Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06381791 · ClinicalTrials.gov registry record · Phase 1
CBD for Pain Following Orthopedic Shoulder Surgery
A Phase 1 study of Rotator Cuff Injuries and Shoulder Osteoarthritis, sponsored by The Methodist Hospital Research Institute.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT06381791: Recruiting Phase 1 study of Rotator Cuff Injuries and Shoulder Osteoarthritis, sponsored by The Methodist Hospital Research Institute.
NCT06381791 is a Phase 1 study of Rotator Cuff Injuries and Shoulder Osteoarthritis that is actively recruiting participants, run by The Methodist Hospital Research Institute. The registered enrollment target is 80 participants, below the 93-participant average among 10 other Rotator Cuff Injuries trials with a reported enrollment target (14% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06381791, a Phase 1 study of Rotator Cuff Injuries and Shoulder Osteoarthritis, is actively recruiting participants, sponsored by The Methodist Hospital Research Institute.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of the study is to learn if Epidiolex (cannabidiol) works as a additional pain medication in patients who have had orthopedic shoulder surgery. It is also to learn about safe dosages and identify any side effects after surgery. Researchers will compare Epidiolex to a placebo solution to see if Epidiolex lowers pain after shoulder surgery. Participants will: * track their pain and what medications they use every day in a provided pain diary. A researchers will call every seven days to check on the participant and diary. * Complete two short surveys. Once before surgery and once after. * Have bloodwork tested after surgery
Primary Outcome
Evaluation of postoperative pain journal responses from subjects. The pain diary will track their pain level on a Visual Analogue Scale (VAS) and their documented pain medication usage.
Conditions Studied
Interventions
- DRUG Epidiolex
- DRUG Placebo oral solution
Study Locations (1)
Texas
- Houston Methodist Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2024-05-24 |
| Est. Completion | 2027-12-30 |
| Phase | Phase 1 |
What NCT06381791 shows while recruiting
NCT06381791 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 93-participant average among 10 other Rotator Cuff Injuries trials with a reported enrollment target (14% lower).
The record links to 2 conditions, with Rotator Cuff Injuries appearing as the primary indexed condition, and to 2 interventions - of which Epidiolex is the first listed.
NCT06381791 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06381791 about?
NCT06381791 is a clinical study titled "CBD for Pain Following Orthopedic Shoulder Surgery". The goal of the study is to learn if Epidiolex (cannabidiol) works as a additional pain medication in patients who have had orthopedic shoulder surgery. It is also to learn about safe dosages and identify any side effects after surgery. Researchers will compare Epidiolex to a placebo solution to se...
What is the current status of trial NCT06381791?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 80 participants. The study started on 2024-05-24. Estimated completion is 2027-12-30.
What conditions does trial NCT06381791 study?
This clinical trial studies the following conditions: Rotator Cuff Injuries, Shoulder Osteoarthritis.
What interventions are being tested in trial NCT06381791?
The interventions under investigation include: Epidiolex (DRUG), Placebo oral solution (DRUG).
Who is sponsoring clinical trial NCT06381791?
This trial is sponsored by The Methodist Hospital Research Institute, which has 126 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06381791 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Rotator Cuff Injuries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06381791's enrollment target sits among peer trials
80 5th of 10 higher than 5 of 10 other Rotator Cuff Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Rotator Cuff Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Shoulder RFA Pilot Study
RECRUITING
-
Subscap Reverse Shoulder Arthroplasty
RECRUITING · NA
-
The Effect of a Custom Pillow on Sleep Quality in Patients With Nonoperative Rotator Cuff Syndrome
RECRUITING · NA
-
Therapeutic Exercise for Rotator Cuff Tendinopathy / Subacromial Pain Syndrome - Outcomes and Mechanisms
RECRUITING · NA
-
Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block
RECRUITING
-
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01243931 · 80 participants · NA
Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
- NCT01659203 · 80 participants · Phase 1
Proton or Photon RT for Retroperitoneal Sarcomas
- NCT01803451 · 80 participants · Early Phase 1
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
- NCT01964859 · 80 participants · Phase 2
Feasibility Study for Fibroblast Autologous Skin Grafts
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI