Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT01946529 · ClinicalTrials.gov registry record · Phase 2

Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors

A Phase 2 study of Desmoplastic Small Round Cell Tumor and Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, sponsored by St. Jude Children's Research Hospital.

Active
Registry status
Phase 2
Development phase
24
Enrollment target
1
Study location

NCT01946529 is a Phase 2 study of Desmoplastic Small Round Cell Tumor and Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor that is active but no longer recruiting, run by St. Jude Children's Research Hospital. The registered enrollment target is 24 participants, below the 71-participant average among 7 other Desmoplastic Small Round Cell Tumor trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT01946529, a Phase 2 study of Desmoplastic Small Round Cell Tumor and Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, is active but no longer recruiting, sponsored by St. Jude Children's Research Hospital.

ACTIVE NOT RECRUITING
Registry status
Phase 2
Development phase
24 participants
Enrollment target
1
Study location

Study Summary

This protocol will study treatment for Ewing sarcoma family of tumors (ESFT) and desmoplastic small round cell tumor (DSRCT). Participants with ESFT will be divided into two treatment groups, A or B, based on tumor characteristics. Group A (standard risk) participants have tumor that is not in the pelvis, has not spread to other parts of the body, and are less than 14 years of age. Because previous clinical trials have shown that standard treatment is very effective for children whose tumors have these characteristics, these participants will receive standard treatment. Group B (high risk) participants are 14 years of age or older or have tumor in the pelvis, or the tumor has spread to other parts of the body. Participants with DSRCT in the abdomen and/or pelvis or with tumor that cannot be removed by surgery alone or has spread to other parts of the body will be included in Group B. Participants in this group are considered high risk because there is a greater chance of tumor recurring following standard treatments currently in use. All participants will be followed and evaluated for 10 years following completion of therapy.

Conditions Studied

Desmoplastic Small Round Cell Tumor Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Ewing Sarcoma of Bone or Soft Tissue

Interventions

  • DRUG cyclophosphamide
  • DRUG doxorubicin
  • DRUG etoposide
  • DRUG ifosfamide
  • DRUG vincristine

Study Locations (1)

Tennessee

  • St. Jude Children's Research Hospital - Memphis

Trial Details

FieldValue
Enrollment Target 24 participants
Start Date 2013-12-27
Est. Completion 2026-07
Phase Phase 2

Sponsor

St. Jude Children's Research Hospital

410 total trials

Interested in This Trial?

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01946529

The ClinicalTrials.gov registry entry for NCT01946529 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 71-participant average among 7 other Desmoplastic Small Round Cell Tumor trials with a reported enrollment target (66% lower). The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.

The record links to 4 conditions, with Desmoplastic Small Round Cell Tumor appearing as the primary indexed condition, and to 5 interventions - of which cyclophosphamide is the first listed.

NCT01946529 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.

Frequently Asked Questions

What is clinical trial NCT01946529 about?

NCT01946529 is a clinical study titled "Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors". This protocol will study treatment for Ewing sarcoma family of tumors (ESFT) and desmoplastic small round cell tumor (DSRCT). Participants with ESFT will be divided into two treatment groups, A or B, based on tumor characteristics. Group A (standard risk) participants have tumor that is not in the ...

What is the current status of trial NCT01946529?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 24 participants. The study started on 2013-12-27. Estimated completion is 2026-07.

What conditions does trial NCT01946529 study?

This clinical trial studies the following conditions: Desmoplastic Small Round Cell Tumor, Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Ewing Sarcoma of Bone or Soft Tissue.

What interventions are being tested in trial NCT01946529?

The interventions under investigation include: cyclophosphamide (DRUG), doxorubicin (DRUG), etoposide (DRUG), ifosfamide (DRUG), vincristine (DRUG).

Who is sponsoring clinical trial NCT01946529?

This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT01946529 being conducted?

This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Desmoplastic Small Round Cell Tumor

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Explore more on PlainTrial

Desmoplastic Small Round Cell Tumor

All registered trials for this condition

Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

All registered trials for this condition

Tennessee

All trials with a study site in Tennessee

Recruiting now

Find trials open to new participants near you

Rankings

Top sponsors, conditions, and phases

Read our methodology - how this data is sourced, computed, and verified.

Related

Browse all → | Rankings →
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.