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Hematologic Malignancy clinical trials
Every US clinical trial registered for Hematologic Malignancy — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
49 US clinical trials · 37 currently recruiting
The research picture
Hematologic Malignancy has 49 registered US clinical trials, 37 of them open to new participants right now — about 76% of the total.
- 37
- recruiting participants now
- 76%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 6
- top sponsor: St. Jude Children's Research Hospital
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Global Cardio Oncology Registry
The Cleveland Clinic
NCT05598879
Immune Profiling for Cancer Immunotherapy Response
Dartmouth-Hitchcock Medical Center
NCT06116032
BMT-CARE: Psychosocial Intervention for Transplant Caregivers
Massachusetts General Hospital
NCT06472089
HEME Home Transfusion Program
Dana-Farber Cancer Institute
NCT06487247
Mosaic Trial for Stem Cell Transplant Recipients
Northwestern University
NCT06960993
Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Kura Oncology
NCT06001788
Implementation of an Oral Chemotherapy Adherence Intervention
UNC Lineberger Comprehensive Cancer Center
NCT06989489
ONC-MM-2407: The Effect of Virtual Reality Headsets on Pain and Anxiety in the Peri and Post Bone Marrow Biopsy Period
Wake Forest University Health Sciences
NCT07203534
Response to Influenza Vaccination in Pediatric Oncology Patients
St. Jude Children's Research Hospital
NCT05384288
Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy
St. Jude Children's Research Hospital
NCT06579469
Defining the Role of Palliative carE for Patients With Hematologic Malignancies Undergoing Adoptive CEllular Therapy
Massachusetts General Hospital
NCT05646576
Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant
National Cancer Institute (NCI)
NCT06856226
Diet and Cognitive Training in Hematologic Cancer Survivors
University of Alabama at Birmingham
NCT05708716
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
Masonic Cancer Center, University of Minnesota
NCT05735717
Novel 3D Hematological Malignancy Organoid to Study Disease Biology and Chemosensitivity
Wake Forest University Health Sciences
NCT03890614
Intervention for Fatigue in HCT Recipients
Massachusetts General Hospital
NCT05715047
Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy
Washington University School of Medicine
NCT06689800
Mindfulness Intervention for Sleep Disturbance and Symptom Management in Hematologic Cancer Patients During and After Inpatient Treatment
Duke University
NCT06532773
CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma
St. Jude Children's Research Hospital
NCT07257419
Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies
Therapeutic Advances in Childhood Leukemia Consortium
NCT05476770
An Extension Study for Patients Previously Enrolled in Studies With Pelabresib
Novartis Pharmaceuticals
NCT06401356
Mechanisms of Disease R/R in CAR-T for Hematologic Malignancies
Duke University
NCT05397132
αβT Cell/CD19+ B Cell Depletion for Alternative Donor Allogeneic Hematopoietic Cell Transplantation (HSCT)
Nationwide Children's Hospital
NCT06082947
A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant
Memorial Sloan Kettering Cancer Center
NCT07006506
Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)
Tr1X
NCT06462365
A Prospective Study of Conventional Bone Marrow Biopsy Versus Portomar(TM) Biopsy
Aperture Medical Technology
NCT05583734
FDG-PET as an Imaging Modality to Diagnose and Risk Stratify Subclinical, Imaging Negative Ici-Myocarditis
Mayo Clinic
NCT06566209
TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies
St. Jude Children's Research Hospital
NCT07052370
Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution
Children's Hospital Medical Center, Cincinnati
NCT06131801
Phase II Study of Pirtobrutinib With Venetoclax In Relapsed-Refractory MCL (Mantle Cell Lymphoma) Patients
M.D. Anderson Cancer Center
NCT05529069
Home Blood Transfusions
Thomas Jefferson University
NCT07121140
Trial of Novel Anti-leukemia Agents in Flu/Mel RIC Transplant for Myeloid Malignancies
University of Alabama at Birmingham
NCT07044544
Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies
Joshua Sasine, MD, PhD
NCT05887167
Reduced Intensity Fludarabine and TBI Prior to Haplo-Identical Transplantation
Northside Hospital
NCT05417971
CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological Malignancies
St. Jude Children's Research Hospital
NCT06326463
HMCT/CT2401: Abatacept GVHD Prophylaxis Following Omidubicel HCT
Duke University
NCT06731504
Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT06398457
Mobile CARE-App to Promote Coping for Caregivers of Patients Receiving Stem Cell Transplant
Massachusetts General Hospital
NCT05709912
Technology to Assess Vulnerable Older Adults With Cancer and Their Caregivers
City of Hope Medical Center
NCT02041416
Expressive Writing Program Among Young Adults With Blood Cancer
Blood Cancer United
NCT07413991
A Positive Psychology Based Intervention (PATH-C) for Caregivers of HSCT Survivors
Brigham and Women's Hospital
NCT06153797
Patient Fitness and Body Composition During Hematopoietic Stem Cell Transplantation
Garcia, Jose M., MD, PhD
NCT02990130
Study of Benralizumab in People With Skin Side Effects Caused by Cancer Therapies
Memorial Sloan Kettering Cancer Center
NCT04552288
Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients
St. Jude Children's Research Hospital
NCT05164016
Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation
Weill Medical College of Cornell University
NCT04395222
Haploidentical Hematopoietic Cell Transplantation for Children With Hematologic Malignancies and Myelodysplasia
Nationwide Children's Hospital
NCT03431090
Mindfulness and CBT for Sleep
Duke University
NCT04736056
PROACTIVE: Preventing Acute/Chronic GVHD With TocIlizumab Combined With GVHD Prophylaxis Post allogEneic Transplant
Medical College of Wisconsin
NCT03699631
Unrelated Cord Blood Transplant Plus a Haplo-Identical (Half-Matched), T-Cell Depleted Stem Transplant From a Related Donor for Subjects With High Risk Malignancies
Joanne Kurtzberg, MD
NCT00673114
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 12 |
| Phase 2 | 6 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Hematologic Malignancy Trial Landscape
ClinicalTrials.gov lists 49 US studies indexed under Hematologic Malignancy, and 37 of those are currently open to recruitment — roughly 76% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Hematologic Malignancy shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 18 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Hematologic Malignancy is led by St. Jude Children's Research Hospital with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 49 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Hematologic Malignancy?
PlainTrial tracks 49 US clinical trials for Hematologic Malignancy, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Hematologic Malignancy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.