Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia

NCT00792948 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial is studying the side effects of giving combination chemotherapy together with or without donor stem cell transplant and to see how well it works in treating patients with acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect).

Interventions

  • DRUG Cyclophosphamide
  • DRUG Dexamethasone
  • DRUG Cytarabine
  • DRUG Dasatinib
  • PROCEDURE Allogeneic Hematopoietic Stem Cell Transplantation

Study Locations (20)

Illinois

  • MacNeal Hospital and Cancer Center — Berwyn
  • Hematology and Oncology Associates — Chicago
  • Northwestern University — Chicago
  • University of Chicago Comprehensive Cancer Center — Chicago
  • Hematology Oncology Associates of Illinois-Highland Park — Highland Park
  • Presence Saint Mary's Hospital — Kankakee
  • AMG Libertyville - Oncology — Libertyville
  • Loyola University Medical Center — Maywood
  • DuPage Medical Group-Ogden — Naperville
  • Illinois Cancer Specialists-Niles — Niles
  • Hematology Oncology Associates of Illinois - Skokie — Skokie
  • Springfield Memorial Hospital — Springfield

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • Stanford Cancer Institute Palo Alto — Palo Alto
  • University of California Davis Comprehensive Cancer Center — Sacramento

Arizona

  • Banner University Medical Center - Tucson — Tucson
  • University of Arizona Cancer Center-North Campus — Tucson

Florida

  • UF Health Cancer Institute - Gainesville — Gainesville
  • AdventHealth Orlando — Orlando

Georgia

  • Emory University Hospital/Winship Cancer Institute — Atlanta

Trial Details

FieldValue
Enrollment Target 97 participants
Start Date 2009-09-01
Est. Completion 2027-01-06
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00792948

The ClinicalTrials.gov registry entry for NCT00792948 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 97 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 7 conditions, with Acute Lymphoblastic Leukemia appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00792948 reports 20 study locations spanning 5 distinct geographic areas — top geographies include Illinois, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00792948 about?

NCT00792948 is a clinical study titled "Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia". This phase II trial is studying the side effects of giving combination chemotherapy together with or without donor stem cell transplant and to see how well it works in treating patients with acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer ...

What is the current status of trial NCT00792948?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 97 participants. The study started on 2009-09-01. Estimated completion is 2027-01-06.

What conditions does trial NCT00792948 study?

This clinical trial studies the following conditions: Acute Lymphoblastic Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia, Adult T Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00792948?

The interventions under investigation include: Cyclophosphamide (DRUG), Dexamethasone (DRUG), Cytarabine (DRUG), Dasatinib (DRUG), Allogeneic Hematopoietic Stem Cell Transplantation (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00792948?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00792948 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial