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NCT07594392 · ClinicalTrials.gov registry record
Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Not yet
- Registry status
- 650
- Enrollment target
NCT07594392: Clinical Trial study, sponsored by St. Jude Children's Research Hospital.
NCT07594392 is a clinical trial that has not yet begun recruiting, run by St. Jude Children's Research Hospital. The registered enrollment target is 650 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07594392 has not yet begun recruiting, sponsored by St. Jude Children's Research Hospital.
- NOT YET RECRUITING
- Registry status
- 650 participants
- Enrollment target
Study Summary
Childhood cancer survivors are at increased risk for premature atherosclerotic cardiovascular disease (ASCVD) due to cancer treatment-related exposures, including radiation therapy and platinum-based chemotherapy. Current ASCVD risk assessment tools may underestimate cardiovascular risk in younger survivors. This observational study performs detailed cardiovascular phenotyping using imaging, blood-based biomarkers, and vascular function testing among adult survivors enrolled in the St. Jude Lifetime Cohort (SJLIFE), with comparison to community controls, to better characterize subclinical ASCVD risk and inform survivor-specific prevention strategies. Primary Objective: Perform deeper phenotyping of SJLIFE participants at treatment-related risk of atherosclerotic cardiovascular disease \[ASCVD\] to facilitate early detection of pathophysiological targets appropriate for remediation. Secondary Objectives: Determine the distribution of lipoprotein (a) levels and prevalence of elevated levels among survivors with any treatment related exposure-based risk for ASCVD overall and then compared to community controls. Evaluate prevalence of clinical and imaging markers of ASCVD risk among survivors exposed only to platinum chemotherapy and compare that to community controls.
Primary Outcome
Coronary artery calcium (CAC) score (Agatston score) reported as a whole number and then categorized as abnormal first as CAC\>0 and then as CAC\>100.
Interventions
- DIAGNOSTIC_TEST Coronary Artery Calcium Scan
- DIAGNOSTIC_TEST Carotid Artery Ultrasound
- DIAGNOSTIC_TEST Lipoprotein(a) Measurement
- DIAGNOSTIC_TEST Vascular Function Testing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 650 participants |
| Start Date | 2026-06 |
| Est. Completion | 2031-06 |
What is known before NCT07594392 opens enrollment
NCT07594392 is an observational study that tracks outcomes without assigning an intervention. The registered 650 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 4 interventions - of which Coronary Artery Calcium Scan is the first listed.
NCT07594392 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07594392 about?
NCT07594392 is a clinical study titled "Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE". Childhood cancer survivors are at increased risk for premature atherosclerotic cardiovascular disease (ASCVD) due to cancer treatment-related exposures, including radiation therapy and platinum-based chemotherapy. Current ASCVD risk assessment tools may underestimate cardiovascular risk in younger s...
What is the current status of trial NCT07594392?
This trial is currently not yet recruiting. The enrollment target is 650 participants. The study started on 2026-06. Estimated completion is 2031-06.
What interventions are being tested in trial NCT07594392?
The interventions under investigation include: Coronary Artery Calcium Scan (DIAGNOSTIC_TEST), Carotid Artery Ultrasound (DIAGNOSTIC_TEST), Lipoprotein(a) Measurement (DIAGNOSTIC_TEST), Vascular Function Testing (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07594392?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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