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ClinicalTrials.gov 58 recruiting now official registry

Acute Lymphoblastic Leukemia clinical trials

58 of 132 indexed Acute Lymphoblastic Leukemia trials are currently recruiting.

132 US clinical trials · 58 currently recruiting

Acute Lymphoblastic Leukemia is the subject of 132 registered US clinical trials on ClinicalTrials.gov, 58 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 97 in Phase 1-2 (earlier-stage). The most active sponsor is City of Hope Medical Center, running 15 of these trials.

The research picture

Acute Lymphoblastic Leukemia has 132 registered US clinical trials, 58 of them open to new participants right now, about 44% of the total.

58
recruiting participants now
44%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
15
top sponsor: City of Hope Medical Center
Phase 149Phase 248Phase 37Phase 41

Active & Recent Trials

132 total, page 3 of 3

ACTIVE NOT RECRUITING Phase 1 16 participants

Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant

M.D. Anderson Cancer Center

NCT03622788

ACTIVE NOT RECRUITING Phase 1 15 participants

Administration of Donor T Cells With the Caspase-9 Suicide Gene

Baylor College of Medicine

NCT01494103

ACTIVE NOT RECRUITING Early Phase 1 12 participants

A Study of Venetoclax in Combination With Chemotherapy to Treat Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)

Memorial Sloan Kettering Cancer Center

NCT05386576

ACTIVE NOT RECRUITING Phase 1 12 participants

Adding Ruxolitinib to a Combination of Dasatinib Plus Dexamethasone in Remission Induction Therapy in Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Patients Aged 40 Years or Older

Memorial Sloan Kettering Cancer Center

NCT02494882

ACTIVE NOT RECRUITING Phase 1 10 participants

CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene

Baylor College of Medicine

NCT00710892

ACTIVE NOT RECRUITING Phase 2 7 participants

Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

City of Hope Medical Center

NCT04060277

ACTIVE NOT RECRUITING Phase 1 7 participants

90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome

City of Hope Medical Center

NCT05139004

COMPLETED Phase 3 5,377 participants

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Children's Oncology Group

NCT00103285

COMPLETED 301 participants

Cancer Care Delivery in Adolescent and Young Adult Patients With Acute Lymphoblastic Leukemia

Children's Oncology Group

NCT03204916

COMPLETED Phase 2 293 participants

An Extension Study to Determine the Safety and Anti-Leukemic Effects of Imatinib Mesylate in Adult Participants With Ph+ Leukemia

Novartis Pharmaceuticals

NCT00171249

COMPLETED Phase 2 202 participants

Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow

National Heart, Lung, and Blood Institute (NHLBI)

NCT00003838

COMPLETED Phase 1 134 participants

Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Malignancies

National Cancer Institute (NCI)

NCT02315612

COMPLETED 119 participants

Collect and Assess Tissue Samples From Subjects With Hematologic Malignancy

Notable Labs

NCT04014764

COMPLETED Phase 2 107 participants

Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia.

M.D. Anderson Cancer Center

NCT00390793

COMPLETED Phase 1 93 participants

Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia

Amgen Research (Munich)

NCT01471782

COMPLETED Phase 2 73 participants

Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer

Fred Hutchinson Cancer Center

NCT00723099

COMPLETED Phase 2 63 participants

Rapamycin for Immunosuppression and B Cell Modulation Post Stem Cell Transplant for Acute Lymphoblastic Leukemia (ALL)

University of Utah

NCT00795886

COMPLETED Phase 1 52 participants

ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies

AbbVie (prior sponsor, Abbott)

NCT01110473

COMPLETED Phase 2 51 participants

Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL)

St. Jude Children's Research Hospital

NCT01506453

COMPLETED Phase 2 47 participants

Intensified Post Remission Therapy Containing PEG-Asparaginase

University of Southern California

NCT00184041

COMPLETED Phase 2 46 participants

T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts

Baylor College of Medicine

NCT00368355

COMPLETED Phase 1 45 participants

Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Chemotherapy for Leukemia

Cellerant Therapeutics

NCT01297543

COMPLETED Phase 1 43 participants

Improving Blood Stem Cell Collection and Transplant Procedures

National Heart, Lung, and Blood Institute (NHLBI)

NCT01517035

COMPLETED NA 40 participants

Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

University of Virginia

NCT04629430

COMPLETED Phase 2 30 participants

Sirolimus With Tacrolimus for Graft-vs-Host Disease Prophylaxis After Un-Related Stem Cell Transplantation

Dana-Farber Cancer Institute

NCT00144677

COMPLETED 15 participants

Long-Term Follow-up Study for Patients Previously Treated With JCAR015

Juno Therapeutics, a Subsidiary of Celgene

NCT02813252

COMPLETED Phase 2 11 participants

Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia

H. Lee Moffitt Cancer Center and Research Institute

NCT03575325

COMPLETED Phase 2 8 participants

Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplant

Andrew Rezvani

NCT03267186

COMPLETED Phase 2 7 participants

CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML

Robert Lowsky

NCT04151706

COMPLETED Early Phase 1 7 participants

A Pilot Study to Determine the Safety and Tolerability of Sirolimus Given With Hyper-CVAD Chemotherapy

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT01184885

COMPLETED Phase 1 7 participants

Personalized Kinase Inhibitor Therapy Combined With Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia

OHSU Knight Cancer Institute

NCT02779283

COMPLETED Phase 1 6 participants

TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia

TCR2 Therapeutics

NCT04323657

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Phase Distribution

PhaseTrial count
Phase 1 49
Phase 2 48
Phase 3 7
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Lymphoblastic Leukemia Trial Landscape

132 indexed Acute Lymphoblastic Leukemia studies · 58 recruiting (44%).

Phase mix: 8 late (III/IV) vs 97 early (I/II).

Top sponsor: City of Hope Medical Center (15 trials), 9 others listed. 32 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Lymphoblastic Leukemia?

PlainTrial tracks 132 US clinical trials for Acute Lymphoblastic Leukemia, of which 58 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Lymphoblastic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.