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NCT03114865 · ClinicalTrials.gov registry record · Phase 1
A Study of Blinatumomab in Patients With Pre B-cell ALL and B-cell NHL as Post-allo-HSCT Remission Maintenance
A Phase 1 study of Acute Lymphoblastic Leukemia and B-Cell Non-Hodgkin Lymphoma, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- Active
- Registry status
- Phase 1
- Development phase
- 44
- Enrollment target
- 1
- Study location
NCT03114865: Active Phase 1 study of Acute Lymphoblastic Leukemia and B-Cell Non-Hodgkin Lymphoma, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
NCT03114865 is a Phase 1 study of Acute Lymphoblastic Leukemia and B-Cell Non-Hodgkin Lymphoma that is active but no longer recruiting, run by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. The registered enrollment target is 44 participants, below the 382-participant average among 131 other Acute Lymphoblastic Leukemia trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03114865, a Phase 1 study of Acute Lymphoblastic Leukemia and B-Cell Non-Hodgkin Lymphoma, is active but no longer recruiting, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 44 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators primary objective is to determine the safety and toxicity of incorporating blinatumomab into the post-allogeneic hematopoietic stem cell transplant (HSCT) maintenance setting for patients with CD19+-B-cell malignancies (Acute Lymphoblastic Leukemia \[ALL\], Non-Hodgkin's Lymphoma \[NHL\]).
Primary Outcome
Percentage of enrolled participants who receive BMT and Blinatumomab and are alive at two years post BMT.
Conditions Studied
Interventions
- DRUG Dexamethasone
- DRUG Blinatumomab
- DRUG Blinatumomab 9ug
- DRUG Blinatumomab 28 ug
Study Locations (1)
Maryland
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 44 participants |
| Start Date | 2017-09-05 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 1 |
What the registry record for NCT03114865 still lists
NCT03114865 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 44 participants, a relatively small participant target, below the 382-participant average among 131 other Acute Lymphoblastic Leukemia trials with a reported enrollment target (88% lower).
The record links to 3 conditions, with Acute Lymphoblastic Leukemia appearing as the primary indexed condition, and to 4 interventions - of which Dexamethasone is the first listed.
NCT03114865 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT03114865 about?
NCT03114865 is a clinical study titled "A Study of Blinatumomab in Patients With Pre B-cell ALL and B-cell NHL as Post-allo-HSCT Remission Maintenance". The investigators primary objective is to determine the safety and toxicity of incorporating blinatumomab into the post-allogeneic hematopoietic stem cell transplant (HSCT) maintenance setting for patients with CD19+-B-cell malignancies (Acute Lymphoblastic Leukemia \[ALL\], Non-Hodgkin's Lymphoma \...
What is the current status of trial NCT03114865?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 44 participants. The study started on 2017-09-05. Estimated completion is 2026-06-30.
What conditions does trial NCT03114865 study?
This clinical trial studies the following conditions: Acute Lymphoblastic Leukemia, B-Cell Non-Hodgkin Lymphoma, Pre B-Cell Acute Lymphoblastic Leukaemia.
What interventions are being tested in trial NCT03114865?
The interventions under investigation include: Dexamethasone (DRUG), Blinatumomab (DRUG), Blinatumomab 9ug (DRUG), Blinatumomab 28 ug (DRUG).
Who is sponsoring clinical trial NCT03114865?
This trial is sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, which has 523 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03114865 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Lymphoblastic Leukemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03114865's enrollment target sits among peer trials
44 79th of 131 higher than 53 of 131 other Acute Lymphoblastic Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Lymphoblastic Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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