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NCT04537871 · ClinicalTrials.gov registry record
Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study
A clinical trial of Acute Myeloid Leukemia and Myelodysplastic Syndrome, sponsored by City of Hope Medical Center.
- Active
- Registry status
- 350
- Enrollment target
- 1
- Study location
NCT04537871: Active study of Acute Myeloid Leukemia and Myelodysplastic Syndrome, sponsored by City of Hope Medical Center.
NCT04537871 is a study of Acute Myeloid Leukemia and Myelodysplastic Syndrome that is active but no longer recruiting, run by City of Hope Medical Center. The registered enrollment target is 350 participants, above the 115-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target (204% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04537871, a study of Acute Myeloid Leukemia and Myelodysplastic Syndrome, is active but no longer recruiting, sponsored by City of Hope Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- 350 participants
- Enrollment target
- 1
- Study location
Study Summary
This study evaluates how well the heart, lungs, and muscles are working individually, and how these systems are working together in transplant survivors. Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for developing cardiovascular disease.
Primary Outcome
We will measure initial VO2peak in patients prior to HCT and its post-HCT trajectory over time; compare VO2peak in HCT survivors at baseline (pre-HCT), 6m, 1Y, and 2Y post-HCT to established age- and sex-normative data; and define the association between VO2peak and self-reported health-related quality of life (HRQOL) at baseline/over time.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- PROCEDURE Echocardiography
- PROCEDURE Bioelectric Impedance Analysis
- PROCEDURE Cardiopulmonary Exercise Testing
- PROCEDURE Physical Performance Testing
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 350 participants |
| Start Date | 2020-11-18 |
| Est. Completion | 2026-06-30 |
What the registry record for NCT04537871 still lists
NCT04537871 is an observational study that tracks outcomes without assigning an intervention. The registered 350 participants enrollment target is mid-sized for trials with a published cap, above the 115-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target (204% higher).
The record links to 7 conditions, with Acute Myeloid Leukemia appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.
NCT04537871 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04537871 about?
NCT04537871 is a clinical study titled "Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study". This study evaluates how well the heart, lungs, and muscles are working individually, and how these systems are working together in transplant survivors. Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for develop...
What is the current status of trial NCT04537871?
This trial is currently active not recruiting. The enrollment target is 350 participants. The study started on 2020-11-18. Estimated completion is 2026-06-30.
What conditions does trial NCT04537871 study?
This clinical trial studies the following conditions: Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, Non-Hodgkin Lymphoma, Hematopoietic and Lymphoid Cell Neoplasm.
What interventions are being tested in trial NCT04537871?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Echocardiography (PROCEDURE), Bioelectric Impedance Analysis (PROCEDURE), Cardiopulmonary Exercise Testing (PROCEDURE), Physical Performance Testing (PROCEDURE).
Who is sponsoring clinical trial NCT04537871?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04537871 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04537871's enrollment target sits among peer trials
350 16th of 306 higher than 291 of 306 other Acute Myeloid Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Myeloid Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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