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NCT05582200 · ClinicalTrials.gov registry record
Selective PET Imaging of Astrocytes and Microglia in Alzheimer's Disease
A clinical trial, sponsored by The Methodist Hospital Research Institute.
- Recruiting
- Registry status
- 71
- Enrollment target
NCT05582200 is a clinical trial that is actively recruiting participants, run by The Methodist Hospital Research Institute. The registered enrollment target is 71 participants.
The verdict
NCT05582200 is actively recruiting participants, sponsored by The Methodist Hospital Research Institute.
- RECRUITING
- Registry status
- 71 participants
- Enrollment target
Study Summary
Inflammation occurs in many brain diseases including Alzheimer's disease. In Alzheimer's disease, an abnormal protein called amyloid starts accumulating decades before the start of forgetfulness. However, scientists have reported that inflammation but not amyloid is linked to forgetfulness and the topography of brain inflammation and tau buildup are closely correlated in patients with mild cognitive impairment due to Alzheimer's disease. New medications are under development to help healing and prevent permanent damage in the brain. To see if inflammation is improving or getting worse with these medications, investigators can watch inside of the brain using a special camera called positron emission tomography (PET). It is currently possible to watch inflammation in the brain by taking pictures of a molecule called translocator protein (TSPO). But the problem is that by imaging TSPO, investigators can catch changes in more than one kind of cells. The information is not specific to each cell type. Such vague information is not completely useful to monitor the effect of new medications for inflammation. This proposal attempts to develop a novel method to capture changes in each of two major players in inflammation, microglia and astrocytes. To do so, investigators will take selective pictures of one cell type by using a novel imaging agent for PET. Investigators will also take PET pictures of TSPO. Investigators will process these two kinds of PET pictures using advanced mathematical methods and extract specific information on microglia and astrocytes. Our novel method will be useful to monitor new therapies to treat inflammation in the brain.
Interventions
- DRUG Positron Emission Tomography (PET) using 11C-ER176 for TSPO and 18F-SMBT1 for MAO-B
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 71 participants |
| Start Date | 2023-01-20 |
| Est. Completion | 2028-10-31 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05582200
The ClinicalTrials.gov registry entry for NCT05582200 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 71 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is The Methodist Hospital Research Institute, which has 126 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Positron Emission Tomography (PET) using 11C-ER176 for TSPO and 18F-SMBT1 for MAO-B is the first listed.
NCT05582200 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05582200 about?
NCT05582200 is a clinical study titled "Selective PET Imaging of Astrocytes and Microglia in Alzheimer's Disease". Inflammation occurs in many brain diseases including Alzheimer's disease. In Alzheimer's disease, an abnormal protein called amyloid starts accumulating decades before the start of forgetfulness. However, scientists have reported that inflammation but not amyloid is linked to forgetfulness and the t...
What is the current status of trial NCT05582200?
This trial is currently recruiting. The enrollment target is 71 participants. The study started on 2023-01-20. Estimated completion is 2028-10-31.
What interventions are being tested in trial NCT05582200?
The interventions under investigation include: Positron Emission Tomography (PET) using 11C-ER176 for TSPO and 18F-SMBT1 for MAO-B (DRUG).
Who is sponsoring clinical trial NCT05582200?
This trial is sponsored by The Methodist Hospital Research Institute, which has 126 total clinical trials registered on ClinicalTrials.gov.
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