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ACTIVE NOT RECRUITING Phase 2

MT2017-45: CAR-T Cell Therapy for Heme Malignancies

NCT03642626 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase II study of FDA-approved CAR-T products for patients with hematologic malignancies. Patients will be assigned to Arm A and B based on age and diagnosis. Overall remission rate, safety events and other endpoints will be calculated for Arm A and B separately.

Interventions

  • DRUG KYMRIAH
  • DRUG YESCARTA
  • DRUG Fludarabine 30mg/m2 4 doses
  • DRUG Cyclophosphamide 500 mg/m2; 2 doses
  • DRUG Fludarabine 30mg/m2 3 doses

Study Locations (1)

Minnesota

  • Masonic Cancer Center at University of Minnesota — Minneapolis

Trial Details

FieldValue
Enrollment Target 150 participants
Start Date 2018-12-18
Est. Completion 2028-06-01
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03642626

The ClinicalTrials.gov registry entry for NCT03642626 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Masonic Cancer Center, University of Minnesota, which has 154 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Acute Lymphoblastic Leukemia appearing as the primary indexed condition, and to 5 interventions — of which KYMRIAH is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03642626 reports 1 study location spanning 1 distinct geographic area — top geographies include Minnesota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03642626 about?

NCT03642626 is a clinical study titled "MT2017-45: CAR-T Cell Therapy for Heme Malignancies". This is a phase II study of FDA-approved CAR-T products for patients with hematologic malignancies. Patients will be assigned to Arm A and B based on age and diagnosis. Overall remission rate, safety events and other endpoints will be calculated for Arm A and B separately.

What is the current status of trial NCT03642626?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 150 participants. The study started on 2018-12-18. Estimated completion is 2028-06-01.

What conditions does trial NCT03642626 study?

This clinical trial studies the following conditions: Acute Lymphoblastic Leukemia, Large B-cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03642626?

The interventions under investigation include: KYMRIAH (DRUG), YESCARTA (DRUG), Fludarabine 30mg/m2 4 doses (DRUG), Cyclophosphamide 500 mg/m2; 2 doses (DRUG), Fludarabine 30mg/m2 3 doses (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03642626?

This trial is sponsored by Masonic Cancer Center, University of Minnesota, which has 154 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03642626 being conducted?

This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial