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Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant
NCT01744223 · View on ClinicalTrials.gov ↗
Study Summary
This study will evaluate patients with blood cell cancers who are going to have an allogeneic (donor) blood stem cell transplant from a partially matched relative. The research study will test whether immune cells, called T cells, which come from the donor relative and are specially grown in the laboratory and then given back to the patient along with the stem cell transplant (T cell addback), can help the immune system recover faster after the transplant. As a safety measure, these T cells have been "programmed" with a "self-destruct switch" so that if, after they have been given to the patient, the T cells start to react against the tissues (called "graft versus host" disease, GVHD), the T cells can be destroyed.
Conditions Studied
Interventions
- DRUG Rimiducid
- BIOLOGICAL BPX-501 dose 1
- BIOLOGICAL BPX-501 dose 2
- BIOLOGICAL BPX-501 dose 3
- BIOLOGICAL BPX-501 dose 4
Study Locations (8)
New York
- Roswell Park Cancer Institute — Buffalo
- Memorial Sloan Kettering Cancer Center — New York
Texas
- Baylor Sammons Cancer Center — Dallas
- UT Southwestern Medical Center — Dallas
Georgia
- Emory University Winship Cancer Institute — Atlanta
Ohio
- University Hospitals of Cleveland — Cleveland
Oregon
- Oregon Health & Science University — Portland
Washington
- Fred Hutchinson Cancer Research Center — Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2013-03 |
| Est. Completion | 2032-10 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01744223
The ClinicalTrials.gov registry entry for NCT01744223 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 36 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bellicum Pharmaceuticals, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Lymphoma appearing as the primary indexed condition, and to 5 interventions — of which Rimiducid is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01744223 reports 8 study locations spanning 6 distinct geographic areas — top geographies include New York, Texas, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01744223 about?
NCT01744223 is a clinical study titled "Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant". This study will evaluate patients with blood cell cancers who are going to have an allogeneic (donor) blood stem cell transplant from a partially matched relative. The research study will test whether immune cells, called T cells, which come from the donor relative and are specially grown in the lab...
What is the current status of trial NCT01744223?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 36 participants. The study started on 2013-03. Estimated completion is 2032-10.
What conditions does trial NCT01744223 study?
This clinical trial studies the following conditions: Lymphoma, Myelodysplastic Syndromes, Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT01744223?
The interventions under investigation include: Rimiducid (DRUG), BPX-501 dose 1 (BIOLOGICAL), BPX-501 dose 2 (BIOLOGICAL), BPX-501 dose 3 (BIOLOGICAL), BPX-501 dose 4 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT01744223?
This trial is sponsored by Bellicum Pharmaceuticals, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01744223 being conducted?
This trial has 8 study locations across Georgia, New York, Ohio, Oregon, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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