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ClinicalTrials.gov 58 recruiting now official registry

Acute Lymphoblastic Leukemia clinical trials

58 of 132 indexed Acute Lymphoblastic Leukemia trials are currently recruiting.

132 US clinical trials · 58 currently recruiting

Acute Lymphoblastic Leukemia is the subject of 132 registered US clinical trials on ClinicalTrials.gov, 58 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 97 in Phase 1-2 (earlier-stage). The most active sponsor is City of Hope Medical Center, running 15 of these trials.

The research picture

Acute Lymphoblastic Leukemia has 132 registered US clinical trials, 58 of them open to new participants right now, about 44% of the total.

58
recruiting participants now
44%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
15
top sponsor: City of Hope Medical Center
Phase 149Phase 248Phase 37Phase 41

Active & Recent Trials

132 total, page 2 of 3

RECRUITING Phase 2 20 participants

Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

University of Florida

NCT05800210

RECRUITING Phase 1 20 participants

Autologous CD22 CAR T Cells Following Commercial CD19 CAR T Cells in B Cell Malignancies

Stanford University

NCT06408194

RECRUITING Phase 1 15 participants

225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

City of Hope Medical Center

NCT06287944

RECRUITING Phase 1 15 participants

Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia

University of Chicago

NCT03571321

RECRUITING Early Phase 1 15 participants

Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia

City of Hope Medical Center

NCT06735690

RECRUITING Phase 1 12 participants

A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

Ossium Health

NCT05589896

RECRUITING Phase 1 10 participants

Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies

University of Utah

NCT06227026

RECRUITING Phase 1 7 participants

CalPeg for Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)

H. Lee Moffitt Cancer Center and Research Institute

NCT05581030

ACTIVE NOT RECRUITING Phase 3 9,350 participants

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

Children's Oncology Group

NCT01190930

ACTIVE NOT RECRUITING 9,000 participants

Cytogenetic Studies in Acute Leukemia and Multiple Myeloma

Alliance for Clinical Trials in Oncology

NCT00048958

ACTIVE NOT RECRUITING 1,564 participants

A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer

St. Jude Children's Research Hospital

NCT02256137

ACTIVE NOT RECRUITING 840 participants

Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic Leukemia

Alliance for Clinical Trials in Oncology

NCT00003861

ACTIVE NOT RECRUITING Phase 2 790 participants

Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

St. Jude Children's Research Hospital

NCT03117751

ACTIVE NOT RECRUITING Phase 3 570 participants

Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission

Children's Oncology Group

NCT01503632

ACTIVE NOT RECRUITING Phase 3 488 participants

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

National Cancer Institute (NCI)

NCT02003222

ACTIVE NOT RECRUITING Phase 3 475 participants

Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Children's Oncology Group

NCT03007147

ACTIVE NOT RECRUITING Phase 3 435 participants

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Children's Oncology Group

NCT05457556

ACTIVE NOT RECRUITING 350 participants

Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study

City of Hope Medical Center

NCT04537871

ACTIVE NOT RECRUITING NA 342 participants

A High Intensity Electronic Health Intervention for the Reduction of Learning Disparities in Childhood Cancer Survivors

City of Hope Medical Center

NCT05428176

ACTIVE NOT RECRUITING Phase 2 313 participants

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

Center for International Blood and Marrow Transplant Research

NCT06001385

ACTIVE NOT RECRUITING 307 participants

Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test

CareDx

NCT04635384

ACTIVE NOT RECRUITING Phase 2 300 participants

HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

Center for International Blood and Marrow Transplant Research

NCT04904588

ACTIVE NOT RECRUITING Phase 2 240 participants

SC-PEG Asparaginase vs. Oncaspar in Pediatric Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma

Dana-Farber Cancer Institute

NCT01574274

ACTIVE NOT RECRUITING Phase 1 217 participants

Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL

Novartis Pharmaceuticals

NCT03960840

ACTIVE NOT RECRUITING NA 214 participants

High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma

City of Hope Medical Center

NCT03178617

ACTIVE NOT RECRUITING Phase 3 165 participants

An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial

AbbVie

NCT03844048

ACTIVE NOT RECRUITING Phase 2 150 participants

MT2017-45: CAR-T Cell Therapy for Heme Malignancies

Masonic Cancer Center, University of Minnesota

NCT03642626

ACTIVE NOT RECRUITING Phase 1 120 participants

Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant

Bellicum Pharmaceuticals

NCT03301168

ACTIVE NOT RECRUITING 100 participants

Financial Distress During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United States

