan using the investigational radiotracer \[18F\]NOS. A subject with a specific genetic polymorphism may also agree to be in the sub-study in which she/he will have another PET/CT scan using the investigational tracer \[11C\]PBR28 for comparison with the FNOS \[18F\]NOS scan. For subjects who agree to this sub-study they may undergo the brain PET/CT scan with \[11C\]PBR28 either on the same day as the \[18F\]NOS PET/CT or on another day. The subject may have a screening visit before the PET/CT scan visit if the investigator needs to confirm the subject is able to be in the study. A blood sample will be taken before the scans. Additional blood samples will be taken during the PET scans. Subjects must also agree to have an MRI scan for this research study if she/he has not had a recent scan that the study doctor decides can be used for this study.

Conditions Studied

Alzheimer Disease Healthy Volunteer

Interventions

  • DRUG [18F]NOS
  • DRUG [11C]PBR28

Study Locations (1)

Pennsylvania

  • University of Pennsylvania - Philadelphia

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2020-03-03
Est. Completion 2027-03-01
Phase Early Phase 1

Sponsor

University of Pennsylvania

1,423 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04274998

The ClinicalTrials.gov registry entry for NCT04274998 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (99% lower). The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 2 interventions - of which [18F]NOS is the first listed.

NCT04274998 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT04274998 about?

NCT04274998 is a clinical study titled "Neuroinflammation Imaging in AD". This research study is being done to learn more about inflammation in the brain using Positron Emission Tomography/Computed Tomography (PET/CT) imaging in people with Alzheimer's Disease/Mild Cognitive Impairment or healthy controls. If the subject agrees to be in this study, she/ he will have a PE...

What is the current status of trial NCT04274998?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 20 participants. The study started on 2020-03-03. Estimated completion is 2027-03-01.

What conditions does trial NCT04274998 study?

This clinical trial studies the following conditions: Alzheimer Disease, Healthy Volunteer.

What interventions are being tested in trial NCT04274998?

The interventions under investigation include: [18F]NOS (DRUG), [11C]PBR28 (DRUG).

Who is sponsoring clinical trial NCT04274998?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04274998 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.