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NCT07531498 · ClinicalTrials.gov registry record
Muscle Aging Phenotypes in Childhood Cancer Survivors
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Not yet
- Registry status
- 533
- Enrollment target
NCT07531498 is a clinical trial that has not yet begun recruiting, run by St. Jude Children's Research Hospital. The registered enrollment target is 533 participants.
The verdict
NCT07531498 has not yet begun recruiting, sponsored by St. Jude Children's Research Hospital.
- NOT YET RECRUITING
- Registry status
- 533 participants
- Enrollment target
Study Summary
Childhood cancer survivors experience premature declines in muscle mass, strength, and physical function that contribute to morbidity and early mortality. The biological mechanisms driving these impairments are heterogeneous and poorly understood. This observational study aims to characterize distinct muscle health endotypes in adult survivors of childhood cancer using advanced imaging, neuromuscular testing, and functional assessment. Survivors with reduced muscle health and community controls will undergo multimodal magnetic resonance imaging and spectroscopy, nerve conduction studies, surface electromyography, body composition assessment, and physical performance testing during a single study visit integrated into an ongoing cohort evaluation. Identifying mechanistic endotypes of impaired muscle health will support development of targeted interventions to preserve function and improve long-term outcomes in childhood cancer survivors. Primary Objective: \- Characterize reduced muscle health endotypes in childhood cancer survivors. Secondary Objective: \- Identify specific treatment and lifestyle related risk factors for each reduced muscle health endotype. Exploratory Objective: \- Host germline genetics will be associated with specific muscle endotypes.
Interventions
- OTHER Multimodal Muscle Imaging and Functional Assessment
- OTHER Multimodal Muscle Imaging and Neuromuscular Assessment
- OTHER Comprehensive Muscle Phenotyping
- OTHER Integrated Neuromuscular and Imaging Evaluation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 533 participants |
| Start Date | 2026-10-01 |
| Est. Completion | 2031-05 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07531498
The ClinicalTrials.gov registry entry for NCT07531498 describes a study currently listed as not yet recruiting, categorized as an unspecified phase. The registered enrollment target is 533 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Multimodal Muscle Imaging and Functional Assessment is the first listed.
NCT07531498 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07531498 about?
NCT07531498 is a clinical study titled "Muscle Aging Phenotypes in Childhood Cancer Survivors". Childhood cancer survivors experience premature declines in muscle mass, strength, and physical function that contribute to morbidity and early mortality. The biological mechanisms driving these impairments are heterogeneous and poorly understood. This observational study aims to characterize distin...
What is the current status of trial NCT07531498?
This trial is currently not yet recruiting. The enrollment target is 533 participants. The study started on 2026-10-01. Estimated completion is 2031-05.
What interventions are being tested in trial NCT07531498?
The interventions under investigation include: Multimodal Muscle Imaging and Functional Assessment (OTHER), Multimodal Muscle Imaging and Neuromuscular Assessment (OTHER), Comprehensive Muscle Phenotyping (OTHER), Integrated Neuromuscular and Imaging Evaluation (OTHER).
Who is sponsoring clinical trial NCT07531498?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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