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ClinicalTrials.gov 109 recruiting now official registry

Alcohol Use Disorder clinical trials

109 of 185 indexed Alcohol Use Disorder trials are currently recruiting.

185 US clinical trials · 109 currently recruiting

Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.

The research picture

Alcohol Use Disorder has 185 registered US clinical trials, 109 of them open to new participants right now, about 59% of the total.

109
recruiting participants now
59%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
13
top sponsor: Yale University
Phase 126Phase 249Phase 35Phase 43

Active & Recent Trials

185 total, page 4 of 4

COMPLETED NA 100 participants

Alcohol Misuse Intervention in Active Duty US Navy Personnel

University of New Mexi

NCT04893044

COMPLETED Phase 1 95 participants

Cannabidiol as a Treatment for AUD Comorbid With PTSD

NYU Langone Health

NCT03248167

COMPLETED Phase 1 91 participants

The Role of Neuroactive Steroids in Stress, Alcohol Craving and Alcohol Use in Alcohol Use Disorders

Yale University

NCT03872128

COMPLETED Phase 2 90 participants

Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control

Medical University of South Carolina

NCT02949934

COMPLETED NA 88 participants

Substance Use Treatment and Recovery Team (START)

RAND

NCT04314648

COMPLETED NA 83 participants

Effect of CBT Microinterventions on Mechanisms of Behavior Change Among Adults With AUD

University of Massachusetts, Worcester

NCT03661853

COMPLETED Early Phase 1 81 participants

Orexin Receptor Antagonists as Modulators of Threat Sensitivity in Individuals With Alcohol Use Disorder

Ohio State University

NCT05656534

COMPLETED NA 74 participants

Dual Reinforcement Contingency Management for Alcohol Use Disorders

UConn Health

NCT04064463

COMPLETED NA 68 participants

Building and Pilot Testing a Couples-based Smartphone Systems to Address Alcohol Use Disorder

University of Wisconsin, Madison

NCT04059549

COMPLETED Phase 1 64 participants

Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies

Kent State University

NCT04286867

COMPLETED NA 60 participants

Acute Alcohol Response In Bipolar Disorder: a fMRI Study

University of Texas at Austin

NCT04063384

COMPLETED Phase 2 54 participants

Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics

Medical University of South Carolina

NCT03220776

COMPLETED Phase 2 51 participants

Medication Development in Alcoholism: Apremilast Versus Placebo

The Scripps Research Institute

NCT03175549

COMPLETED Phase 2 50 participants

Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo

The Scripps Research Institute

NCT04466215

COMPLETED Phase 2 48 participants

Semaglutide for Alcohol Use Disorder

University of North Carolina, Chapel Hill

NCT05520775

COMPLETED Phase 1 47 participants

Human Laboratory Study of Varenicline for Alcohol Use Disorder

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT03035708

COMPLETED 46 participants

MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study

Boston Medical Center

NCT03718104

COMPLETED Phase 2 45 participants

CBD for the Treatment of Alcohol Use Disorder

University of Colorado, Denver

NCT04873453

COMPLETED NA 45 participants

Effects of tDCS Paired With Cognitive Training on Brain Networks Associated With Alcohol Use Disorder in Veterans

VA Office of Research and Development

NCT04574167

COMPLETED Phase 2 40 participants

Study of Sunobinop on Craving in Alcohol Use Disorder

Imbrium Therapeutics

NCT06545929

COMPLETED Phase 2 40 participants

Acamprosate Initiated During Alcohol Detoxification

Forest Laboratories

NCT00360594

COMPLETED Early Phase 1 39 participants

[C-11]PiB PET Imaging in Alcohol Use Disorders

University of Pittsburgh

NCT03746366

COMPLETED NA 35 participants

EMPOWER AUD Pivotal Trial

Theranova, L.L.C.

NCT05948605

COMPLETED Phase 2 31 participants

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

Seattle Institute for Biomedical and Clinical Research

NCT02322047

COMPLETED NA 30 participants

Addiction Treatment Outcome Monitoring Study

University of Washington

NCT04155385

COMPLETED NA 29 participants

Families With Substance Use and Psychosis: A Pilot Study

Mclean Hospital

NCT04284813

COMPLETED Phase 1 27 participants

Effects of Cannabidiol in Alcohol Use Disorder

NYU Langone Health

NCT03252756

COMPLETED NA 17 participants

Treatment Parameters for the Empower Neuromodulation System (ENS)

Theranova, L.L.C.

NCT03807544

COMPLETED NA 17 participants

Phosphatidylethanol-Based Contingency Management for Housing

Washington State University

NCT04038021

COMPLETED NA 16 participants

Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma

University of Massachusetts, Worcester

NCT03845985

COMPLETED Phase 2 16 participants

Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.

University of Pittsburgh

NCT02185131

COMPLETED Phase 2 12 participants

Modafinil for the Treatment of Alcohol Use Disorders

The Mind Research Network

NCT03424681

COMPLETED Phase 2 11 participants

Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial

University of Pittsburgh

NCT02646449

COMPLETED Phase 2 11 participants

Oxytocin and Stress Response in Alcohol Use Disorder

Medical University of South Carolina

NCT03610633

COMPLETED NA 9 participants

CCTAP: Cognitive Control Training for Treatment of AUD-PTSD

Posit Science Corporation

NCT03200028

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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 49
Phase 3 5
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alcohol Use Disorder Trial Landscape

185 indexed Alcohol Use Disorder studies · 109 recruiting (59%).

Phase mix: 8 late (III/IV) vs 75 early (I/II).

Top sponsor: Yale University (13 trials), 9 others listed. 35 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alcohol Use Disorder?

PlainTrial tracks 185 US clinical trials for Alcohol Use Disorder, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alcohol Use Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.