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ClinicalTrials.gov 13 recruiting now official registry

Medulloblastoma clinical trials

13 of 30 indexed Medulloblastoma trials are currently recruiting.

30 US clinical trials · 13 currently recruiting

Medulloblastoma is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is St. Jude Children's Research Hospital, running 6 of these trials.

The research picture

Medulloblastoma has 30 registered US clinical trials, 13 of them open to new participants right now, about 43% of the total.

13
recruiting participants now
43%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
6
top sponsor: St. Jude Children's Research Hospital
Phase 112Phase 211Phase 32Phase 42

Active & Recent Trials

30 total, page 1 of 1

RECRUITING Phase 4 200 participants

68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.

Weill Medical College of Cornell University

NCT04081701

RECRUITING 184 participants

CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation

St. Jude Children's Research Hospital

NCT07085325

RECRUITING Phase 1 146 participants

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

National Cancer Institute (NCI)

NCT06161519

RECRUITING Phase 2 130 participants

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

St. Jude Children's Research Hospital

NCT05535166

RECRUITING Phase 2 118 participants

DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

Giselle Sholler

NCT04696029

RECRUITING NA 74 participants

Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma

University of California, San Francisco

NCT05057702

RECRUITING Phase 1 65 participants

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

Nationwide Children's Hospital

NCT05278208

RECRUITING Phase 1 48 participants

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

St. Jude Children's Research Hospital

NCT05835687

RECRUITING Phase 1 37 participants

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

Theodore S. Johnson

NCT05106296

RECRUITING Phase 2 23 participants

Digoxin Medulloblastoma Study

H. Lee Moffitt Cancer Center and Research Institute

NCT06701812

RECRUITING Phase 1 20 participants

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Valent Technologies

NCT04337177

RECRUITING Phase 1 18 participants

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

Emory University

NCT06624371

RECRUITING Phase 1 18 participants

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

Stanford University

NCT07087002

ACTIVE NOT RECRUITING Phase 2 660 participants

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

St. Jude Children's Research Hospital

NCT01878617

ACTIVE NOT RECRUITING Phase 2 503 participants

Methionine PET/CT Studies In Patients With Cancer

St. Jude Children's Research Hospital

NCT00840047

ACTIVE NOT RECRUITING Phase 3 379 participants

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

Children's Oncology Group

NCT00392327

ACTIVE NOT RECRUITING Phase 4 250 participants

HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

Parth Patel

NCT02875314

ACTIVE NOT RECRUITING Phase 2 130 participants

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

Theodore S. Johnson

NCT04049669

ACTIVE NOT RECRUITING Phase 2 128 participants

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Pfizer

NCT03709680

ACTIVE NOT RECRUITING Phase 2 45 participants

Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

Children's Oncology Group

NCT02724579

ACTIVE NOT RECRUITING Phase 1 35 participants

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Children's Oncology Group

NCT04978727

ACTIVE NOT RECRUITING Phase 1 32 participants

Phase I Study of APX005M in Pediatric Central Nervous System Tumors

Pediatric Brain Tumor Consortium

NCT03389802

ACTIVE NOT RECRUITING Phase 2 22 participants

Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

St. Jude Children's Research Hospital

NCT05128903

ACTIVE NOT RECRUITING Phase 1 10 participants

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

Seattle Children's Hospital

NCT03500991

ACTIVE NOT RECRUITING Phase 1 10 participants

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

City of Hope Medical Center

NCT04661384

COMPLETED Phase 3 549 participants

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma

Children's Oncology Group

NCT00085735

COMPLETED Phase 2 122 participants

Impact of Ga-68 DOTATOC PET-CT Imaging in Management of Neuroendocrine Tumors

Sue O'Dorisio

NCT02441062

COMPLETED NA 90 participants

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

Massachusetts General Hospital

NCT01063114

COMPLETED Phase 2 22 participants

A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB)

Novartis Pharmaceuticals

NCT01708174

COMPLETED Phase 1 18 participants

Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors

Emory University

NCT01331135

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 11
Phase 3 2
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Medulloblastoma Trial Landscape

30 indexed Medulloblastoma studies · 13 recruiting (43%).

Phase mix: 4 late (III/IV) vs 23 early (I/II).

Top sponsor: St. Jude Children's Research Hospital (6 trials), 9 others listed. 30 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Medulloblastoma?

PlainTrial tracks 30 US clinical trials for Medulloblastoma, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Medulloblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.