St. Jude Children's Research Hospital

410 total trials 90 currently recruiting 227 completed

St. Jude Children's Research Hospital sponsors 410 registered US clinical trials on ClinicalTrials.gov, 90 of them currently recruiting, and 227 completed. 19 of these trials are in Phase 3-4 (later-stage) and 173 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Sickle Cell Disease, with 17 trials.

Trial Pipeline

410 total, page 3 of 9

ACTIVE NOT RECRUITING

Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients

NCT05164016

ACTIVE NOT RECRUITING Phase 2

An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer

NCT04733534

ACTIVE NOT RECRUITING Phase 2

An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer

NCT04742751

ACTIVE NOT RECRUITING Phase 1

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

NCT04898894

ACTIVE NOT RECRUITING Phase 1

Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)

NCT03597594

ACTIVE NOT RECRUITING Phase 1

Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis

NCT04551131

ACTIVE NOT RECRUITING NA

Telehealth Based Intervention to Improve Functional Capacity in Survivors of Childhood Cancer With Significantly Limited Exercise Tolerance

NCT04714840

ACTIVE NOT RECRUITING

Social Experiences of Adolescents and Young Adults With Cancer

NCT04328350

ACTIVE NOT RECRUITING

Estimating Setup Uncertainty in Pediatric Proton Therapy Using Volumetric Images

NCT04125095

ACTIVE NOT RECRUITING

Patient-Reported Outcome Version of the Common Criteria for Adverse Events

NCT04050072

ACTIVE NOT RECRUITING NA

Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)

NCT04105530

ACTIVE NOT RECRUITING Early Phase 1

18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma

NCT03541720

ACTIVE NOT RECRUITING

Exploring Adherence Monitoring in Sickle Cell Disease

NCT03708731

ACTIVE NOT RECRUITING Phase 2

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

NCT03849651

ACTIVE NOT RECRUITING Phase 2

Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

NCT03755804

ACTIVE NOT RECRUITING Phase 1

Evaluation of CD19-Specific CAR Engineered Autologous T-Cells for Treatment of Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia

NCT03573700

ACTIVE NOT RECRUITING

Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation

NCT03361020

ACTIVE NOT RECRUITING

Next Generation Pathogen Sequencing for Prediction of Adverse Events

NCT03226158

ACTIVE NOT RECRUITING

Evaluation of Proton Therapy in Pediatric Cancer Patients

NCT03223766

ACTIVE NOT RECRUITING

Social Emotional Development in Young Children With Cancer

NCT03086421

ACTIVE NOT RECRUITING Phase 2

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

NCT03164057

ACTIVE NOT RECRUITING Phase 2

Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

NCT03117751

ACTIVE NOT RECRUITING Phase 2

Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

NCT02790515

ACTIVE NOT RECRUITING Phase 2

A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection

NCT02792582

ACTIVE NOT RECRUITING Phase 1

Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I

NCT02553460

ACTIVE NOT RECRUITING

A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer

NCT02256137

ACTIVE NOT RECRUITING Phase 2

Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors

NCT02114229

ACTIVE NOT RECRUITING Phase 2

A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma

NCT02125786

ACTIVE NOT RECRUITING Phase 2

Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors

NCT01946529

ACTIVE NOT RECRUITING Phase 2

Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy

NCT01871766

ACTIVE NOT RECRUITING Phase 2

Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma

NCT01920932

ACTIVE NOT RECRUITING Phase 2

Therapy for Children With Advanced Stage Neuroblastoma

NCT01857934

ACTIVE NOT RECRUITING Phase 2

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

NCT01878617

ACTIVE NOT RECRUITING Phase 2

Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

NCT01783535

ACTIVE NOT RECRUITING Phase 2

A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection

NCT01419067

ACTIVE NOT RECRUITING Phase 2

Mature B-Cell Lymphoma And Leukemia Study III

NCT01046825

ACTIVE NOT RECRUITING Phase 1

Dose-Escalation Study Of A Self Complementary Adeno-Associated Viral Vector For Gene Transfer in Hemophilia B

NCT00979238

ACTIVE NOT RECRUITING Phase 2

Methionine PET/CT Studies In Patients With Cancer

NCT00840047

ACTIVE NOT RECRUITING

Stress, Adjustment And Growth In Children With Cancer And Their Parents

NCT01044160

ACTIVE NOT RECRUITING Phase 2

Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Favorable-Risk Hodgkin Lymphoma

NCT00846742

ACTIVE NOT RECRUITING Phase 2

Phase II Study Incorporating Pegylated Interferon In the Treatment For Children With High-Risk Melanoma

NCT00539591

ACTIVE NOT RECRUITING Phase 2

Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma

NCT00602667

ACTIVE NOT RECRUITING Phase 2

Radiation Therapy to Treat Musculoskeletal Tumors

NCT00186992

NOT YET RECRUITING

Muscle Aging Phenotypes in Childhood Cancer Survivors

NCT07531498

NOT YET RECRUITING Phase 2

Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease

NCT07616154

NOT YET RECRUITING NA

Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

NCT07514819

NOT YET RECRUITING

Real World Asparaginase Therapy Toxicity

NCT07008027

NOT YET RECRUITING

Insights From Bereaved Parents and Oncologists

NCT07663539

NOT YET RECRUITING

Liver Biopsy Following Gene Therapy For Hemophilia

NCT05932914

NOT YET RECRUITING

Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE

NCT07594392

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 86
Phase 3 17
Phase 4 2

What the Pipeline for St. Jude Children's Research Hospital Shows

According to the ClinicalTrials.gov registry, St. Jude Children's Research Hospital is linked to 410 US clinical trials across every stage of research activity. Of those, 90 studies are currently recruiting, about 22% of the sponsor's indexed portfolio, and 227 are already marked complete, representing roughly 55% of the total.

The phase mix for St. Jude Children's Research Hospital reports 19 late-stage studies (Phase 3 and Phase 4 combined) and 173 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for St. Jude Children's Research Hospital is Sickle Cell Disease with 17 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.