Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING NA

ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease

NCT03671889 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the safety and efficacy of the ExAblate Model 4000 Type 2.0 System as a tool to disrupt the blood-brain barrier (BBB) in patients with probable Alzheimer's Disease (AD).

Conditions Studied

Interventions

  • DEVICE Blood Brain Barrier (BBB) Disruption

Study Locations (10)

Florida

  • Delray Medical Center & Florida Atlantic University — Delray Beach
  • Broward Health Medical Center & The University of Florida — Fort Lauderdale
  • University of Florida Health Shands — Gainesville
  • Baptist Health South Florida & Florida International University — Miami
  • Advent Health — Orlando
  • Tampa General Hospital — Tampa

New York

  • Weill Cornell Medicine — New York

Ohio

  • The Ohio State University -Wexner Medical Center — Columbus

Texas

  • University of Texas Southwestern Medical Center — Dallas

West Virginia

  • West Virginia University Rockefeller Neuroscience Center — Morgantown

Trial Details

FieldValue
Enrollment Target 50 participants
Start Date 2018-09-28
Est. Completion 2030-01
Phase NA

Sponsor

InSightec

76 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03671889

The ClinicalTrials.gov registry entry for NCT03671889 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is InSightec, which has 76 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention — of which Blood Brain Barrier (BBB) Disruption is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03671889 reports 10 study locations spanning 5 distinct geographic areas — top geographies include Florida, New York, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03671889 about?

NCT03671889 is a clinical study titled "ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease". The purpose of this study is to evaluate the safety and efficacy of the ExAblate Model 4000 Type 2.0 System as a tool to disrupt the blood-brain barrier (BBB) in patients with probable Alzheimer's Disease (AD).

What is the current status of trial NCT03671889?

This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2018-09-28. Estimated completion is 2030-01.

What conditions does trial NCT03671889 study?

This clinical trial studies the following conditions: Alzheimer Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03671889?

The interventions under investigation include: Blood Brain Barrier (BBB) Disruption (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03671889?

This trial is sponsored by InSightec, which has 76 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03671889 being conducted?

This trial has 10 study locations across Florida, New York, Ohio, Texas, West Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial