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ClinicalTrials.gov 37 recruiting now official registry

Hematologic Malignancy clinical trials

Every US clinical trial registered for Hematologic Malignancy — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

49 US clinical trials · 37 currently recruiting

The research picture

Hematologic Malignancy has 49 registered US clinical trials, 37 of them open to new participants right now — about 76% of the total.

37
recruiting participants now
76%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
6
top sponsor: St. Jude Children's Research Hospital

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 5,000 participants

Global Cardio Oncology Registry

The Cleveland Clinic

NCT05598879

RECRUITING 1,500 participants

Immune Profiling for Cancer Immunotherapy Response

Dartmouth-Hitchcock Medical Center

NCT06116032

RECRUITING NA 800 participants

BMT-CARE: Psychosocial Intervention for Transplant Caregivers

Massachusetts General Hospital

NCT06472089

RECRUITING NA 700 participants

HEME Home Transfusion Program

Dana-Farber Cancer Institute

NCT06487247

RECRUITING NA 356 participants

Mosaic Trial for Stem Cell Transplant Recipients

Northwestern University

NCT06960993

RECRUITING Phase 1 171 participants

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Kura Oncology

NCT06001788

RECRUITING NA 160 participants

Implementation of an Oral Chemotherapy Adherence Intervention

UNC Lineberger Comprehensive Cancer Center

NCT06989489

RECRUITING NA 160 participants

ONC-MM-2407: The Effect of Virtual Reality Headsets on Pain and Anxiety in the Peri and Post Bone Marrow Biopsy Period

Wake Forest University Health Sciences

NCT07203534

RECRUITING 150 participants

Response to Influenza Vaccination in Pediatric Oncology Patients

St. Jude Children's Research Hospital

NCT05384288

RECRUITING 100 participants

Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

St. Jude Children's Research Hospital

NCT06579469

RECRUITING NA 90 participants

Defining the Role of Palliative carE for Patients With Hematologic Malignancies Undergoing Adoptive CEllular Therapy

Massachusetts General Hospital

NCT05646576

RECRUITING 88 participants

Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant

National Cancer Institute (NCI)

NCT06856226

RECRUITING NA 80 participants

Diet and Cognitive Training in Hematologic Cancer Survivors

University of Alabama at Birmingham

NCT05708716

RECRUITING Phase 2 70 participants

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Masonic Cancer Center, University of Minnesota

NCT05735717

RECRUITING 70 participants

Novel 3D Hematological Malignancy Organoid to Study Disease Biology and Chemosensitivity

Wake Forest University Health Sciences

NCT03890614

RECRUITING NA 66 participants

Intervention for Fatigue in HCT Recipients

Massachusetts General Hospital

NCT05715047

RECRUITING NA 60 participants

Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy

Washington University School of Medicine

NCT06689800

RECRUITING NA 60 participants

Mindfulness Intervention for Sleep Disturbance and Symptom Management in Hematologic Cancer Patients During and After Inpatient Treatment

Duke University

NCT06532773

RECRUITING Phase 1 60 participants

CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma

St. Jude Children's Research Hospital

NCT07257419

RECRUITING Phase 1 54 participants

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

Therapeutic Advances in Childhood Leukemia Consortium

NCT05476770

RECRUITING Phase 3 50 participants

An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

Novartis Pharmaceuticals

NCT06401356

RECRUITING 50 participants

Mechanisms of Disease R/R in CAR-T for Hematologic Malignancies

Duke University

NCT05397132

RECRUITING NA 50 participants

αβT Cell/CD19+ B Cell Depletion for Alternative Donor Allogeneic Hematopoietic Cell Transplantation (HSCT)

Nationwide Children's Hospital

NCT06082947

RECRUITING Phase 2 46 participants

A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant

Memorial Sloan Kettering Cancer Center

NCT07006506

RECRUITING Phase 1 36 participants

Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

Tr1X

NCT06462365

RECRUITING NA 32 participants

A Prospective Study of Conventional Bone Marrow Biopsy Versus Portomar(TM) Biopsy

Aperture Medical Technology

NCT05583734

RECRUITING 30 participants

FDG-PET as an Imaging Modality to Diagnose and Risk Stratify Subclinical, Imaging Negative Ici-Myocarditis

Mayo Clinic

NCT06566209

RECRUITING Phase 1 30 participants

TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies

St. Jude Children's Research Hospital

NCT07052370

RECRUITING 30 participants

Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

Children's Hospital Medical Center, Cincinnati

NCT06131801

RECRUITING Phase 2 30 participants

Phase II Study of Pirtobrutinib With Venetoclax In Relapsed-Refractory MCL (Mantle Cell Lymphoma) Patients

M.D. Anderson Cancer Center

NCT05529069

RECRUITING NA 30 participants

Home Blood Transfusions

Thomas Jefferson University

NCT07121140

RECRUITING Phase 1 20 participants

Trial of Novel Anti-leukemia Agents in Flu/Mel RIC Transplant for Myeloid Malignancies

University of Alabama at Birmingham

NCT07044544

RECRUITING Phase 1 20 participants

Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies

Joshua Sasine, MD, PhD

NCT05887167

RECRUITING 20 participants

Reduced Intensity Fludarabine and TBI Prior to Haplo-Identical Transplantation

Northside Hospital

NCT05417971

RECRUITING Phase 1 18 participants

CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological Malignancies

St. Jude Children's Research Hospital

NCT06326463

RECRUITING Early Phase 1 10 participants

HMCT/CT2401: Abatacept GVHD Prophylaxis Following Omidubicel HCT

Duke University

NCT06731504

RECRUITING Early Phase 1 8 participants

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06398457

ACTIVE NOT RECRUITING NA 120 participants

Mobile CARE-App to Promote Coping for Caregivers of Patients Receiving Stem Cell Transplant

Massachusetts General Hospital

NCT05709912

ACTIVE NOT RECRUITING 100 participants

Technology to Assess Vulnerable Older Adults With Cancer and Their Caregivers

City of Hope Medical Center

NCT02041416

ACTIVE NOT RECRUITING NA 100 participants

Expressive Writing Program Among Young Adults With Blood Cancer

Blood Cancer United

NCT07413991

ACTIVE NOT RECRUITING NA 80 participants

A Positive Psychology Based Intervention (PATH-C) for Caregivers of HSCT Survivors

Brigham and Women's Hospital

NCT06153797

ACTIVE NOT RECRUITING 60 participants

Patient Fitness and Body Composition During Hematopoietic Stem Cell Transplantation

Garcia, Jose M., MD, PhD

NCT02990130

ACTIVE NOT RECRUITING Phase 2 51 participants

Study of Benralizumab in People With Skin Side Effects Caused by Cancer Therapies

Memorial Sloan Kettering Cancer Center

NCT04552288

ACTIVE NOT RECRUITING 21 participants

Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients

St. Jude Children's Research Hospital

NCT05164016

ACTIVE NOT RECRUITING Phase 2 21 participants

Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation

Weill Medical College of Cornell University

NCT04395222

ACTIVE NOT RECRUITING Phase 1 20 participants

Haploidentical Hematopoietic Cell Transplantation for Children With Hematologic Malignancies and Myelodysplasia

Nationwide Children's Hospital

NCT03431090

COMPLETED NA 57 participants

Mindfulness and CBT for Sleep

Duke University

NCT04736056

COMPLETED Phase 2 29 participants

PROACTIVE: Preventing Acute/Chronic GVHD With TocIlizumab Combined With GVHD Prophylaxis Post allogEneic Transplant

Medical College of Wisconsin

NCT03699631

COMPLETED Phase 1 3 participants

Unrelated Cord Blood Transplant Plus a Haplo-Identical (Half-Matched), T-Cell Depleted Stem Transplant From a Related Donor for Subjects With High Risk Malignancies

Joanne Kurtzberg, MD

NCT00673114

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 6
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hematologic Malignancy Trial Landscape

ClinicalTrials.gov lists 49 US studies indexed under Hematologic Malignancy, and 37 of those are currently open to recruitment — roughly 76% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hematologic Malignancy shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 18 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hematologic Malignancy is led by St. Jude Children's Research Hospital with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 49 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hematologic Malignancy?

PlainTrial tracks 49 US clinical trials for Hematologic Malignancy, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hematologic Malignancy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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