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NCT04740580 · ClinicalTrials.gov registry record · Early Phase 1

Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease

A Early Phase 1 study of Alzheimer Disease, sponsored by Baylor College of Medicine.

Recruiting
Registry status
Early Phase 1
Development phase
52
Enrollment target
1
Study location

NCT04740580 is a Early Phase 1 study of Alzheimer Disease that is actively recruiting participants, run by Baylor College of Medicine. The registered enrollment target is 52 participants, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04740580, a Early Phase 1 study of Alzheimer Disease, is actively recruiting participants, sponsored by Baylor College of Medicine.

RECRUITING
Registry status
Early Phase 1
Development phase
52 participants
Enrollment target
1
Study location

Study Summary

Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD. This trial will investigate the effects of supplementing glycine and N-acetylcysteine vs. alanine as placebo on these defects in AD, and examine the effects on cognition.

Conditions Studied

Alzheimer Disease

Interventions

  • DIETARY_SUPPLEMENT Glycine
  • DIETARY_SUPPLEMENT N-acetylcysteine
  • DIETARY_SUPPLEMENT Alanine

Study Locations (1)

Texas

  • Baylor College of Medicine - Houston

Trial Details

FieldValue
Enrollment Target 52 participants
Start Date 2022-02-15
Est. Completion 2026-12-31
Phase Early Phase 1

Sponsor

Baylor College of Medicine

616 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04740580

The ClinicalTrials.gov registry entry for NCT04740580 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 52 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (98% lower). The listed sponsor is Baylor College of Medicine, which has 616 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Alzheimer Disease appearing as the primary indexed condition, and to 3 interventions - of which Glycine is the first listed.

NCT04740580 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT04740580 about?

NCT04740580 is a clinical study titled "Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease". Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD. This trial will investigate the effects of supplementing glycine and N-acetylcyst...

What is the current status of trial NCT04740580?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 52 participants. The study started on 2022-02-15. Estimated completion is 2026-12-31.

What conditions does trial NCT04740580 study?

This clinical trial studies the following conditions: Alzheimer Disease.

What interventions are being tested in trial NCT04740580?

The interventions under investigation include: Glycine (DIETARY_SUPPLEMENT), N-acetylcysteine (DIETARY_SUPPLEMENT), Alanine (DIETARY_SUPPLEMENT).

Who is sponsoring clinical trial NCT04740580?

This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04740580 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.