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NCT04105530 · ClinicalTrials.gov registry record · NA
Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)
A NA study of Acute Lymphoblastic Leukemia and Executive Dysfunction, sponsored by St. Jude Children's Research Hospital.
- Active
- Registry status
- NA
- Development phase
- 36
- Enrollment target
- 1
- Study location
NCT04105530 is a NA study of Acute Lymphoblastic Leukemia and Executive Dysfunction that is active but no longer recruiting, run by St. Jude Children's Research Hospital. The registered enrollment target is 36 participants, below the 382-participant average among 131 other Acute Lymphoblastic Leukemia trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04105530, a NA study of Acute Lymphoblastic Leukemia and Executive Dysfunction, is active but no longer recruiting, sponsored by St. Jude Children's Research Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 36 participants
- Enrollment target
- 1
- Study location
Study Summary
Brief Overview: Children and adolescents diagnosed with cancer will experience problems with learning, memory and attention during and after completing their cancer therapy. There are many factors that contribute to this problem, but investigators have recently identified that chemotherapy agents used in treating Acute Lymphoblastic Leukemia (ALL) may disrupt normal brain development. A novel device has been developed that may help correct this disruption. Direct Current Stimulation (DCS) uses a very low level of constant electrical current to stimulate specific parts of the brain. It has been used in patients with stroke to great benefit. Our study at St. Jude Children's Research Hospital is designed to see if this technique will benefit survivors of childhood cancer. Specifically, investigators wish to see if stimulating one part of the brain gives a greater benefit than stimulating another part of the brain. Primary Objective Evaluate the feasibility of conducting repeated on-site Transcranial Direct Current Stimulation (tDCS) in children who are long-term survivors of Secondary Objectives * To estimate the potential efficacy for powering a future larger study using tDCS to improve cognitive performance in children by suppressing over connected neural hubs in long-term survivors of childhood ALL. * To compare the performance of anodal stimulation of the frontal lobe to cathodal suppression of the superior temporal lobe on cognitive performance.
Conditions Studied
Interventions
- DEVICE Sham treatment
- DEVICE Anodal tDCS treatment
- DEVICE Cathodal tDCS treatment
- OTHER NIH Toolbox List Sorting Working Memory Test
- OTHER NIH Toolbox Flanker Inhibitory Control and Attention Test
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2019-11-18 |
| Est. Completion | 2024-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04105530
The ClinicalTrials.gov registry entry for NCT04105530 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 36 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 382-participant average among 131 other Acute Lymphoblastic Leukemia trials with a reported enrollment target (91% lower). The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Acute Lymphoblastic Leukemia appearing as the primary indexed condition, and to 5 interventions - of which Sham treatment is the first listed.
NCT04105530 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT04105530 about?
NCT04105530 is a clinical study titled "Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)". Brief Overview: Children and adolescents diagnosed with cancer will experience problems with learning, memory and attention during and after completing their cancer therapy. There are many factors that contribute to this problem, but investigators have recently identified that chemotherapy agents us...
What is the current status of trial NCT04105530?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 36 participants. The study started on 2019-11-18. Estimated completion is 2024-09.
What conditions does trial NCT04105530 study?
This clinical trial studies the following conditions: Acute Lymphoblastic Leukemia, Executive Dysfunction, Transcranial Direct Current Stimulation.
What interventions are being tested in trial NCT04105530?
The interventions under investigation include: Sham treatment (DEVICE), Anodal tDCS treatment (DEVICE), Cathodal tDCS treatment (DEVICE), NIH Toolbox List Sorting Working Memory Test (OTHER), NIH Toolbox Flanker Inhibitory Control and Attention Test (OTHER).
Who is sponsoring clinical trial NCT04105530?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04105530 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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