Children's Oncology Group

NCT04928599

ACTIVE NOT RECRUITING Phase 2 97 participants

Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia

National Cancer Institute (NCI)

NCT00792948

ACTIVE NOT RECRUITING Phase 1 93 participants

Precursor B Cell Acute Lymphoblastic Leukemia (B-ALL) Treated With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19

Memorial Sloan Kettering Cancer Center

NCT01044069

ACTIVE NOT RECRUITING Phase 2 88 participants

Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT01424982

ACTIVE NOT RECRUITING Phase 1 72 participants

huCART19-IL18 in CD19+ Cancers

University of Pennsylvania

NCT04684563

ACTIVE NOT RECRUITING Phase 2 53 participants

Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia

National Cancer Institute (NCI)

NCT02143414

ACTIVE NOT RECRUITING Phase 1 50 participants

Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I

St. Jude Children's Research Hospital

NCT02553460

ACTIVE NOT RECRUITING Phase 1 44 participants

A Study of Blinatumomab in Patients With Pre B-cell ALL and B-cell NHL as Post-allo-HSCT Remission Maintenance

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03114865

ACTIVE NOT RECRUITING Phase 2 40 participants

Inotuzumab Ozogamicin in Treating Patients With B-cell Acute Lymphocytic Leukemia With Positive Minimal Residual Disease

M.D. Anderson Cancer Center

NCT03441061

ACTIVE NOT RECRUITING NA 36 participants

Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)

St. Jude Children's Research Hospital

NCT04105530

ACTIVE NOT RECRUITING Phase 1 36 participants

Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant

Bellicum Pharmaceuticals

NCT01744223

ACTIVE NOT RECRUITING Phase 2 33 participants

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

City of Hope Medical Center

NCT04262843

ACTIVE NOT RECRUITING Phase 2 31 participants

Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes

Fred Hutchinson Cancer Center

NCT03399773

ACTIVE NOT RECRUITING Phase 2 30 participants

Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

University of Alabama at Birmingham

NCT04975555

ACTIVE NOT RECRUITING NA 30 participants

Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study

Ohio State University Comprehensive Cancer Center

NCT05972577

ACTIVE NOT RECRUITING Phase 2 26 participants

A Phase II Study of the Combination of Ponatinib With Mini-hyper CVD Chemotherapy and Venetoclax in Patients With Relapsed or Refractory T-cell Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT05268003

ACTIVE NOT RECRUITING Phase 2 22 participants

Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT03147612

ACTIVE NOT RECRUITING Phase 2 20 participants

Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants

City of Hope Medical Center

NCT05364762

ACTIVE NOT RECRUITING Phase 1 18 participants

Human AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Lymphoid Malignancies

Benjamin Tomlinson

NCT04732845

ACTIVE NOT RECRUITING NA 17 participants

Feasibility Neurocognitive Outcome After Transplant

Stanford University

NCT02300961

ACTIVE NOT RECRUITING Phase 2 17 participants

Blinatumomab and Tyrosine Kinase Inhibitor Therapy in People With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Memorial Sloan Kettering Cancer Center

NCT04329325

ACTIVE NOT RECRUITING Phase 1 17 participants

Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL

UNC Lineberger Comprehensive Cancer Center

NCT03016377

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Phase Distribution

PhaseTrial count
Phase 1 49
Phase 2 48
Phase 3 7
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Lymphoblastic Leukemia Trial Landscape

132 indexed Acute Lymphoblastic Leukemia studies · 58 recruiting (44%).

Phase mix: 8 late (III/IV) vs 97 early (I/II).

Top sponsor: City of Hope Medical Center (15 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Lymphoblastic Leukemia?

PlainTrial tracks 132 US clinical trials for Acute Lymphoblastic Leukemia, of which 58 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Lymphoblastic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.