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Alcohol Use Disorder clinical trials
109 of 185 indexed Alcohol Use Disorder trials are currently recruiting.
185 US clinical trials · 109 currently recruiting
Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.
The research picture
Alcohol Use Disorder has 185 registered US clinical trials, 109 of them open to new participants right now, about 59% of the total.
- 109
- recruiting participants now
- 59%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Yale University
Active & Recent Trials
185 total, page 4 of 4
Alcohol Misuse Intervention in Active Duty US Navy Personnel
University of New Mexi
NCT04893044
Cannabidiol as a Treatment for AUD Comorbid With PTSD
NYU Langone Health
NCT03248167
The Role of Neuroactive Steroids in Stress, Alcohol Craving and Alcohol Use in Alcohol Use Disorders
Yale University
NCT03872128
Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
Medical University of South Carolina
NCT02949934
Substance Use Treatment and Recovery Team (START)
RAND
NCT04314648
Effect of CBT Microinterventions on Mechanisms of Behavior Change Among Adults With AUD
University of Massachusetts, Worcester
NCT03661853
Orexin Receptor Antagonists as Modulators of Threat Sensitivity in Individuals With Alcohol Use Disorder
Ohio State University
NCT05656534
Dual Reinforcement Contingency Management for Alcohol Use Disorders
UConn Health
NCT04064463
Building and Pilot Testing a Couples-based Smartphone Systems to Address Alcohol Use Disorder
University of Wisconsin, Madison
NCT04059549
Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies
Kent State University
NCT04286867
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
University of Texas at Austin
NCT04063384
Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics
Medical University of South Carolina
NCT03220776
Medication Development in Alcoholism: Apremilast Versus Placebo
The Scripps Research Institute
NCT03175549
Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo
The Scripps Research Institute
NCT04466215
Semaglutide for Alcohol Use Disorder
University of North Carolina, Chapel Hill
NCT05520775
Human Laboratory Study of Varenicline for Alcohol Use Disorder
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT03035708
MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study
Boston Medical Center
NCT03718104
CBD for the Treatment of Alcohol Use Disorder
University of Colorado, Denver
NCT04873453
Effects of tDCS Paired With Cognitive Training on Brain Networks Associated With Alcohol Use Disorder in Veterans
VA Office of Research and Development
NCT04574167
Study of Sunobinop on Craving in Alcohol Use Disorder
Imbrium Therapeutics
NCT06545929
Acamprosate Initiated During Alcohol Detoxification
Forest Laboratories
NCT00360594
[C-11]PiB PET Imaging in Alcohol Use Disorders
University of Pittsburgh
NCT03746366
EMPOWER AUD Pivotal Trial
Theranova, L.L.C.
NCT05948605
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
Seattle Institute for Biomedical and Clinical Research
NCT02322047
Addiction Treatment Outcome Monitoring Study
University of Washington
NCT04155385
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
Effects of Cannabidiol in Alcohol Use Disorder
NYU Langone Health
NCT03252756
Treatment Parameters for the Empower Neuromodulation System (ENS)
Theranova, L.L.C.
NCT03807544
Phosphatidylethanol-Based Contingency Management for Housing
Washington State University
NCT04038021
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
University of Massachusetts, Worcester
NCT03845985
Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.
University of Pittsburgh
NCT02185131
Modafinil for the Treatment of Alcohol Use Disorders
The Mind Research Network
NCT03424681
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial
University of Pittsburgh
NCT02646449
Oxytocin and Stress Response in Alcohol Use Disorder
Medical University of South Carolina
NCT03610633
CCTAP: Cognitive Control Training for Treatment of AUD-PTSD
Posit Science Corporation
NCT03200028
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 26 |
| Phase 2 | 49 |
| Phase 3 | 5 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alcohol Use Disorder Trial Landscape
185 indexed Alcohol Use Disorder studies · 109 recruiting (59%).
Phase mix: 8 late (III/IV) vs 75 early (I/II).
Top sponsor: Yale University (13 trials), 9 others listed. 35 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alcohol Use Disorder?
PlainTrial tracks 185 US clinical trials for Alcohol Use Disorder, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alcohol Use Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.